| Single-cell transcriptomic analysis of Alzheimer’s disease H Mathys, J Davila-Velderrain, Z Peng, F Gao, S Mohammadi, JZ Young, ... Nature 570 (7761), 332-337, 2019 | 2074 | 2019 |
| Gamma frequency entrainment attenuates amyloid load and modifies microglia HF Iaccarino, AC Singer, AJ Martorell, A Rudenko, F Gao, TZ Gillingham, ... Nature 540 (7632), 230-235, 2016 | 1234 | 2016 |
| Temporal tracking of microglia activation in neurodegeneration at single-cell resolution H Mathys, C Adaikkan, F Gao, JZ Young, E Manet, M Hemberg, ... Cell reports 21 (2), 366-380, 2017 | 685 | 2017 |
| Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer’s disease E Gjoneska, AR Pfenning, H Mathys, G Quon, A Kundaje, LH Tsai, ... Nature 518 (7539), 365-369, 2015 | 617 | 2015 |
| Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation MR Fabian, G Mathonnet, T Sundermeier, H Mathys, JT Zipprich, ... Molecular cell 35 (6), 868-880, 2009 | 542 | 2009 |
| miRNA repression involves GW182-mediated recruitment of CCR4–NOT through conserved W-containing motifs M Chekulaeva, H Mathys, JT Zipprich, J Attig, M Colic, R Parker, ... Nature structural & molecular biology 18 (11), 1218-1226, 2011 | 431 | 2011 |
| Gamma entrainment binds higher-order brain regions and offers neuroprotection C Adaikkan, SJ Middleton, A Marco, PC Pao, H Mathys, DNW Kim, F Gao, ... Neuron 102 (5), 929-943. e8, 2019 | 381 | 2019 |
| Structural and biochemical insights to the role of the CCR4-NOT complex and DDX6 ATPase in microRNA repression H Mathys, J Basquin, S Ozgur, M Czarnocki-Cieciura, F Bonneau, ... Molecular cell 54 (5), 751-765, 2014 | 376 | 2014 |
| Posttranscriptional gene regulation by spatial rearrangement of the 3′ untranslated region AB Eberle, L Stalder, H Mathys, RZ Orozco, O Mühlemann PLoS biology 6 (4), e92, 2008 | 327 | 2008 |
| APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes JW Blanchard, LA Akay, J Davila-Velderrain, D von Maydell, H Mathys, ... Nature 611 (7937), 769-779, 2022 | 283 | 2022 |
| Reconstruction of the human blood–brain barrier in vitro reveals a pathogenic mechanism of APOE4 in pericytes JW Blanchard, M Bula, J Davila-Velderrain, LA Akay, L Zhu, A Frank, ... Nature medicine 26 (6), 952-963, 2020 | 239 | 2020 |
| Single-cell dissection of the human brain vasculature FJ Garcia, N Sun, H Lee, B Godlewski, H Mathys, K Galani, B Zhou, ... Nature 603 (7903), 893-899, 2022 | 212 | 2022 |
| Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer’s disease pathology H Mathys, Z Peng, CA Boix, MB Victor, N Leary, S Babu, G Abdelhady, ... Cell 186 (20), 4365-4385. e27, 2023 | 201 | 2023 |
| Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression JT Zipprich, S Bhattacharyya, H Mathys, W Filipowicz Rna 15 (5), 781-793, 2009 | 193 | 2009 |
| Human microglial state dynamics in Alzheimer’s disease progression N Sun, MB Victor, YP Park, X Xiong, AN Scannail, N Leary, S Prosper, ... Cell 186 (20), 4386-4403. e29, 2023 | 156 | 2023 |
| Noninvasive 40-Hz light flicker to recruit microglia and reduce amyloid beta load AC Singer, AJ Martorell, JM Douglas, F Abdurrob, MK Attokaren, J Tipton, ... Nature protocols 13 (8), 1850-1868, 2018 | 112 | 2018 |
| Epigenomic dissection of Alzheimer’s disease pinpoints causal variants and reveals epigenome erosion X Xiong, BT James, CA Boix, YP Park, K Galani, MB Victor, N Sun, L Hou, ... Cell 186 (20), 4422-4437. e21, 2023 | 81 | 2023 |
| AD-linked R47H-TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation FA Sayed, L Kodama, L Fan, GK Carling, JC Udeochu, D Le, Q Li, L Zhou, ... Science translational medicine 13 (622), eabe3947, 2021 | 81 | 2021 |
| Single-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimer’s disease N Sun, LA Akay, MH Murdock, Y Park, F Galiana-Melendez, A Bubnys, ... Nature neuroscience 26 (6), 970-982, 2023 | 73 | 2023 |
| Neuronal DNA double-strand breaks lead to genome structural variations and 3D genome disruption in neurodegeneration V Dileep, CA Boix, H Mathys, A Marco, GM Welch, HS Meharena, A Loon, ... Cell 186 (20), 4404-4421. e20, 2023 | 60 | 2023 |
Manolis KellisProfessor of Computer Science, MIT and Broad InstituteDirección de correo verificada de mit.edu