| ONC201 and imipridones: Anti-cancer compounds with clinical efficacy VV Prabhu, S Morrow, AR Kawakibi, L Zhou, M Ralff, J Ray, A Jhaveri, ... Neoplasia 22 (12), 725-744, 2020 | 147 | 2020 |
| Immunotherapy for colorectal cancer: mechanisms and predictive biomarkers L Carlsen, KE Huntington, WS El-Deiry Cancers 14 (4), 1028, 2022 | 48 | 2022 |
| Chitinase 3-like-1 is a therapeutic target that mediates the effects of aging in COVID-19 S Kamle, B Ma, CH He, B Akosman, Y Zhou, CM Lee, WS El-Deiry, ... JCI insight 6 (21), 2021 | 35 | 2021 |
| Integrating molecular biomarker inputs into development and use of clinical cancer therapeutics AD Louie, K Huntington, L Carlsen, L Zhou, WS El-Deiry Frontiers in Pharmacology 12, 747194, 2021 | 33 | 2021 |
| Therapeutic targeting of TRAIL death receptors F Di Cristofano, A George, V Tajiknia, M Ghandali, L Wu, Y Zhang, ... Biochemical Society Transactions 51 (1), 57-70, 2023 | 29 | 2023 |
| Cytokine ranking via mutual information algorithm correlates cytokine profiles with presenting disease severity in patients infected with SARS-CoV-2 KE Huntington, AD Louie, CG Lee, JA Elias, EA Ross, WS El-Deiry Elife 10, e64958, 2021 | 27 | 2021 |
| MEK inhibitors reduce cellular expression of ACE2, pERK, pRb while stimulating NK-mediated cytotoxicity and attenuating inflammatory cytokines relevant to SARS-CoV-2 infection L Zhou, K Huntington, S Zhang, L Carlsen, EY So, C Parker, I Sahin, ... Oncotarget 11 (46), 4201, 2020 | 25 | 2020 |
| Timing and cell specificity of senescence drives postnatal lung development and injury H Yao, J Wallace, AL Peterson, A Scaffa, S Rizal, K Hegarty, H Maeda, ... Nature Communications 14 (1), 273, 2023 | 24 | 2023 |
| Colorectal cancer extracellular acidosis decreases immune cell killing and is partially ameliorated by pH-modulating agents that modify tumor cell cytokine profiles KE Huntington, A Louie, L Zhou, AA Seyhan, AWP Maxwell, WS El-Deiry American Journal of Cancer Research 12 (1), 138, 2022 | 23 | 2022 |
| Integrin/TGF-β1 inhibitor GLPG-0187 blocks SARS-CoV-2 delta and omicron pseudovirus infection of airway epithelial cells in vitro, which could attenuate disease severity KE Huntington, L Carlsen, EY So, M Piesche, O Liang, WS El-Deiry Pharmaceuticals 15 (5), 618, 2022 | 20 | 2022 |
| Clinical activity of 9-ING-41, a small molecule selective glycogen synthase kinase-3 beta (GSK-3β) inhibitor, in refractory adult T-Cell leukemia/lymphoma A Hsu, KE Huntington, A De Souza, L Zhou, AJ Olszewski, NP Makwana, ... Cancer Biology & Therapy 23 (1), 417-423, 2022 | 15 | 2022 |
| Pan-drug and drug-specific mechanisms of 5-FU, irinotecan (CPT-11), oxaliplatin, and cisplatin identified by comparison of transcriptomic and cytokine responses of colorectal … L Carlsen, C Schorl, K Huntington, L Hernandez-Borrero, A Jhaveri, ... Oncotarget 12 (20), 2006, 2021 | 13 | 2021 |
| Chemotherapy-induced cytokines and prognostic gene signatures vary across breast and colorectal cancer L Groysman, L Carlsen, KE Huntington, WH Shen, L Zhou, WS El-Deiry American Journal of Cancer Research 11 (12), 6086, 2021 | 11 | 2021 |
| Natural Killer cell activation, reduced ACE2, TMPRSS2, cytokines G-CSF, M-CSF and SARS-CoV-2-S pseudovirus infectivity by MEK inhibitor treatment of human cells L Zhou, K Huntington, S Zhang, L Carlsen, EY So, C Parker, I Sahin, ... Biorxiv, 2020 | 10 | 2020 |
| GSK-3 inhibitor elraglusib enhances tumor-infiltrating immune cell activation in tumor biopsies and synergizes with anti-PD-L1 in a murine model of colorectal cancer KE Huntington, AD Louie, PR Srinivasan, C Schorl, S Lu, D Silverberg, ... International Journal of Molecular Sciences 24 (13), 10870, 2023 | 9 | 2023 |
| Involvement of miRNA-34a regulated Krüppel-like factor 4 expression in hyperoxia-induced senescence in lung epithelial cells H Maeda, H Yao, H Go, KE Huntington, ME De Paepe, PA Dennery Respiratory Research 23 (1), 340, 2022 | 8 | 2022 |
| GSK3β inhibition by small molecule 9-ING-41 decreases VEGF and other cytokines, and boosts NK and T cell-mediated killing of colorectal tumor cells KE Huntington, S Zhang, BA Carneiro, WS El-Deiry Cancer Research 81 (13_Supplement), 2676-2676, 2021 | 7 | 2021 |
| Synergistic activity of ABT-263 and ONC201/TIC10 against solid tumor cell lines is associated with suppression of anti-apoptotic Mcl-1, BAG3, pAkt, and upregulation of pro … FR Di Cristofano, MW Fong, KE Huntington, BA Carneiro, L Zhou, ... American Journal of Cancer Research 13 (1), 307, 2023 | 6 | 2023 |
| Hyperprogression of a mismatch repair-deficient colon cancer in a humanized mouse model following administration of immune checkpoint inhibitor pembrolizumab I Sahin, A George, S Zhang, KE Huntington, Z Ordulu, L Zhou, ... Oncotarget 12 (21), 2131, 2021 | 6 | 2021 |
| A high-throughput customized cytokinome screen of colon cancer cell responses to small-molecule oncology drugs KE Huntington, A Louie, L Zhou, WS El-Deiry Oncotarget 12 (20), 1980, 2021 | 6 | 2021 |