Hierarchical modularity and the evolution of genetic interactomes across species CJ Ryan, A Roguev, K Patrick, J Xu, H Jahari, Z Tong, P Beltrao, M Shales, ... Molecular cell 46 (5), 691-704, 2012 | 239 | 2012 |
Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis CG Weindel, EL Martinez, X Zhao, CJ Mabry, SL Bell, KJ Vail, ... Cell 185 (17), 3214-3231. e23, 2022 | 216 | 2022 |
LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis CG Weindel, SL Bell, KJ Vail, KO West, KL Patrick, RO Watson Elife 9, e51071, 2020 | 119 | 2020 |
Exploring the “multiple-hit hypothesis” of neurodegenerative disease: bacterial infection comes up to bat KL Patrick, SL Bell, CG Weindel, RO Watson Frontiers in Cellular and Infection Microbiology 9, 138, 2019 | 98 | 2019 |
Distinct and overlapping roles for two Dicer-like proteins in the RNA interference pathways of the ancient eukaryote Trypanosoma brucei KL Patrick, H Shi, NG Kolev, K Ersfeld, C Tschudi, E Ullu Proceedings of the National Academy of Sciences 106 (42), 17933-17938, 2009 | 81 | 2009 |
The splicing factor hnRNP M is a critical regulator of innate immune gene expression in macrophages KO West, HM Scott, S Torres-Odio, AP West, KL Patrick, RO Watson Cell reports 29 (6), 1594-1609. e5, 2019 | 79 | 2019 |
Galectin-8 Senses Phagosomal Damage and Recruits Selective Autophagy Adapter TAX1BP1 To Control Mycobacterium tuberculosis Infection in Macrophages SL Bell, KL Lopez, JS Cox, KL Patrick, RO Watson MBio 12 (4), 10.1128/mbio. 01871-20, 2021 | 58 | 2021 |
TRIM14 is a key regulator of the type I IFN response during Mycobacterium tuberculosis infection CT Hoffpauir, SL Bell, KO West, T Jing, AR Wagner, S Torres-Odio, ... The Journal of Immunology 205 (1), 153-167, 2020 | 56 | 2020 |
Genetic interaction mapping reveals a role for the SWI/SNF nucleosome remodeler in spliceosome activation in fission yeast KL Patrick, CJ Ryan, J Xu, JJ Lipp, KE Nissen, A Roguev, M Shales, ... PLoS genetics 11 (3), e1005074, 2015 | 35 | 2015 |
The histone variant H2A. Z promotes splicing of weak introns KE Nissen, CM Homer, CJ Ryan, M Shales, NJ Krogan, KL Patrick, ... Genes & development 31 (7), 688-701, 2017 | 30 | 2017 |
454 life sciences: Illuminating the future of genome sequencing and personalized medicine KL Patrick The Yale journal of biology and medicine 80 (4), 191, 2008 | 30 | 2008 |
Genomic rearrangements and transcriptional analysis of the spliced leader‐associated retrotransposon in RNA interference‐deficient Trypanosoma brucei KL Patrick, PM Luz, J Ruan, H Shi, E Ullu, C Tschudi Molecular microbiology 67 (2), 435-447, 2008 | 30 | 2008 |
For Better or Worse: Cytosolic DNA Sensing during Intracellular Bacterial Infection Induces Potent Innate Immune Responses KL Patrick, SL Bell, RO Watson Journal of Molecular Biology 428 (17), 3372–3386, 2016 | 29 | 2016 |
Protein arginine methyltransferase 5 in T lymphocyte biology S Sengupta, A Kennemer, K Patrick, P Tsichlis, M Guerau-de-Arellano Trends in immunology 41 (10), 918-931, 2020 | 28 | 2020 |
Global transcriptomics uncovers distinct contributions from splicing regulatory proteins to the macrophage innate immune response AR Wagner, HM Scott, KO West, KJ Vail, TC Fitzsimons, AK Coleman, ... Frontiers in Immunology 12, 656885, 2021 | 27* | 2021 |
Mitochondria: powering the innate immune response to Mycobacterium tuberculosis infection KL Patrick, RO Watson Infection and immunity 89 (4), 10.1128/iai. 00687-20, 2021 | 25 | 2021 |
Quantitative yeast genetic interaction profiling of bacterial effector proteins uncovers a role for the human retromer in Salmonella infection KL Patrick, JA Wojcechowskyj, SL Bell, MN Riba, T Jing, S Talmage, P Xu, ... Cell systems 7 (3), 323-338. e6, 2018 | 24 | 2018 |
Gasdermins gone wild: new roles for GSDMs in regulating cellular homeostasis CG Weindel, LM Ellzey, EL Martinez, RO Watson, KL Patrick Trends in cell biology 33 (9), 773-787, 2023 | 17 | 2023 |
The opportunistic intracellular bacterial pathogen Rhodococcus equi elicits type I interferon by engaging cytosolic DNA sensing in macrophages KJ Vail, BP da Silveira, SL Bell, ND Cohen, AI Bordin, KL Patrick, ... PLoS pathogens 17 (9), e1009888, 2021 | 14 | 2021 |
PRMT5 promotes symmetric dimethylation of RNA processing proteins and modulates activated T cell alternative splicing and Ca2+/NFAT signaling S Sengupta, KO West, S Sanghvi, G Laliotis, LM Agosto, KW Lynch, ... Immunohorizons 5 (10), 884-897, 2021 | 11 | 2021 |