| Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein J Lei, Y Kusov, R Hilgenfeld Antiviral research 149, 58-74, 2018 | 812 | 2018 |
| SARS-CoV-2 Mpro inhibitors with antiviral activity in a transgenic mouse model J Qiao, YS Li, R Zeng, FL Liu, RH Luo, C Huang, YF Wang, J Zhang, ... Science 371 (6536), 1374-1378, 2021 | 403 | 2021 |
| Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor J Lei, G Hansen, C Nitsche, CD Klein, L Zhang, R Hilgenfeld Science 353 (6298), 503-505, 2016 | 388 | 2016 |
| p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PLpro via E3 ubiquitin ligase RCHY1 Y Ma-Lauer, J Carbajo-Lozoya, MY Hein, MA Müller, W Deng, J Lei, ... Proceedings of the National Academy of Sciences 113 (35), E5192-E5201, 2016 | 237 | 2016 |
| Structural characterization of the C-terminal domain of SARS-CoV-2 nucleocapsid protein R Zhou, R Zeng, A von Brunn, J Lei Molecular biomedicine 1, 1-11, 2020 | 95 | 2020 |
| Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features J Lei, JR Mesters, C Drosten, S Anemüller, Q Ma, R Hilgenfeld Antiviral research 109, 72-82, 2014 | 91 | 2014 |
| An orally available Mpro inhibitor is effective against wild-type SARS-CoV-2 and variants including Omicron BX Quan, H Shuai, AJ Xia, Y Hou, R Zeng, XL Liu, GF Lin, JX Qiao, WP Li, ... Nature Microbiology 7 (5), 716-725, 2022 | 83 | 2022 |
| RNA‐virus proteases counteracting host innate immunity J Lei, R Hilgenfeld FEBS letters 591 (20), 3190-3210, 2017 | 80 | 2017 |
| A new generation Mpro inhibitor with potent activity against SARS-CoV-2 Omicron variants C Huang, H Shuai, J Qiao, Y Hou, R Zeng, A Xia, L Xie, Z Fang, Y Li, ... Signal Transduction and Targeted Therapy 8 (1), 128, 2023 | 50 | 2023 |
| Virus–host interactomes—antiviral drug discovery Y Ma-Lauer, J Lei, R Hilgenfeld, A Von Brunn Current opinion in virology 2 (5), 614-621, 2012 | 48 | 2012 |
| The Structure of the Zika Virus Protease, NS2B/NS3pro R Hilgenfeld, J Lei, L Zhang Dengue and Zika: Control and Antiviral Treatment Strategies, 131-145, 2018 | 39 | 2018 |
| Computational simulations reveal the binding dynamics between human ACE2 and the receptor binding domain of SARS‐CoV‐2 spike protein CS Lupala, X Li, J Lei, H Chen, J Qi, H Liu, XD Su Quantitative Biology 9 (1), 61-72, 2021 | 38 | 2021 |
| The SARS‐unique domain (SUD) of SARS‐CoV and SARS‐CoV‐2 interacts with human Paip1 to enhance viral RNA translation J Lei, Y Ma‐Lauer, Y Han, M Thoms, R Buschauer, J Jores, V Thiel, ... The EMBO journal 40 (11), e102277, 2021 | 35 | 2021 |
| Structural and mutational analysis of the interaction between the Middle-East respiratory syndrome coronavirus (MERS-CoV) papain-like protease and human ubiquitin J Lei, R Hilgenfeld Virologica Sinica 31, 288-299, 2016 | 32 | 2016 |
| Structural and biochemical analyses of YvgN and YtbE from Bacillus subtilis J Lei, YF Zhou, LF Li, XD Su Protein Science 18 (8), 1792-1800, 2009 | 27 | 2009 |
| SARS-CoV-2 impairs the disassembly of stress granules and promotes ALS-associated amyloid aggregation Y Li, S Lu, J Gu, W Xia, S Zhang, S Zhang, Y Wang, C Zhang, Y Sun, J Lei, ... Protein & Cell 13 (8), 602-614, 2022 | 22 | 2022 |
| Lybatides from Lycium barbarum Contain An Unusual Cystine-stapled Helical Peptide Scaffold WL Tan, KH Wong, J Lei, N Sakai, HW Tan, R Hilgenfeld, JP Tam Scientific reports 7 (1), 5194, 2017 | 15 | 2017 |
| Structural insights into ribonucleoprotein dissociation by nucleocapsid protein interacting with non-structural protein 3 in SARS-CoV-2 X Ni, Y Han, R Zhou, Y Zhou, J Lei Communications Biology 6 (1), 193, 2023 | 13 | 2023 |
| Crystal structures of phosphotransferase system enzymes PtxB (IIBAsc) and PtxA (IIAAsc) from Streptococcus mutans J Lei, LF Li, XD Su Journal of molecular biology 386 (2), 465-475, 2009 | 12 | 2009 |
| Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition V Kotov, M Killer, KEJ Jungnickel, J Lei, G Finocchio, J Steinke, K Bartels, ... Cell Reports 42 (8), 2023 | 10 | 2023 |
