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Isaac Witte
Isaac Witte
Dirección de correo verificada de g.harvard.edu
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Programmed DNA destruction by miniature CRISPR-Cas14 enzymes
LB Harrington, D Burstein, JS Chen, D Paez-Espino, E Ma, IP Witte, ...
Science 362 (6416), 839-842, 2018
10752018
Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors
JR Davis, X Wang, IP Witte, TP Huang, JM Levy, A Raguram, S Banskota, ...
Nature Biomedical Engineering 6 (11), 1272-1283, 2022
1252022
CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks
JC Cofsky, D Karandur, CJ Huang, IP Witte, J Kuriyan, JA Doudna
Elife 9, e55143, 2020
942020
A scoutRNA is required for some type V CRISPR-Cas systems
LB Harrington, E Ma, JS Chen, IP Witte, D Gertz, D Paez-Espino, ...
Molecular cell 79 (3), 416-424. e5, 2020
712020
Site-specific lipidation enhances IFITM3 membrane interactions and antiviral activity
EH Garst, H Lee, T Das, S Bhattacharya, A Percher, R Wiewiora, IP Witte, ...
ACS chemical biology 16 (5), 844-856, 2021
292021
Programmable nuclease improvements and compositions and methods for nucleic acid amplification and detection
LB Harrington, JS Chen, JP Broughton, PPD Galarza, WJ Hartono, ...
US Patent 11,174,470, 2021
182021
Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors. Nat Biomed Eng. 2022; 6: 1272–1283
JR Davis, X Wang, IP Witte, TP Huang, JM Levy, A Raguram
5
Efficient in vivo base editing via single adenoassociated viruses with size-optimized genomes encoding compact adenine base editors (Jul, 10.1038/s41551-022-00911-4, 2022)
JR Davis, X Wang, IP Witte, TP Huang, JM Levy, A Raguram, S Banskota, ...
Nature Biomedical Engineering 6 (11), 1317-1317, 2022
22022
Publisher Correction: Efficient in vivo base editing via single adenoassociated viruses with size-optimized genomes encoding compact adenine base editors
JR Davis, X Wang, IP Witte, TP Huang, JM Levy, A Raguram, S Banskota, ...
Nature Biomedical Engineering 6 (11), 1317, 2022
22022
Programmable nucleases and methods of use
LB Harrington, JS Chen, IP Witte
US Patent App. 17/516,027, 2022
12022
PROGRAMMABLE NUCLEASES AND METHODS OF USE
LB Harrington, JS Chen, IP Witte
US Patent App. 18/584,462, 2024
2024
COMPOSITIONS AND METHODS FOR DETECTING MODIFIED NUCLEIC ACIDS AND AMPLIFYING ssDNA
LB Harrington, JS Chen, JP Broughton, IP Witte
US Patent App. 17/365,967, 2022
2022
Programmable nuclease improvements and compositions and methods for nucleic acid amplification and detection
LB Harrington, JS Chen, JP Broughton, PPD Galarza, WJ Hartono, ...
US Patent App. 17/495,652, 2022
2022
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