| Identification of human brain tumour initiating cells SK Singh, C Hawkins, ID Clarke, JA Squire, J Bayani, T Hide, ... nature 432 (7015), 396-401, 2004 | 9450 | 2004 |
| Identification of a cancer stem cell in human brain tumors SK Singh, ID Clarke, M Terasaki, VE Bonn, C Hawkins, J Squire, PB Dirks Cancer research 63 (18), 5821-5828, 2003 | 7030 | 2003 |
| Cancer stem cells—perspectives on current status and future directions: AACR Workshop on cancer stem cells MF Clarke, JE Dick, PB Dirks, CJ Eaves, CHM Jamieson, DL Jones, ... Cancer research 66 (19), 9339-9344, 2006 | 4088 | 2006 |
| High-resolution CRISPR screens reveal fitness genes and genotype-specific cancer liabilities T Hart, M Chandrashekhar, M Aregger, Z Steinhart, KR Brown, ... Cell 163 (6), 1515-1526, 2015 | 1717 | 2015 |
| Cancer stem cells: an evolving concept LV Nguyen, R Vanner, P Dirks, CJ Eaves Nature Reviews Cancer 12 (2), 133-143, 2012 | 1416 | 2012 |
| Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens SM Pollard, K Yoshikawa, ID Clarke, D Danovi, S Stricker, R Russell, ... Cell stem cell 4 (6), 568-580, 2009 | 1190 | 2009 |
| Intertumoral heterogeneity within medulloblastoma subgroups FMG Cavalli, M Remke, L Rampasek, J Peacock, DJH Shih, B Luu, ... Cancer cell 31 (6), 737-754. e6, 2017 | 1166 | 2017 |
| Tumour-initiating cells: challenges and opportunities for anticancer drug discovery BBS Zhou, H Zhang, M Damelin, KG Geles, JC Grindley, PB Dirks Nature reviews Drug discovery 8 (10), 806-823, 2009 | 1088 | 2009 |
| Subgroup-specific structural variation across 1,000 medulloblastoma genomes PA Northcott, DJH Shih, J Peacock, L Garzia, A Sorana Morrissy, ... Nature 488 (7409), 49-56, 2012 | 1014 | 2012 |
| Cancer stem cells in nervous system tumors SK Singh, ID Clarke, T Hide, PB Dirks Oncogene 23 (43), 7267-7273, 2004 | 968 | 2004 |
| Immune checkpoint inhibition for hypermutant glioblastoma multiforme resulting from germline biallelic mismatch repair deficiency E Bouffet, V Larouche, BB Campbell, D Merico, R De Borja, M Aronson, ... Journal of clinical oncology 34 (19), 2206-2211, 2016 | 898 | 2016 |
| Hypothermia therapy after traumatic brain injury in children JS Hutchison, RE Ward, J Lacroix, PC Hébert, MA Barnes, DJ Bohn, ... New England Journal of Medicine 358 (23), 2447-2456, 2008 | 777 | 2008 |
| Comprehensive analysis of hypermutation in human cancer BB Campbell, N Light, D Fabrizio, M Zatzman, F Fuligni, R de Borja, ... Cell 171 (5), 1042-1056. e10, 2017 | 769 | 2017 |
| Epigenomic alterations define lethal CIMP-positive ependymomas of infancy SC Mack, H Witt, RM Piro, L Gu, S Zuyderduyn, AM Stütz, X Wang, ... Nature 506 (7489), 445-450, 2014 | 671 | 2014 |
| Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy X Lan, DJ Jörg, FMG Cavalli, LM Richards, LV Nguyen, RJ Vanner, ... Nature 549 (7671), 227-232, 2017 | 470 | 2017 |
| Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity M Meyer, J Reimand, X Lan, R Head, X Zhu, M Kushida, J Bayani, ... Proceedings of the National Academy of Sciences 112 (3), 851-856, 2015 | 439 | 2015 |
| Childhood cerebellar tumours mirror conserved fetal transcriptional programs MC Vladoiu, I El-Hamamy, LK Donovan, H Farooq, BL Holgado, ... Nature 572 (7767), 67-73, 2019 | 415 | 2019 |
| Endoscopic third ventriculostomy in the treatment of childhood hydrocephalus AV Kulkarni, J Drake J, CL Mallucci, S Sgouros, J Roth, S Constantini, ... The Journal of pediatrics 155 (2), 254-9, 2009 | 407 | 2009 |
| Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers A Shlien, BB Campbell, R De Borja, LB Alexandrov, D Merico, D Wedge, ... Nature genetics 47 (3), 257-262, 2015 | 400 | 2015 |
| Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis EM Thompson, T Hielscher, E Bouffet, M Remke, B Luu, S Gururangan, ... The lancet oncology 17 (4), 484-495, 2016 | 395 | 2016 |
