Learned protein embeddings for machine learning KK Yang, Z Wu, CN Bedbrook, FH Arnold Bioinformatics 34 (15), 2642-2648, 2018 | 365 | 2018 |
The jellyfish Cassiopea exhibits a sleep-like state RD Nath, CN Bedbrook, MJ Abrams, T Basinger, JS Bois, DA Prober, ... Current Biology 27 (19), 2984-2990. e3, 2017 | 283 | 2017 |
Machine learning-guided channelrhodopsin engineering enables minimally invasive optogenetics CN Bedbrook, KK Yang, JE Robinson, ED Mackey, V Gradinaru, ... Nature methods 16 (11), 1176-1184, 2019 | 223 | 2019 |
Viral strategies for targeting the central and peripheral nervous systems CN Bedbrook, BE Deverman, V Gradinaru Annual review of neuroscience 41 (1), 323-348, 2018 | 180 | 2018 |
Archaerhodopsin variants with enhanced voltage-sensitive fluorescence in mammalian and Caenorhabditis elegans neurons NC Flytzanis, CN Bedbrook, H Chiu, MKM Engqvist, C Xiao, KY Chan, ... Nature communications 5 (1), 4894, 2014 | 168 | 2014 |
Machine learning to design integral membrane channelrhodopsins for efficient eukaryotic expression and plasma membrane localization CN Bedbrook, KK Yang, AJ Rice, V Gradinaru, FH Arnold PLoS computational biology 13 (10), e1005786, 2017 | 134 | 2017 |
Directed evolution of a bright near-infrared fluorescent rhodopsin using a synthetic chromophore L Herwig, AJ Rice, CN Bedbrook, RK Zhang, A Lignell, JKB Cahn, ... Cell chemical biology 24 (3), 415-425, 2017 | 70 | 2017 |
Genetically encoded spy peptide fusion system to detect plasma membrane-localized proteins in vivo CN Bedbrook, M Kato, SR Kumar, A Lakshmanan, RD Nath, F Sun, ... Chemistry & biology 22 (8), 1108-1121, 2015 | 69 | 2015 |
Recent advances in engineering microbial rhodopsins for optogenetics RS McIsaac, CN Bedbrook, FH Arnold Current opinion in structural biology 33, 8-15, 2015 | 62 | 2015 |
Structure-guided SCHEMA recombination generates diverse chimeric channelrhodopsins CN Bedbrook, AJ Rice, KK Yang, X Ding, S Chen, EM LeProust, ... Proceedings of the National Academy of Sciences 114 (13), E2624-E2633, 2017 | 60 | 2017 |
An automated feeding system for the African killifish reveals the impact of diet on lifespan and allows scalable assessment of associative learning A McKay, EK Costa, J Chen, CK Hu, X Chen, CN Bedbrook, RC Khondker, ... Elife 11, e69008, 2022 | 24 | 2022 |
Hypocrea jecorina Cellobiohydrolase I Stabilizing Mutations Identified Using Noncontiguous Recombination MA Smith, CN Bedbrook, T Wu, FH Arnold ACS synthetic biology 2 (12), 690-696, 2013 | 24 | 2013 |
Rapid and precise genome engineering in a naturally short-lived vertebrate CN Bedbrook, RD Nath, R Nagvekar, K Deisseroth, A Brunet Elife 12, e80639, 2023 | 11 | 2023 |
Husbandry of the African turquoise killifish Nothobranchius furzeri RD Nath, CN Bedbrook, R Nagvekar, A Brunet Cold Spring Harbor Protocols 2023 (6), pdb. prot107738, 2023 | 6 | 2023 |
Rapid and precise genome engineering in a naturally short-lived vertebrate RD Nath, CN Bedbrook, R Nagvekar, K Deisseroth, A Brunet bioRxiv, 2022.05. 25.493454, 2022 | 5 | 2022 |
Engineered light-sensitive proteins V Gradinaru, CN Bedbrook, FH Arnold, KK Yang US Patent 11,858,969, 2024 | 2 | 2024 |
Life span assessment in the African turquoise killifish Nothobranchius furzeri CN Bedbrook, RD Nath, R Barajas, A Brunet Cold Spring Harbor Protocols 2023 (6), pdb. prot107917, 2023 | 1 | 2023 |
Neuronal activity sensing and modulation with Archers N Flytzanis, C Bedbrook, V Gradinaru SPIE Newsroom, 2014 | 1 | 2014 |
Engineered light-sensitive proteins V Gradinaru, CN Bedbrook, FH Arnold, KK Yang US Patent App. 18/517,703, 2024 | | 2024 |
Engineering Novel Rhodopsins for Neuroscience CN Bedbrook California Institute of Technology, 2018 | | 2018 |