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| A "Silent" Polymorphism in the MDR1 Gene Changes Substrate Specificity C Kimchi-Sarfaty, JM Oh, IW Kim, ZE Sauna, AM Calcagno, SV Ambudkar, ... Science 315 (5811), 525-528, 2007 | 3088 | 2007 |
| Biochemical, cellular, and pharmacological aspects of the multidrug transporter SV Ambudkar, S Dey, CA Hrycyna, M Ramachandra, I Pastan, ... Annual review of pharmacology and toxicology 39 (1), 361-398, 1999 | 2803 | 1999 |
| P-glycoprotein: from genomics to mechanism SV Ambudkar, C Kimchi-Sarfaty, ZE Sauna, MM Gottesman Oncogene 22 (47), 7468-7485, 2003 | 1434 | 2003 |
| Brca1 breast tumors contain distinct CD44+/CD24- and CD133+cells with cancer stem cell characteristics MH Wright, AM Calcagno, CD Salcido, MD Carlson, SV Ambudkar, ... Breast cancer research 10, 1-16, 2008 | 836 | 2008 |
| Reconstitution of functional water channels in liposomes containing purified red cell CHIP28 protein ML Zeidel, SV Ambudkar, BL Smith, P Agre Biochemistry 31 (33), 7436-7440, 1992 | 732 | 1992 |
| P-glycoprotein and multidrug resistance MM Gottesman, I Pastan, SV Ambudkar Current opinion in genetics & development 6 (5), 610-617, 1996 | 711 | 1996 |
| Redefining the relevance of established cancer cell lines to the study of mechanisms of clinical anti-cancer drug resistance JP Gillet, AM Calcagno, S Varma, M Marino, LJ Green, MI Vora, C Patel, ... Proceedings of the National Academy of Sciences 108 (46), 18708-18713, 2011 | 601 | 2011 |
| HIV-1 Protease Inhibitors Are Substrates for the MDR1 Multidrug Transporter CGL Lee, MM Gottesman, CO Cardarelli, M Ramachandra, KT Jeang, ... Biochemistry 37 (11), 3594-3601, 1998 | 593 | 1998 |
| Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity J Tam, VK Vemuri, J Liu, S Bátkai, B Mukhopadhyay, G Godlewski, ... The Journal of clinical investigation 120 (8), 2953-2966, 2010 | 536 | 2010 |
| Partial purification and reconstitution of the human multidrug-resistance pump: characterization of the drug-stimulatable ATP hydrolysis. SV Ambudkar, IH Lelong, J Zhang, CO Cardarelli, MM Gottesman, ... Proceedings of the National Academy of Sciences 89 (18), 8472-8476, 1992 | 523 | 1992 |
| Overview: ABC transporters and human disease MM Gottesman, SV Ambudkar Journal of bioenergetics and biomembranes 33, 453-458, 2001 | 522 | 2001 |
| Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein S Dey, M Ramachandra, I Pastan, MM Gottesman, SV Ambudkar Proceedings of the National Academy of Sciences 94 (20), 10594-10599, 1997 | 476 | 1997 |
| Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2 C Dai, AK Tiwari, CP Wu, X Su, SR Wang, D Liu, CR Ashby Jr, Y Huang, ... Cancer research 68 (19), 7905-7914, 2008 | 438 | 2008 |
| Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells S Anuchapreeda, P Leechanachai, MM Smith, SV Ambudkar, P Limtrakul Biochemical pharmacology 64 (4), 573-582, 2002 | 403 | 2002 |
| Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters Y Mi, Y Liang, H Huang, H Zhao, CP Wu, F Wang, L Tao, C Zhang, CL Dai, ... Cancer research 70 (20), 7981-7991, 2010 | 391 | 2010 |
| Silent (synonymous) SNPs: should we care about them? R Hunt, ZE Sauna, SV Ambudkar, MM Gottesman, C Kimchi-Sarfaty Single nucleotide polymorphisms: methods and protocols, 23-39, 2009 | 372 | 2009 |
| Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state M Ramachandra, SV Ambudkar, D Chen, CA Hrycyna, S Dey, ... Biochemistry 37 (14), 5010-5019, 1998 | 363 | 1998 |
| Erlotinib (Tarceva, OSI-774) antagonizes ATP-binding cassette subfamily B member 1 and ATP-binding cassette subfamily G member 2–mediated drug resistance Z Shi, XX Peng, IW Kim, S Shukla, QS Si, RW Robey, SE Bates, T Shen, ... Cancer research 67 (22), 11012-11020, 2007 | 348 | 2007 |
| Prolonged drug selection of breast cancer cells and enrichment of cancer stem cell characteristics AM Calcagno, CD Salcido, JP Gillet, CP Wu, JM Fostel, MD Mumau, ... Journal of the National Cancer Institute 102 (21), 1637-1652, 2010 | 339 | 2010 |
Zuben SaunaPrincipal Investigator, Food and Drug AdministrationDirección de correo verificada de fda.hhs.gov