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David O'Sullivan
David O'Sullivan
Malaghan Institute of Medical Research
Dirección de correo verificada de malaghan.org.nz
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Metabolic competition in the tumor microenvironment is a driver of cancer progression
CH Chang, J Qiu, D O’Sullivan, MD Buck, T Noguchi, JD Curtis, Q Chen, ...
Cell 162 (6), 1229-1241, 2015
29242015
Posttranscriptional control of T cell effector function by aerobic glycolysis
CH Chang, JD Curtis, LB Maggi, B Faubert, AV Villarino, D O’Sullivan, ...
Cell 153 (6), 1239-1251, 2013
22982013
Mitochondrial dynamics controls T cell fate through metabolic programming
MD Buck, D O’Sullivan, RIK Geltink, JD Curtis, CH Chang, DE Sanin, ...
Cell 166 (1), 63-76, 2016
13532016
T cell metabolism drives immunity
MD Buck, D O’sullivan, EL Pearce
Journal of Experimental Medicine 212 (9), 1345-1360, 2015
12292015
Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages
SCC Huang, B Everts, Y Ivanova, D O'sullivan, M Nascimento, AM Smith, ...
Nature immunology 15 (9), 846-855, 2014
11602014
Memory CD8+ T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development
D O’Sullivan, GJW van der Windt, SCC Huang, JD Curtis, CH Chang, ...
Immunity 41 (1), 75-88, 2014
8432014
CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability
GJW Van Der Windt, D O’Sullivan, B Everts, SCC Huang, MD Buck, ...
Proceedings of the National Academy of Sciences 110 (35), 14336-14341, 2013
5802013
Polyamines and eIF5A hypusination modulate mitochondrial respiration and macrophage activation
DJ Puleston, MD Buck, RIK Geltink, RL Kyle, G Caputa, D O’Sullivan, ...
Cell metabolism 30 (2), 352-363. e8, 2019
3072019
Mitochondrial priming by CD28
RIK Geltink, D O’Sullivan, M Corrado, A Bremser, MD Buck, JM Buescher, ...
Cell 171 (2), 385-397. e11, 2017
3012017
Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells
NR Mathew, F Baumgartner, L Braun, D O'Sullivan, S Thomas, ...
Nature medicine 24 (3), 282-291, 2018
2882018
Acetate promotes T cell effector function during glucose restriction
J Qiu, M Villa, DE Sanin, MD Buck, D O’Sullivan, R Ching, M Matsushita, ...
Cell reports 27 (7), 2063-2074. e5, 2019
2862019
Targeting T cell metabolism for therapy
D O'Sullivan, EL Pearce
Trends in immunology 36 (2), 71-80, 2015
2852015
Metabolic interventions in the immune response to cancer
D O’Sullivan, DE Sanin, EJ Pearce, EL Pearce
Nature Reviews Immunology 19 (5), 324-335, 2019
2622019
Oncogenic JAK2V617F causes PD-L1 expression, mediating immune escape in myeloproliferative neoplasms
A Prestipino, AJ Emhardt, K Aumann, D O’Sullivan, SP Gorantla, ...
Science translational medicine 10 (429), eaam7729, 2018
2322018
Metabolic conditioning of CD8+ effector T cells for adoptive cell therapy
RI Klein Geltink, J Edwards-Hicks, P Apostolova, D O’Sullivan, DE Sanin, ...
Nature metabolism 2 (8), 703-716, 2020
1192020
Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans
FM Uhl, S Chen, D O’Sullivan, J Edwards-Hicks, G Richter, E Haring, ...
Science translational medicine 12 (567), eabb8969, 2020
1102020
Mitochondrial membrane potential regulates nuclear gene expression in macrophages exposed to prostaglandin E2
DE Sanin, M Matsushita, RIK Geltink, KM Grzes, N van Teijlingen Bakker, ...
Immunity 49 (6), 1021-1033. e6, 2018
1052018
The metabolic spectrum of memory T cells
D O'Sullivan
Immunology and Cell Biology 97 (7), 636-646, 2019
722019
Treatment with the antipsychotic agent, risperidone, reduces disease severity in experimental autoimmune encephalomyelitis
D O'Sullivan, L Green, S Stone, P Zareie, M Kharkrang, D Fong, B Connor, ...
PloS one 9 (8), e104430, 2014
672014
An LKB1–mitochondria axis controls TH17 effector function
F Baixauli, K Piletic, DJ Puleston, M Villa, CS Field, LJ Flachsmann, ...
Nature 610 (7932), 555-561, 2022
562022
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