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Sagie Brodsky
Sagie Brodsky
Systems biologist @ Protai
Dirección de correo verificada de protai.bio - Página principal
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Intrinsically disordered regions direct transcription factor in vivo binding specificity
S Brodsky*, T Jana*, K Mittelman, M Chapal, DK Kumar, M Carmi, ...
Molecular cell 79 (3), 459-471. e4, 2020
2872020
Order through disorder: The role of intrinsically disordered regions in transcription factor binding specificity
S Brodsky*, T Jana*, N Barkai
Current opinion in structural biology 71, 110-115, 2021
642021
Speed–specificity trade-offs in the transcription factors search for their genomic binding sites
T Jana*, S Brodsky*, N Barkai
Trends in Genetics, 2021
562021
Resolving noise–control conflict by gene duplication
M Chapal, S Mintzer, S Brodsky, M Carmi, N Barkai
PLoS biology 17 (11), e3000289, 2019
532019
Ubiquitin-independent proteasomal degradation driven by C-degron pathways
Y Makaros, A Raiff, RT Timms, AR Wagh, MI Gueta, A Bekturova, ...
Molecular Cell 83 (11), 1921-1935. e7, 2023
402023
Complementary strategies for directing in vivo transcription factor binding through DNA binding domains and intrinsically disordered regions
DK Kumar, F Jonas, T Jana, S Brodsky, M Carmi, N Barkai
Molecular cell 83 (9), 1462-1473. e5, 2023
372023
Transcription factor binding to replicated DNA
R Bar-Ziv*, S Brodsky*, M Chapal, N Barkai
Cell reports 30 (12), 3989-3995. e4, 2020
242020
The molecular grammar of protein disorder guiding genome-binding locations
F Jonas, M Carmi, B Krupkin, J Steinberger, S Brodsky, T Jana, N Barkai
Nucleic acids research 51 (10), 4831-4844, 2023
212023
Intrinsically disordered regions of the Msn2 transcription factor encode multiple functions using interwoven sequence grammars
V Mindel*, S Brodsky*, A Cohen, W Manadre, F Jonas, M Carmi, N Barkai
Nucleic Acids Research, gkad1191, 2023
122023
Phosphorylation of Serine 114 of the transcription factor ABSCISIC ACID INSENSITIVE 4 is essential for activity
N Eisner, T Maymon, EC Sanchez, D Bar-Zvi, S Brodsky, R Finkelstein, ...
Plant Science 305, 110847, 2021
102021
Pls1 is a peroxisomal matrix protein with a role in regulating lysine biosynthesis
Y David, IG Castro, E Yifrach, C Bibi, E Katawi, D Yahav Har-Shai, ...
Cells 11 (9), 1426, 2022
92022
Revisiting the model for coactivator recruitment: Med15 can select its target sites independent of promoter-bound transcription factors
V Mindel*, S Brodsky*, H Yung, W Manadre, N Barkai
Nucleic Acids Research, gkae718, 2024
52024
Massively Parallel Binding Assay (MPBA) reveals limited transcription factor binding cooperativity, challenging models of specificity
T Jana Lang*, S Brodsky*, W Manadre, M Vidavski, G Valinsky, V Mindel, ...
Nucleic Acids Research, gkae846, 2024
22024
Beyond RNA-binding domains: determinants of protein–RNA binding
I Zigdon, M Carmi, S Brodsky, Z Rosenwaser, N Barkai, F Jonas
RNA 30 (12), 1620-1633, 2024
2024
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