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Subu Subramanian
Subu Subramanian
Postdoc, Vanderbilt University
Dirección de correo verificada de berkeley.edu
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Large language models generate functional protein sequences across diverse families
A Madani, B Krause, ER Greene, S Subramanian, BP Mohr, JM Holton, ...
Nature Biotechnology 41 (8), 1099-1106, 2023
7562023
Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein
K Yang, C Wang, AJB Kreutzberger, R Ojha, S Kuivanen, S Couoh-Cardel, ...
Proceedings of the National Academy of Sciences 119 (40), e2210990119, 2022
332022
Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction
S Subramanian, K Gorday, K Marcus, MR Orellana, P Ren, XR Luo, ...
Elife 10, e66181, 2021
192021
Deep learning-enabled design of synthetic orthologs of a signaling protein
X Lian, N Praljak, SK Subramanian, S Wasinger, R Ranganathan, ...
bioRxiv, 2022.12. 21.521443, 2022
102022
A protocol for functional assessment of whole-protein saturation mutagenesis libraries utilizing high-throughput sequencing
MA Stiffler, SK Subramanian, VH Salinas, R Ranganathan
Journal of Visualized Experiments: Jove, 54119, 2016
82016
A set of experimentally validated, mutually orthogonal primers for combinatorially specifying genetic components
SK Subramanian, WP Russ, R Ranganathan
Synthetic Biology 3 (1), ysx008, 2018
62018
Deep-learning-based design of synthetic orthologs of SH3 signaling domains
X Lian, N Praljak, SK Subramanian, S Wasinger, R Ranganathan, ...
Cell Systems 15 (8), 725-737. e7, 2024
32024
Autoinhibition of a clamp-loader ATPase revealed by deep mutagenesis and cryo-EM
K Marcus, Y Huang, S Subramanian, CL Gee, K Gorday, ...
Nature structural & molecular biology 31 (3), 424-435, 2024
12024
Improving antibody affinity using laboratory data with language model guided design
B Krause, S Subramanian, T Yuan, M Yang, A Sato, N Naik
bioRxiv, 2023.09. 13.557505, 2023
12023
Adaptive capacity of a DNA polymerase clamp-loader ATPase complex
S Subramanian, W Zhang, S Nimkar, M Kamel, M O’Donnell, J Kuriyan
Molecular Biology and Evolution 41 (3), msae013, 2024
2024
Rescuing from the DEAD: Understanding Substrate-Mediated ATP Hydrolysis through Deep Mutagenesis of a DNA Polymerase Clamp Loader
K Marcus, Y Huang, S Subramanian, K Gorday, S Ghaffari-Kashani, ...
PROTEIN SCIENCE 32 (12), 2023
2023
Directed Evolution Platform in Bacteriophage T4
W Zhang, S Subramanian, M Kamel, J Kuriyan
PROTEIN SCIENCE 32, 2023
2023
Exploring Nucleotide Dependence of DNA Binding in the T4 Bacteriophage Clamp Loader
S Ghaffari-Kashani, K Marcus, K Gorday, L Luo, S Subramanian, ...
PROTEIN SCIENCE 32, 2023
2023
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Artículos 1–13