Metabolic competition in the tumor microenvironment is a driver of cancer progression CH Chang, J Qiu, D O’Sullivan, MD Buck, T Noguchi, JD Curtis, Q Chen, ... Cell 162 (6), 1229-1241, 2015 | 2924 | 2015 |
Posttranscriptional control of T cell effector function by aerobic glycolysis CH Chang, JD Curtis, LB Maggi, B Faubert, AV Villarino, D O’Sullivan, ... Cell 153 (6), 1239-1251, 2013 | 2298 | 2013 |
Mitochondrial dynamics controls T cell fate through metabolic programming MD Buck, D O’Sullivan, RIK Geltink, JD Curtis, CH Chang, DE Sanin, ... Cell 166 (1), 63-76, 2016 | 1353 | 2016 |
T cell metabolism drives immunity MD Buck, D O’sullivan, EL Pearce Journal of Experimental Medicine 212 (9), 1345-1360, 2015 | 1229 | 2015 |
Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages SCC Huang, B Everts, Y Ivanova, D O'sullivan, M Nascimento, AM Smith, ... Nature immunology 15 (9), 846-855, 2014 | 1160 | 2014 |
Memory CD8+ T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development D O’Sullivan, GJW van der Windt, SCC Huang, JD Curtis, CH Chang, ... Immunity 41 (1), 75-88, 2014 | 843 | 2014 |
CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability GJW Van Der Windt, D O’Sullivan, B Everts, SCC Huang, MD Buck, ... Proceedings of the National Academy of Sciences 110 (35), 14336-14341, 2013 | 580 | 2013 |
Polyamines and eIF5A hypusination modulate mitochondrial respiration and macrophage activation DJ Puleston, MD Buck, RIK Geltink, RL Kyle, G Caputa, D O’Sullivan, ... Cell metabolism 30 (2), 352-363. e8, 2019 | 307 | 2019 |
Mitochondrial priming by CD28 RIK Geltink, D O’Sullivan, M Corrado, A Bremser, MD Buck, JM Buescher, ... Cell 171 (2), 385-397. e11, 2017 | 301 | 2017 |
Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells NR Mathew, F Baumgartner, L Braun, D O'Sullivan, S Thomas, ... Nature medicine 24 (3), 282-291, 2018 | 288 | 2018 |
Acetate promotes T cell effector function during glucose restriction J Qiu, M Villa, DE Sanin, MD Buck, D O’Sullivan, R Ching, M Matsushita, ... Cell reports 27 (7), 2063-2074. e5, 2019 | 286 | 2019 |
Targeting T cell metabolism for therapy D O'Sullivan, EL Pearce Trends in immunology 36 (2), 71-80, 2015 | 285 | 2015 |
Metabolic interventions in the immune response to cancer D O’Sullivan, DE Sanin, EJ Pearce, EL Pearce Nature Reviews Immunology 19 (5), 324-335, 2019 | 262 | 2019 |
Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms A Prestipino, AJ Emhardt, K Aumann, D O’Sullivan, SP Gorantla, ... Science translational medicine 10 (429), eaam7729, 2018 | 232 | 2018 |
Metabolic conditioning of CD8+ effector T cells for adoptive cell therapy RI Klein Geltink, J Edwards-Hicks, P Apostolova, D O’Sullivan, DE Sanin, ... Nature metabolism 2 (8), 703-716, 2020 | 119 | 2020 |
Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans FM Uhl, S Chen, D O’Sullivan, J Edwards-Hicks, G Richter, E Haring, ... Science translational medicine 12 (567), eabb8969, 2020 | 110 | 2020 |
Mitochondrial membrane potential regulates nuclear gene expression in macrophages exposed to prostaglandin E2 DE Sanin, M Matsushita, RIK Geltink, KM Grzes, N van Teijlingen Bakker, ... Immunity 49 (6), 1021-1033. e6, 2018 | 105 | 2018 |
The metabolic spectrum of memory T cells D O'Sullivan Immunology and Cell Biology 97 (7), 636-646, 2019 | 72 | 2019 |
Treatment with the antipsychotic agent, risperidone, reduces disease severity in experimental autoimmune encephalomyelitis D O'Sullivan, L Green, S Stone, P Zareie, M Kharkrang, D Fong, B Connor, ... PloS one 9 (8), e104430, 2014 | 67 | 2014 |
An LKB1–mitochondria axis controls TH17 effector function F Baixauli, K Piletic, DJ Puleston, M Villa, CS Field, LJ Flachsmann, ... Nature 610 (7932), 555-561, 2022 | 56 | 2022 |