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Raajaram Gowrishankar
Raajaram Gowrishankar
Dirección de correo verificada de uw.edu
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Antipsychotic drug-like effects of the selective M4 muscarinic acetylcholine receptor positive allosteric modulator VU0152100
NE Byun, M Grannan, M Bubser, RL Barry, A Thompson, J Rosanelli, ...
Neuropsychopharmacology 39 (7), 1578-1593, 2014
1352014
The rare DAT coding variant Val559 perturbs DA neuron function, changes behavior, and alters in vivo responses to psychostimulants
MA Mergy, R Gowrishankar, PJ Gresch, SC Gantz, J Williams, GL Davis, ...
Proceedings of the National Academy of Sciences 111 (44), E4779-E4788, 2014
872014
Ventral tegmental area GABAergic inhibition of cholinergic interneurons in the ventral nucleus accumbens shell promotes reward reinforcement
R Al-Hasani, R Gowrishankar, GP Schmitz, CE Pedersen, DJ Marcus, ...
Nature neuroscience 24 (10), 1414-1428, 2021
862021
Good riddance to dopamine: roles for the dopamine transporter in synaptic function and dopamine-associated brain disorders
R Gowrishankar, MK Hahn, RD Blakely
Neurochemistry international 73, 42-48, 2014
822014
A photoswitchable GPCR-based opsin for presynaptic inhibition
BA Copits, R Gowrishankar, PR O’Neill, JN Li, KS Girven, JJ Yoo, ...
Neuron 109 (11), 1791-1809. e11, 2021
772021
Region-specific regulation of presynaptic dopamine homeostasis by D2 autoreceptors shapes the in vivo impact of the neuropsychiatric disease-associated DAT variant Val559
R Gowrishankar, PJ Gresch, GL Davis, RM Katamish, JR Riele, ...
Journal of Neuroscience 38 (23), 5302-5312, 2018
502018
Genetic targeting of the amphetamine and methylphenidate-sensitive dopamine transporter: on the path to an animal model of attention-deficit hyperactivity disorder
MA Mergy, R Gowrishankar, GL Davis, TN Jessen, J Wright, ...
Neurochemistry international 73, 56-70, 2014
382014
Functional coding variation in the presynaptic dopamine transporter associated with neuropsychiatric disorders drives enhanced motivation and context-dependent impulsivity in mice
GL Davis, A Stewart, GD Stanwood, R Gowrishankar, MK Hahn, ...
Behavioural brain research 337, 61-69, 2018
372018
Serotonin transporter inhibition and 5-HT2C receptor activation drive loss of cocaine-induced locomotor activation in DAT Val559 mice
A Stewart, GL Davis, PJ Gresch, RM Katamish, R Peart, MJ Rabil, ...
Neuropsychopharmacology 44 (5), 994-1006, 2019
232019
A bistable inhibitory optoGPCR for multiplexed optogenetic control of neural circuits
J Wietek, A Nozownik, M Pulin, I Saraf-Sinik, N Matosevich, ...
Nature Methods, 1-13, 2024
162024
An open-source platform for head-fixed operant and consummatory behavior
A Gordon-Fennell, JM Barbakh, MKT Utley, S Singh, P Bazzino, ...
Elife 12, e86183, 2023
132023
Behaviorally penetrant, anomalous dopamine efflux exposes sex and circuit dependent regulation of dopamine transporters
A Stewart, FP Mayer, R Gowrishankar, GL Davis, LB Areal, PJ Gresch, ...
Molecular Psychiatry 27 (12), 4869-4880, 2022
102022
Medial accumbens shell spiny projection neurons encode relative reward preference
CE Pedersen, R Gowrishankar, SC Piantadosi, DC Castro, MM Gray, ...
bioRxiv, 2022.09. 18.508426, 2022
82022
Phylogenetic comparison of exonic US4, US7 and UL44 regions of clinical herpes simplex virus type 1 isolates showed lack of association between their anatomic sites of …
A Harishankar, M Jambulingam, R Gowrishankar, A Venkatachalam, ...
Virology journal 9, 1-8, 2012
82012
Sex and Circuit Specific Dopamine Transporter Regulation Underlies Unique Behavioral Trajectories of Functional SLC6A3 Coding Variation
A Stewart, FP Mayer, R Gowrishankar, GL Davis, LB Areal, PJ Gresch, ...
bioRxiv, 2021.11. 02.466932, 2021
62021
Unlocking opioid neuropeptide dynamics with genetically-encoded biosensors
L Tian, C Dong, R Gowrishankar, Y Jin, X He, A Gupta, H Wang, N Atasoy, ...
52023
Kappa opioid receptor antagonism rescues genetic perturbation of dopamine homeostasis: Molecular, physiological and behavioral consequences
FP Mayer, A Stewart, DR Varman, AE Moritz, JD Foster, AW Owens, ...
BioRxiv, 2023
52023
Unlocking opioid neuropeptide dynamics with genetically encoded biosensors
C Dong, R Gowrishankar, Y Jin, XJ He, A Gupta, H Wang, N Sayar-Atasoy, ...
Nature neuroscience 27 (9), 1844-1857, 2024
42024
Ventral tegmental area GABAergic inhibition of ventral accumbens shell cholinergic interneurons promotes reward reinforcement
R Al-Hasani, R Gowrishankar, GP Schmitz, CE Pedersen, DJ Marcus, ...
Nature neuroscience 24 (10), 1414, 2021
42021
Kappa-opioid receptor activation reinstates nicotine self-administration in mice
R Gowrishankar, A Gomez, M Waliki, MR Bruchas
Addiction neuroscience 2, 100017, 2022
32022
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Artículos 1–20