| Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and-independent mechanisms LI Grad, JJ Yerbury, BJ Turner, WC Guest, E Pokrishevsky, MA O’Neill, ... Proceedings of the National Academy of Sciences 111 (9), 3620-3625, 2014 | 480 | 2014 |
| Clinical spectrum of amyotrophic lateral sclerosis (ALS) LI Grad, GA Rouleau, J Ravits, NR Cashman Cold Spring Harbor perspectives in medicine 7 (8), a024117, 2017 | 327 | 2017 |
| Intermolecular transmission of superoxide dismutase 1 misfolding in living cells LI Grad, WC Guest, A Yanai, E Pokrishevsky, MA O'Neill, E Gibbs, ... Proceedings of the National Academy of Sciences 108 (39), 16398-16403, 2011 | 315 | 2011 |
| Aberrant localization of FUS and TDP43 is associated with misfolding of SOD1 in amyotrophic lateral sclerosis E Pokrishevsky, LI Grad, M Yousefi, J Wang, IR Mackenzie, NR Cashman PloS one 7 (4), e35050, 2012 | 222 | 2012 |
| Mitochondrial respiratory chain deficiency inCaenorhabditis elegans results in developmental arrest and increased life span WY Tsang, LC Sayles, LI Grad, DB Pilgrim, BD Lemire Journal of Biological Chemistry 276 (34), 32240-32246, 2001 | 178 | 2001 |
| CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1) G93A ALS mice originate from astrocytes and neurons and carry misfolded SOD1 JM Silverman, D Christy, CC Shyu, KM Moon, S Fernando, Z Gidden, ... Journal of Biological Chemistry 294 (10), 3744-3759, 2019 | 157 | 2019 |
| Competitive organelle-specific adaptors recruit Vps13 to membrane contact sites BDM Bean, SK Dziurdzik, KL Kolehmainen, CMS Fowler, WK Kwong, ... Journal of Cell Biology 217 (10), 3593-3607, 2018 | 149 | 2018 |
| Mitochondrial complex I mutations in Caenorhabditis elegans produce cytochrome c oxidase deficiency, oxidative stress and vitamin-responsive lactic acidosis LI Grad, BD Lemire Human molecular genetics 13 (3), 303-314, 2004 | 145 | 2004 |
| Disease mechanisms in ALS: misfolded SOD1 transferred through exosome-dependent and exosome-independent pathways JM Silverman, SM Fernando, LI Grad, AF Hill, BJ Turner, JJ Yerbury, ... Cellular and molecular neurobiology 36, 377-381, 2016 | 122 | 2016 |
| From molecule to molecule and cell to cell: prion-like mechanisms in amyotrophic lateral sclerosis LI Grad, SM Fernando, NR Cashman Neurobiology of disease 77, 257-265, 2015 | 99 | 2015 |
| TDP-43 or FUS-induced misfolded human wild-type SOD1 can propagate intercellularly in a prion-like fashion E Pokrishevsky, LI Grad, NR Cashman Scientific reports 6 (1), 22155, 2016 | 91 | 2016 |
| Prion-like activity of Cu/Zn superoxide dismutase: implications for amyotrophic lateral sclerosis LI Grad, NR Cashman Prion 8 (1), 33-41, 2014 | 82 | 2014 |
| Generalization of the prion hypothesis to other neurodegenerative diseases: an imperfect fit WC Guest, JM Silverman, E Pokrishevsky, MA O'Neill, LI Grad, ... Journal of Toxicology and Environmental Health, Part A 74 (22-24), 1433-1459, 2011 | 81 | 2011 |
| Exosome-dependent and independent mechanisms are involved in prion-like transmission of propagated Cu/Zn superoxide dismutase misfolding LI Grad, E Pokrishevsky, JM Silverman, NR Cashman Prion 8 (5), 331-335, 2014 | 75 | 2014 |
| Riboflavin enhances the assembly of mitochondrial cytochrome c oxidase in C. elegans NADH-ubiquinone oxidoreductase mutants LI Grad, BD Lemire Biochimica Et Biophysica Acta (BBA)-Bioenergetics 1757 (2), 115-122, 2006 | 61 | 2006 |
| Isolation and Functional Analysis of Mitochondria From the Nematode Caenorhabditis elegans LI Grad, LC Sayles, BD Lemire Mitochondria: practical protocols, 51-66, 2007 | 50 | 2007 |
| Introduction of an additional pathway for lactate oxidation in the treatment of lactic acidosis and mitochondrial dysfunction in Caenorhabditis elegans LI Grad, LC Sayles, BD Lemire Proceedings of the National Academy of Sciences 102 (51), 18367-18372, 2005 | 50 | 2005 |
| Locally released retinoic acid repatterns the first branchial arch cartilages in vivo MR Plant, MP MacDonald, LI Grad, SJ Ritchie, JM Richman Developmental biology 222 (1), 12-26, 2000 | 40 | 2000 |
| Inactivation of the Neurospora crassa mitochondrial outer membrane protein TOM70 by repeat-induced point mutation (RIP) causes defects in mitochondrial protein import and … LI Grad, AT Descheneau, W Neupert, R Lill, FE Nargang Current genetics 36, 137-146, 1999 | 34 | 1999 |
| Intercellular prion-like conversion and transmission of Cu/Zn superoxide dismutase (SOD1) in cell culture LI Grad, E Pokrishevsky, NR Cashman Prions: Methods and Protocols, 357-367, 2017 | 8 | 2017 |
Neil CashmanUniversity of British ColumbiaDirección de correo verificada de vch.ca