Lanosterol reverses protein aggregation in cataracts L Zhao, XJ Chen, J Zhu, YB Xi, X Yang, LD Hu, H Ouyang, SH Patel, X Jin, ... Nature 523 (7562), 607-611, 2015 | 501 | 2015 |
Molecular genetics of congenital cataracts J Li, X Chen, Y Yan, K Yao Experimental Eye Research 191, 107872, 2020 | 96 | 2020 |
Cataract: advances in surgery and whether surgery remains the only treatment in future X Chen, J Xu, X Chen, K Yao Advances in Ophthalmology Practice and Research 1 (1), 100008, 2021 | 80 | 2021 |
Knockdown of creatine kinase B inhibits ovarian cancer progression by decreasing glycolysis XH Li, XJ Chen, WB Ou, Q Zhang, ZR Lv, Y Zhan, L Ma, T Huang, YB Yan, ... The international journal of biochemistry & cell biology 45 (5), 979-986, 2013 | 71 | 2013 |
Advances in pharmacotherapy of cataracts J Xu, Q Fu, X Chen, K Yao Annals of translational medicine 8 (22), 1552, 2020 | 46 | 2020 |
Lanosterol and 25-hydroxycholesterol dissociate crystallin aggregates isolated from cataractous human lens via different mechanisms XJ Chen, LD Hu, K Yao, YB Yan Biochemical and biophysical research communications 506 (4), 868-873, 2018 | 43 | 2018 |
RNAe: an effective method for targeted protein translation enhancement by artificial non-coding RNA with SINEB2 repeat Y Yao, S Jin, H Long, Y Yu, Z Zhang, G Cheng, C Xu, Y Ding, Q Guan, ... Nucleic acids research 43 (9), e58-e58, 2015 | 41 | 2015 |
ATP can efficiently stabilize protein through a unique mechanism X Ou, Y Lao, J Xu, Y Wutthinitikornkit, R Shi, X Chen, J Li JACS Au 1 (10), 1766-1777, 2021 | 40 | 2021 |
Multiple cytokine analyses of aqueous humor from the patients with retinitis pigmentosa B Lu, H Yin, Q Tang, W Wang, C Luo, X Chen, X Zhang, K Lai, J Xu, ... Cytokine 127, 154943, 2020 | 40 | 2020 |
Effects of cataract-causing mutations W59C and W151C on βB2-crystallin structure, stability and folding WJ Zhao, J Xu, XJ Chen, HH Liu, K Yao, YB Yan International Journal of Biological Macromolecules 103, 764-770, 2017 | 34 | 2017 |
Congenital cataract-causing mutation G129C in γC-crystallin promotes the accumulation of two distinct unfolding intermediates that form highly toxic aggregates YB Xi, XJ Chen, WJ Zhao, YB Yan Journal of Molecular Biology 427 (17), 2765-2781, 2015 | 29 | 2015 |
A new dawn for cataracts RA Quinlan Science 350 (6261), 636-637, 2015 | 28 | 2015 |
DsHsp90 is involved in the early response of Dunaliella salina to environmental stress SJ Wang, MJ Wu, XJ Chen, Y Jiang, YB Yan International journal of molecular sciences 13 (7), 7963-7979, 2012 | 28 | 2012 |
Synthesis, evaluation, and structure–activity relationship study of lanosterol derivatives to reverse mutant-crystallin-induced protein aggregation X Yang, XJ Chen, Z Yang, YB Xi, L Wang, Y Wu, YB Yan, Y Rao Journal of Medicinal Chemistry 61 (19), 8693-8706, 2018 | 26 | 2018 |
The cataract-related S39C variant increases γS-crystallin sensitivity to environmental stress by destroying the intermolecular disulfide cross-links X Yang, J Xu, C Fu, Z Jia, K Yao, X Chen Biochemical and Biophysical Research Communications 526 (2), 459-465, 2020 | 24 | 2020 |
Lanosterol modulates proteostasis via dissolving cytosolic sequestosomes/aggresome-like induced structures LD Hu, J Wang, XJ Chen, YB Yan Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1867 (2), 118617, 2020 | 24 | 2020 |
βB2 W151R mutant is prone to degradation, aggregation and exposes the hydrophobic side chains in the fourth Greek Key motif J Xu, H Wang, A Wang, J Xu, C Fu, Z Jia, K Yao, X Chen Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1867 (2), 166018, 2021 | 20 | 2021 |
Membrane insertion of αA-crystallin is oligomer-size dependent HC Tjondro, YB Xi, XJ Chen, JT Su, YB Yan Biochemical and Biophysical Research Communications 473 (1), 1-7, 2016 | 20 | 2016 |
Cholesterol metabolism: physiological regulation and diseases J Guo, S Chen, Y Zhang, J Liu, L Jiang, L Hu, K Yao, Y Yu, X Chen MedComm 5 (2), e476, 2024 | 19 | 2024 |
Circulating lipoprotein (a) levels and health outcomes: Phenome-wide Mendelian randomization and disease-trajectory analyses SC Larsson, L Wang, X Li, F Jiang, X Chen, CS Mantzoros Metabolism 137, 155347, 2022 | 18 | 2022 |