| A reference map of potential determinants for the human serum metabolome N Bar, T Korem, O Weissbrod, D Zeevi, D Rothschild, S Leviatan, ... Nature 588 (7836), 135-140, 2020 | 371 | 2020 |
| Natural thermal adaptation increases heat shock protein levels and decreases oxidative stress NKJ Oksala, FG Ekmekçi, E Özsoy, Ş Kirankaya, T Kokkola, G Emecen, ... Redox biology 3, 25-28, 2014 | 136 | 2014 |
| Chroman-4-one-and chromone-based sirtuin 2 inhibitors with antiproliferative properties in cancer cells T Seifert, M Malo, T Kokkola, K Engen, M Friden-Saxin, EAA Wallén, ... Journal of medicinal chemistry 57 (23), 9870-9888, 2014 | 119 | 2014 |
| An inter-laboratory validation of methods of lipid peroxidation measurement in UVA-treated human plasma samples N Breusing, T Grune, L Andrisic, M Atalay, G Bartosz, F Biasi, S Borovic, ... Free radical research 44 (10), 1203-1215, 2010 | 89 | 2010 |
| A rhodopsin-based model for melatonin recognition at its G protein-coupled receptor C Navajas, T Kokkola, A Poso, N Honka, J Gynther, JT Laitinen European journal of pharmacology 304 (1-3), 173-183, 1996 | 84 | 1996 |
| Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study A Wesolowska-Andersen, CA Brorsson, R Bizzotto, A Mari, A Tura, ... Cell Reports Medicine 3 (1), 2022 | 80 | 2022 |
| Mutagenesis of human Mel1amelatonin Receptor expressed in yeast reveals domains important for receptor function T Kokkola, MA Watson, J White, S Dowell, SM Foord, JT Laitinen Biochemical and biophysical research communications 249 (2), 531-536, 1998 | 78 | 1998 |
| Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts N Atabaki-Pasdar, M Ohlsson, A Viñuela, F Frau, H Pomares-Millan, ... PLoS medicine 17 (6), e1003149, 2020 | 75 | 2020 |
| Melatonin receptor genes T Kokkola, JT Laitinen Annals of medicine 30 (1), 88-94, 1998 | 69 | 1998 |
| Studying SIRT6 regulation using H3K56 based substrate and small molecules P Kokkonen, M Rahnasto-Rilla, P Mellini, E Jarho, M Lahtela-Kakkonen, ... European Journal of Pharmaceutical Sciences 63, 71-76, 2014 | 63 | 2014 |
| S-nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner T Kokkola, JR Savinainen, KS Mönkkönen, MD Retamal, JT Laitinen BMC cell biology 6, 1-17, 2005 | 61 | 2005 |
| Identification of WIN55212‐3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor JR Savinainen, T Kokkola, OMH Salo, A Poso, T Järvinen, JT Laitinen British journal of pharmacology 145 (5), 636-645, 2005 | 60 | 2005 |
| Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models RL Allesøe, AT Lundgaard, R Hernández Medina, A Aguayo-Orozco, ... Nature biotechnology 41 (3), 399-408, 2023 | 59 | 2023 |
| Pharmacogenomics of GLP-1 receptor agonists: a genome-wide analysis of observational data and large randomised controlled trials AY Dawed, A Mari, A Brown, TJ McDonald, L Li, S Wang, MG Hong, ... The Lancet Diabetes & Endocrinology 11 (1), 33-41, 2023 | 56 | 2023 |
| Simvastatin impairs insulin secretion by multiple mechanisms in MIN6 cells N Yaluri, S Modi, M López Rodríguez, A Stančáková, J Kuusisto, ... PLoS One 10 (11), e0142902, 2015 | 53 | 2015 |
| GFAP as a biomarker in frontotemporal dementia and primary psychiatric disorders: diagnostic and prognostic performance K Katisko, A Cajanus, N Huber, O Jääskeläinen, T Kokkola, V Kärkkäinen, ... Journal of Neurology, Neurosurgery & Psychiatry 92 (12), 1305-1312, 2021 | 50 | 2021 |
| N‐acylethanolamines bind to SIRT6 M Rahnasto‐Rilla, T Kokkola, E Jarho, M Lahtela‐Kakkonen, R Moaddel Chembiochem 17 (1), 77-81, 2016 | 46 | 2016 |
| Important amino acids for the function of the human MT1 melatonin receptor T Kokkola, SM Foord, MA Watson, O Vakkuri, JT Laitinen Biochemical pharmacology 65 (9), 1463-1471, 2003 | 45 | 2003 |
| Simvastatin induces insulin resistance in L6 skeletal muscle myotubes by suppressing insulin signaling, GLUT4 expression and GSK-3β phosphorylation N Yaluri, S Modi, T Kokkola Biochemical and biophysical research communications 480 (2), 194-200, 2016 | 44 | 2016 |
| Screen of pseudopeptidic inhibitors of human sirtuins 1–3: two lead compounds with antiproliferative effects in cancer cells P Mellini, T Kokkola, T Suuronen, HS Salo, L Tolvanen, A Mai, ... Journal of Medicinal Chemistry 56 (17), 6681-6695, 2013 | 44 | 2013 |
