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Hazheen Shirnekhi
Hazheen Shirnekhi
Blueprint Medicines
Dirección de correo verificada de blueprintmedicines.com
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Phase separation mediates NUP98 fusion oncoprotein leukemic transformation
B Chandra, NL Michmerhuizen, HK Shirnekhi, S Tripathi, BJ Pioso, ...
Cancer discovery 12 (4), 1152-1169, 2022
1032022
Defining the condensate landscape of fusion oncoproteins
S Tripathi, HK Shirnekhi, SD Gorman, B Chandra, DW Baggett, CG Park, ...
Nature communications 14 (1), 6008, 2023
272023
Hyper-active RAS/MAPK introduces cancer-specific mitotic vulnerabilities
JA Herman, RR Romain, P Hoellerbauer, HK Shirnekhi, DC King, ...
Proceedings of the National Academy of Sciences 119 (41), e2208255119, 2022
172022
The role of phase-separated condensates in fusion oncoprotein–driven cancers
HK Shirnekhi, B Chandra, RW Kriwacki
Annual Review of Cancer Biology 7 (1), 73-91, 2023
152023
An image analysis pipeline for quantifying the features of fluorescently-labeled biomolecular condensates in cells
DW Baggett, A Medyukhina, S Tripathi, HK Shirnekhi, H Wu, SB Pounds, ...
Frontiers in Bioinformatics 2, 897238, 2022
122022
Spindle assembly checkpoint signaling and sister chromatid cohesion are disrupted by HPV E6-mediated transformation
HK Shirnekhi, EP Kelley, JG DeLuca, JA Herman
Molecular biology of the cell 28 (15), 2035-2041, 2017
122017
BuGZ facilitates loading of spindle assembly checkpoint proteins to kinetochores in early mitosis
HK Shirnekhi, JA Herman, PJ Paddison, JG DeLuca
Journal of Biological Chemistry 295 (43), 14666-14677, 2020
72020
Phase separation mediates NUP98 fusion oncoprotein leukemic transformation. Cancer Discov. 2022; 12: 1152–1169. doi: 10.1158/2159-8290
B Chandra, NL Michmerhuizen, HK Shirnekhi, S Tripathi, BJ Pioso, ...
CD-21-0674.[Europe PMC free article][Abstract][CrossRef][Academic Search], 0
5
Dissolving Fusion Oncoprotein Condensates to Reverse Aberrant Gene Expression
HK Shirnekhi, B Chandra, RW Kriwacki
Cancer Research 83 (20), 3324-3326, 2023
12023
AML-158 Phase Separation Mediates NUP98 Fusion Oncoprotein Leukemic Transformation
N Michmerhuizen, B Chandra, H Shirnekhi, S Tripathi, B Pioso, D Baggett, ...
Clinical Lymphoma Myeloma and Leukemia 22, S220, 2022
12022
Disruption of cotranscriptional splicing suggests RBM39 is a therapeutic target in acute lymphoblastic leukemia
Q Jin, E Harris, JA Myers, R Mehmood, A Cotton, HK Shirnekhi, ...
Blood 144 (23), 2417-2431, 2024
2024
EPEN-22. ZFTA FUSION ONCOPROTEINS DRIVE ONCOGENESIS THROUGH ASSEMBLY OF BIOMOLECULAR CONDENSATES
S Varadharajan, A Arabzade, HK Shirnekhi, S Ippagunta, N Laboe, D Gee, ...
Neuro-Oncology 26 (Suppl 4), 0, 2024
2024
ZFTA fusion oncoproteins drive tumorigenesis through transcriptional condensates
A Arabzade, H Shirnekhi, S Varadharajan, S Ippagunta, N Laboe, D Gee, ...
2024
Understanding condensate formation by fusion oncoprotein-derived intrinsically disordered regions
S Kinger, BJ Pioso, S Tripathi, AH Phillips, CG Park, S Maiti, SD Gorman, ...
Biophysical Journal 122 (3), 345a, 2023
2023
Defining the condensate landscape of fusion oncoproteins
DW Baggett, H Shirnekhi, B Chandra, S Tripathi, BJ Pioso, R Kriwacki
Biophysical Journal 122 (3), 486a, 2023
2023
Phase separation underlies interactions of the SARS-CoV-2 nucleocapsid protein with nucleoli
P Dogra, H Shirnekhi, MC Ferrolino, M Tolbert, CG Park, RW Kriwacki
Biophysical Journal 122 (3), 205a, 2023
2023
Poster: AML-158 Phase Separation Mediates NUP98 Fusion Oncoprotein Leukemic Transformation
N Michmerhuizen, B Chandra, H Shirnekhi, S Tripathi, B Pioso, D Baggett, ...
Clinical Lymphoma, Myeloma and Leukemia 22, S129, 2022
2022
The role of phase separation by NUP98 fusion oncoproteins in leukemia
B Chandra, N Michmerhuizen, H Shirnekhi, S Tripathi, B Pioso, ...
Biophysical Journal 121 (3), 357a, 2022
2022
Understanding the mechanism of TCF3-HLF fusion oncoprotein-driven leukemogenesis
HK Shirnekhi, SD Gorman, NL Michmerhuizen, S Tripathi, A Medyukhina, ...
Biophysical Journal 121 (3), 356a, 2022
2022
Are fusion oncoproteins a source of disease-relevant, phase separation-prone protein regions?
SD Gorman, H Shirnekhi, R Somjee, S Tripathi, CG Park, AH Phillips, ...
Biophysical Journal 121 (3), 307a, 2022
2022
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