| In vitro models of the blood–brain barrier: an overview of commonly used brain endothelial cell culture models and guidelines for their use HC Helms, NJ Abbott, M Burek, R Cecchelli, PO Couraud, MA Deli, ... Journal of Cerebral Blood Flow & Metabolism 36 (5), 862-890, 2016 | 819 | 2016 |
| Semaglutide lowers body weight in rodents via distributed neural pathways S Gabery, CG Salinas, SJ Paulsen, J Ahnfelt-Rønne, T Alanentalo, ... JCI insight 5 (6), 2020 | 450 | 2020 |
| In vitro evidence for the brain glutamate efflux hypothesis: Brain endothelial cells cocultured with astrocytes display a polarized brain‐to‐blood transport of glutamate HC Helms, R Madelung, HS Waagepetersen, CU Nielsen, B Brodin Glia 60 (6), 882-893, 2012 | 94 | 2012 |
| Tight junctions in the blood–brain barrier promote edema formation and infarct size in stroke–ambivalent effects of sealing proteins L Winkler, R Blasig, O Breitkreuz-Korff, P Berndt, S Dithmer, HC Helms, ... Journal of Cerebral Blood Flow & Metabolism 41 (1), 132-145, 2021 | 84 | 2021 |
| Precapillary sphincters and pericytes at first-order capillaries as key regulators for brain capillary perfusion SA Zambach, C Cai, HCC Helms, BO Hald, Y Dong, JC Fordsmann, ... Proceedings of the National Academy of Sciences 118 (26), e2023749118, 2021 | 81 | 2021 |
| Sodium caprate transiently opens claudin-5-containing barriers at tight junctions of epithelial and endothelial cells G Del Vecchio, C Tscheik, K Tenz, HC Helms, L Winkler, R Blasig, ... Molecular pharmaceutics 9 (9), 2523-2533, 2012 | 81 | 2012 |
| Paracellular tightness and claudin-5 expression is increased in the BCEC/astrocyte blood–brain barrier model by increasing media buffer capacity during growth HC Helms, HS Waagepetersen, CU Nielsen, B Brodin The AAPS journal 12, 759-770, 2010 | 81 | 2010 |
| Tanycytes control hypothalamic liraglutide uptake and its anti-obesity actions M Imbernon, C Saponaro, HCC Helms, M Duquenne, D Fernandois, ... Cell metabolism 34 (7), 1054-1063. e7, 2022 | 64 | 2022 |
| Effects of oxygen-glucose deprivation (OGD) on barrier properties and mRNA transcript levels of selected marker proteins in brain endothelial cells/astrocyte co-cultures E Tornabene, HCC Helms, SF Pedersen, B Brodin PloS one 14 (8), e0221103, 2019 | 63 | 2019 |
| An Electrically Tight In Vitro Blood–Brain Barrier Model Displays Net Brain-to-Blood Efflux of Substrates for the ABC Transporters, P-gp, Bcrp and Mrp-1 HC Helms, M Hersom, LB Kuhlmann, L Badolo, CU Nielsen, B Brodin The AAPS journal 16, 1046-1055, 2014 | 61 | 2014 |
| The insulin receptor is expressed and functional in cultured blood-brain barrier endothelial cells but does not mediate insulin entry from blood to brain M Hersom, HC Helms, C Schmalz, TÅ Pedersen, ST Buckley, B Brodin American Journal of Physiology-Endocrinology and Metabolism 315 (4), E531-E542, 2018 | 49 | 2018 |
| In vitro blood–brain barrier permeability predictions for GABAA receptor modulating piperine analogs DE Eigenmann, C Dürig, EA Jähne, M Smieško, M Culot, F Gosselet, ... European Journal of Pharmaceutics and Biopharmaceutics 103, 118-126, 2016 | 47 | 2016 |
| Transferrin receptor expression and role in transendothelial transport of transferrin in cultured brain endothelial monolayers M Hersom, HC Helms, N Pretzer, C Goldeman, AI Jensen, G Severin, ... Molecular and Cellular Neuroscience 76, 59-67, 2016 | 44 | 2016 |
| Glutamate efflux at the blood–brain barrier: cellular mechanisms and potential clinical relevance HHC Cederberg, NC Uhd, B Brodin Archives of medical research 45 (8), 639-645, 2014 | 42 | 2014 |
| Generation of Primary cultures of Bovine Brain Endothelial cells and setup of Co-Cultures with Rat Astrocytes HC Helms, B Brodin Methods in Molecular Biology, 2014 | 42 | 2014 |
| Hypoxia increases expression of selected blood–brain barrier transporters GLUT-1, P-gp, SLC7A5 and TFRC, while maintaining barrier integrity, in brain capillary endothelial … B Ozgür, HCC Helms, E Tornabene, B Brodin Fluids and Barriers of the CNS 19 (1), 1, 2022 | 33 | 2022 |
| IPEC-J2 MDR1, a novel high-resistance cell line with functional expression of human P-glycoprotein (ABCB1) for drug screening studies L Saaby, HCC Helms, B Brodin Molecular Pharmaceutics 13 (2), 640-652, 2016 | 33 | 2016 |
| Conjugation of therapeutic psd-95 inhibitors to the cell-penetrating peptide tat affects blood–brain barrier adherence, uptake, and permeation M Kristensen, K Kucharz, E Felipe Alves Fernandes, K Strømgaard, ... Pharmaceutics 12 (7), 661, 2020 | 26 | 2020 |
| Drug delivery strategies to overcome the blood–brain barrier (BBB) HCC Helms, M Kristensen, L Saaby, G Fricker, B Brodin Physiology, Pharmacology and Pathology of the Blood-Brain Barrier, 151-183, 2020 | 25 | 2020 |
| ATP induces contraction of cultured brain capillary pericytes via activation of P2Y-type purinergic receptors S Hørlyck, C Cai, HCC Helms, M Lauritzen, B Brodin American Journal of Physiology-Heart and Circulatory Physiology 320 (2 …, 2021 | 23 | 2021 |
Birger BrodinProfessor, CNS drug delivery, University of CopenhagenDirección de correo verificada de sund.ku.dk