| From nonpeptide toward noncarbon protease inhibitors: metallacarboranes as specific and potent inhibitors of HIV protease P Cígler, M Kožíšek, P Řezáčová, J Brynda, Z Otwinowski, J Pokorná, ... Proceedings of the National Academy of Sciences 102 (43), 15394-15399, 2005 | 358 | 2005 |
| Link between a novel human γD-crystallin allele and a unique cataract phenotype explained by protein crystallography S Kmoch, J Brynda, B Asfaw, K Bezouška, P Novák, P Řezáčová, ... Human molecular genetics 9 (12), 1779-1786, 2000 | 207 | 2000 |
| A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation J Chmelar, CJ Oliveira, P Rezacova, IMB Francischetti, Z Kovarova, ... Blood, The Journal of the American Society of Hematology 117 (2), 736-744, 2011 | 181 | 2011 |
| Engineering enzyme stability and resistance to an organic cosolvent by modification of residues in the access tunnel T Koudelakova, R Chaloupkova, J Brezovsky, Z Prokop, E Sebestova, ... Angewandte Chemie 125 (7), 2013-2017, 2013 | 170 | 2013 |
| Design of HIV protease inhibitors based on inorganic polyhedral metallacarboranes P Rezacova, J Pokorná, J Brynda, M Kozisek, P Cígler, M Lepsik, ... Journal of medicinal chemistry 52 (22), 7132-7141, 2009 | 163 | 2009 |
| Current and novel inhibitors of HIV protease J Pokorná, L Machala, P Řezáčová, J Konvalinka Viruses 1 (3), 1209-1239, 2009 | 138 | 2009 |
| Inorganic polyhedral metallacarborane inhibitors of HIV protease: a new approach to overcoming antiviral resistance M Kožíšek, P Cígler, M Lepšík, J Fanfrlík, P Řezáčová, J Brynda, ... Journal of medicinal chemistry 51 (15), 4839-4843, 2008 | 119 | 2008 |
| Engineering a de novo transport tunnel J Brezovsky, P Babkova, O Degtjarik, A Fortova, A Gora, I Iermak, ... ACS Catalysis 6 (11), 7597-7610, 2016 | 117 | 2016 |
| Molecular analysis of the HIV-1 resistance development: enzymatic activities, crystal structures, and thermodynamics of nelfinavir-resistant HIV protease mutants M Kožíšek, J Bray, P Řezáčová, K Šašková, J Brynda, J Pokorná, ... Journal of molecular biology 374 (4), 1005-1016, 2007 | 111 | 2007 |
| Carborane-based carbonic anhydrase inhibitors J Brynda, P Mader, V Šícha, M Fábry, K Poncová, M Bakardiev, B Grüner, ... Angew Chem Int Ed Engl 52 (51), 13760-3, 2013 | 103 | 2013 |
| Structural basis for inhibition of cathepsin B drug target from the human blood fluke, Schistosoma mansoni A Jilkova, P Řezáčová, M Lepšík, M Horn, J Váchová, J Fanfrlík, J Brynda, ... Journal of Biological Chemistry 286 (41), 35770-35781, 2011 | 93 | 2011 |
| Crystal structure and functional characterization of an immunomodulatory salivary cystatin from the soft tick Ornithodoros moubata J Salát, GC Paesen, P Řezáčová, M Kotsyfakis, Z Kovářová, M Šanda, ... Biochemical Journal 429 (1), 103-112, 2010 | 91 | 2010 |
| Structure-aided design of novel inhibitors of HIV protease based on a benzodiazepine scaffold J Schimer, P Cígler, J Vesely, K Grantz Šašková, M Lepsik, J Brynda, ... Journal of Medicinal Chemistry 55 (22), 10130-10135, 2012 | 73 | 2012 |
| Thermodynamic and structural analysis of HIV protease resistance to darunavir–analysis of heavily mutated patient‐derived HIV‐1 proteases M Kožíšek, M Lepšík, K Grantz Šašková, J Brynda, J Konvalinka, ... The FEBS journal 281 (7), 1834-1847, 2014 | 70 | 2014 |
| Molecular characterization of clinical isolates of human immunodeficiency virus resistant to the protease inhibitor darunavir KG Šašková, M Kožíšek, P Rˇezácová, J Brynda, T Yashina, ... Journal of virology 83 (17), 8810-8818, 2009 | 68 | 2009 |
| Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif P Tesina, K Čermáková, M Hořejší, K Procházková, M Fábry, S Sharma, ... Nature communications 6 (1), 7968, 2015 | 66 | 2015 |
| Metallacarborane sulfamides: Unconventional, specific, and highly selective inhibitors of carbonic anhydrase IX B Grüner, J Brynda, V Das, V Šícha, J Štěpánková, J Nekvinda, ... Journal of Medicinal Chemistry 62 (21), 9560-9575, 2019 | 64 | 2019 |
| Validation and structural characterization of the LEDGF/p75–MLL interface as a new target for the treatment of MLL-dependent leukemia K Čermáková, P Tesina, J Demeulemeester, S El Ashkar, H Mereau, ... Cancer research 74 (18), 5139-5151, 2014 | 58 | 2014 |
| Ninety-nine is not enough: molecular characterization of inhibitor-resistant human immunodeficiency virus type 1 protease mutants with insertions in the flap region M Kožíšek, KG Šašková, P Řezáčová, J Brynda, ... Journal of virology 82 (12), 5869-5878, 2008 | 58 | 2008 |
| Balancing the stability–activity trade‐off by fine‐tuning dehalogenase access tunnels V Liskova, D Bednar, T Prudnikova, P Rezacova, T Koudelakova, ... ChemCatChem 7 (4), 648-659, 2015 | 56 | 2015 |
