Simon Cook

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kathryn balmannoBabraham InstituteDirección de correo verificada de babraham.ac.uk
Matthew SaleUCSFDirección de correo verificada de ucsf.edu
Michael WakelamBabraham InstituteDirección de correo verificada de babraham.ac.uk
Pamela LochheadBabraham InstituteDirección de correo verificada de babraham.ac.uk
Martin McMahonCumming-Presidential Professor of Cancer Biology, Huntsman Cancer Institute, Univ. of UtahDirección de correo verificada de hci.utah.edu
Jim CauntLecturer, University of BathDirección de correo verificada de bath.ac.uk
Wolf ReikHead, Epigenetics Programme, Babraham Institute Cambridge, UKDirección de correo verificada de babraham.ac.uk
Miguel R BrancoBlizard Institute, QMUL, London, UKDirección de correo verificada de qmul.ac.uk
Llewelyn RoderickKULeuvenDirección de correo verificada de kuleuven.be
Myriam HembergerUniversity of Calgary, CanadaDirección de correo verificada de ucalgary.ca
Mona Bajaj-ElliottUniversity College LondonDirección de correo verificada de ucl.ac.uk
Sylvie GuichardExecutive Director Translational Medicine Novo NordiskDirección de correo verificada de astrazeneca.com
Julie WickendenPost-doctoral Researcher, University of CambridgeDirección de correo verificada de horizondiscovery.com
Scott NewmanGeneDxDirección de correo verificada de sema4.com
Gabriel NuñezPaul de Kruif Professor of Pathology, University of Michigan Medical SchoolDirección de correo verificada de umich.edu
Heather J LeeThe University of NewcastleDirección de correo verificada de newcastle.edu.au
Julia ArandPostdoctoral fellow, Medical University ViennaDirección de correo verificada de meduniwien.ac.at
Timothy A HoreGroup Leader, Department of Anatomy, University of OtagoDirección de correo verificada de otago.ac.nz
Ruth DenshamUniversity of BirminghamDirección de correo verificada de bham.ac.uk
Martin BootmancambridgeDirección de correo verificada de open.ac.uk

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Simon Cook

Signalling Programme, The Babraham Institute

Dirección de correo verificada de babraham.ac.uk - Página principal

Signal transduction protein kinases cell proliferation cell death cell senescence


Título Ordenar por citas Ordenar por año Ordenar por título	Citado por Citado por	Año
Inhibition by cAMP of Ras-dependent activation of Raf SJ Cook, F McCormick Science 262 (5136), 1069-1072, 1993	1203	1993
Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival HL Roderick, SJ Cook Nature Reviews Cancer 8 (5), 361-375, 2008	862	2008
Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim R Ley, K Balmanno, K Hadfield, C Weston, SJ Cook Journal of Biological Chemistry 278 (21), 18811-18816, 2003	794	2003
MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road CJ Caunt, MJ Sale, PD Smith, SJ Cook Nature Reviews Cancer 15, 577–592, 2015	648	2015
Characterization of two alternately spliced forms of phospholipase D1: activation of the purified enzymes by phosphatidylinositol 4, 5-bisphosphate, ADP-ribosylation factor … SM Hammond, JM Jenco, S Nakashima, K Cadwallader, Q Gu, S Cook, ... Journal of Biological Chemistry 272 (6), 3860-3868, 1997	612	1997
Tumour cell survival signalling by the ERK1/2 pathway K Balmanno, SJ Cook Cell Death & Differentiation 16 (3), 368-377, 2009	610	2009
Rap1V12 antagonises Ras-dependent activation of ERK1 & ERK2 by LPA and EGF in Rat-1 fibroblasts S Cook, B Rubinfeld, F Albert, I & McCormick EMBO Journal 12, 3475-3485, 1993	457	1993
FGF signaling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency G Ficz, TA Hore, F Santos, HJ Lee, W Dean, J Arand, F Krueger, D Oxley, ... Cell stem cell 13 (3), 351-359, 2013	451	2013
The role of MAPK signalling pathways in the response to endoplasmic reticulum stress NJ Darling, SJ Cook Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1843 (10), 2150-2163, 2014	440	2014
Regulatory phosphorylation of Bim: sorting out the ERK from the JNK. R Ley, KE Ewings, K Hadfield, SJ Cook Cell Death & Differentiation 12 (8), 2005	400	2005
Paclitaxel-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt A Sunters, PA Madureira, KM Pomeranz, M Aubert, JJ Brosens, SJ Cook, ... Cancer research 66 (1), 212-220, 2006	308	2006
Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells K Balmanno, SJ Cook Oncogene 18 (20), 3085-3097, 1999	307	1999
The Repertoire of Fos and Jun Proteins Expressed during the G₁ Phase of the Cell Cycle Is Determined by the Duration of Mitogen-Activated Protein Kinase … SJ Cook, N Aziz, M McMahon Molecular and Cellular Biology 19 (1), 330-341, 1999	256	1999
Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells AS Little, K Balmanno, MJ Sale, S Newman, JR Dry, M Hampson, ... Science signaling 4 (166), ra17-ra17, 2011	250	2011
Extracellular signal-regulated kinases 1/2 are serum-stimulated “BimEL kinases” that bind to the BH3-only protein BimEL causing its phosphorylation and turnover R Ley, KE Ewings, K Hadfield, E Howes, K Balmanno, SJ Cook Journal of Biological Chemistry 279 (10), 8837-8847, 2004	250	2004
De-regulated FGF receptors as therapeutic targets in cancer V Knights, SJ Cook Pharmacology & therapeutics 125 (1), 105-117, 2010	242	2010
Nucleotide-binding oligomerization domain-1 and epidermal growth factor receptor: critical regulators of β-defensins during Helicobacter pylori infection PK Boughan, RH Argent, M Body-Malapel, JH Park, KE Ewings, ... Journal of Biological Chemistry 281 (17), 11637-11648, 2006	239	2006
Activation of ERK1/2 by ΔRaf-1: ER* represses Bim expression independently of the JNK or PI3K pathways CR Weston, K Balmanno, C Chalmers, K Hadfield, SA Molton, R Ley, ... Oncogene 22 (9), 1281-1293, 2003	232	2003
Analysis of the water-soluble products of phosphatidylcholine breakdown by ion-exchange chromatography. Bombesin and TPA (12-O-tetradecanoylphorbol 13 … SJ Cook, MJO Wakelam Biochemical Journal 263 (2), 581-587, 1989	232	1989
The selective protein kinase C inhibitor, Ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression, and activates Jun N … J Beltman, F McCormick, SJ Cook Journal of Biological Chemistry 271 (43), 27018-27024, 1996	231	1996

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