Efficient generation of Rosa26 knock-in mice using CRISPR/Cas9 in C57BL/6 zygotes VT Chu, T Weber, R Graf, T Sommermann, K Petsch, U Sack, P Volchkov, ... BMC biotechnology 16, 1-15, 2016 | 326 | 2016 |
PI3 kinase and FOXO1 transcription factor activity differentially control B cells in the germinal center light and dark zones S Sander, T Yasuda, A Franklin, R Graf, DP Calado, S Li, K Imami, ... Immunity 43 (6), 1075-1086, 2015 | 271 | 2015 |
Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line VT Chu, R Graf, T Wirtz, T Weber, J Favret, X Li, K Petsch, NT Tran, ... Proceedings of the National Academy of Sciences 113 (44), 12514-12519, 2016 | 158 | 2016 |
sgRNA sequence motifs blocking efficient CRISPR/Cas9-mediated gene editing R Graf, X Li, K Rajewsky Cell reports 26 (5), 1098-1103. e3, 2019 | 132 | 2019 |
BCR-dependent lineage plasticity in mature B cells R Graf, J Seagal, KL Otipoby, KP Lam, S Ayoub, B Zhang, S Sander, ... Science 363 (6428), 748-753, 2019 | 101 | 2019 |
Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation R Graf, M Munschauer, G Mastrobuoni, F Mayr, U Heinemann, S Kempa, ... RNA biology 10 (7), 1146-1159, 2013 | 88 | 2013 |
Efficient CRISPR/Cas9-mediated gene knockin in mouse hematopoietic stem and progenitor cells NT Tran, T Sommermann, R Graf, J Trombke, J Pempe, K Petsch, R Kühn, ... Cell reports 28 (13), 3510-3522. e5, 2019 | 36 | 2019 |
CRISPR-Cas9-mediated ELANE mutation correction in hematopoietic stem and progenitor cells to treat severe congenital neutropenia NT Tran, R Graf, A Wulf-Goldenberg, M Stecklum, G Strauß, R Kühn, ... Molecular Therapy 28 (12), 2621-2634, 2020 | 35 | 2020 |
Precise CRISPR-Cas–mediated gene repair with minimal off-target and unintended on-target mutations in human hematopoietic stem cells NT Tran, E Danner, X Li, R Graf, M Lebedin, K de la Rosa, R Kühn, ... Science Advances 8 (22), eabm9106, 2022 | 28 | 2022 |
B-cell-specific Myd88 L252P expression causes a premalignant gammopathy resembling IgM MGUS K Schmidt, U Sack, R Graf, W Winkler, O Popp, P Mertins, T Sommermann, ... Frontiers in Immunology 11, 602868, 2020 | 14 | 2020 |
PDGFA-associated protein 1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification V Delgado-Benito, M Berruezo-Llacuna, R Altwasser, W Winkler, ... Journal of Experimental Medicine 217 (10), e20200137, 2020 | 12 | 2020 |
sgRNA sequence motifs blocking efficient CRISPR/Cas9-mediated gene editing. Cell Rep 26: 1098–1103 R Graf, X Li, VT Chu, K Rajewsky | 8 | 2019 |
CRISPR/Cas9-mediated in vitro mutagenesis in GC-like B cells VT Chu, R Graf, K Rajewsky Germinal Centers: Methods and Protocols, 135-145, 2017 | 7 | 2017 |
Gene-editing in patient and humanized-mice primary muscle stem cells rescues dysferlin expression in dysferlin-deficient muscular dystrophy H Escobar, S Di Francescantonio, J Smirnova, R Graf, S Müthel, A Marg, ... Nature Communications 16 (1), 120, 2025 | | 2025 |
In vivo CRISPR/Cas9-mediated screen reveals a critical function of TFDP1 and E2F4 transcription factors in hematopoiesis NT Tran, R Graf, E Acevedo-Ochoa, J Trombke, T Weber, T Sommermann, ... Leukemia 38 (9), 2003-2015, 2024 | | 2024 |
Spacer-Nick: Precise Gene Correction in Human Primary Cells with Minimal Off-Target and Unintended On-Target Mutations NT Tran, EE Danner, X Li, R Graf, M Lebedin, K de la Rosa, R Kuehn, ... MOLECULAR THERAPY 30 (4), 458-458, 2022 | | 2022 |
Systematic Genomic Safety Assessment of CRISPR-Based Gene Therapy in Muscle Stem Cells R Graf, C Stadelmann, HE Fernandez, S Spuler MOLECULAR THERAPY 30 (4), 544-544, 2022 | | 2022 |
Molecular characterization of dormant and activated hematopoietic stem cells R Graf | | 2010 |