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Ekram Ahmed Chowdhury, Ph.D.
Ekram Ahmed Chowdhury, Ph.D.
Senior Clinical Pharmacologist, AbbVie
Dirección de correo verificada de abbvie.com
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In vitro modeling of the neurovascular unit: advances in the field
A Bhalerao, F Sivandzade, SR Archie, EA Chowdhury, B Noorani, ...
Fluids and Barriers of the CNS 17 (1), 1-20, 2020
1332020
Current progress and limitations of AAV mediated delivery of protein therapeutic genes and the importance of developing quantitative pharmacokinetic/pharmacodynamic (PK/PD) models
EA Chowdhury, G Meno-Tetang, HY Chang, S Wu, HW Huang, T Jamier, ...
Advanced drug delivery reviews 170, 214-237, 2021
612021
Brain energy metabolism in ischemic stroke: effects of smoking and diabetes
AE Sifat, S Nozohouri, SR Archie, EA Chowdhury, TJ Abbruscato
International Journal of Molecular Sciences 23 (15), 8512, 2022
422022
Understanding the brain uptake and permeability of small molecules through the BBB: A technical overview
EA Chowdhury, B Noorani, F Alqahtani, A Bhalerao, S Raut, ...
Journal of Cerebral Blood Flow & Metabolism, 0271678X20985946, 2021
412021
Peptidase neurolysin functions to preserve the brain after ischemic stroke in male mice
S Jayaraman, A Al Shoyaib, J Kocot, H Villalba, FF Alamri, M Rashid, ...
Journal of neurochemistry 153 (1), 120-137, 2020
292020
LC–MS/MS-based in vitro and in vivo investigation of blood–brain barrier integrity by simultaneous quantitation of mannitol and sucrose
B Noorani, EA Chowdhury, F Alqahtani, Y Ahn, D Patel, A Al-Ahmad, ...
Fluids and Barriers of the CNS 17, 1-15, 2020
282020
Isoflurane increases cell membrane fluidity significantly at clinical concentrations
J Patel, EA Chowdhury, B Noorani, U Bickel, J Huang
Biochimica et Biophysica Acta (BBA)-Biomembranes 1862 (2), 183140, 2020
262020
Evaluation of [14C] and [13C] Sucrose as Blood–Brain Barrier Permeability Markers
MK Miah, EA Chowdhury, U Bickel, R Mehvar
Journal of pharmaceutical sciences 106 (6), 1659-1669, 2017
252017
Brain uptake of [13C] and [14C] sucrose quantified by microdialysis and whole tissue analysis in mice
F Alqahtani, EA Chowdhury, R Bhattacharya, B Noorani, R Mehvar, ...
Drug Metabolism and Disposition 46 (11), 1514-1518, 2018
162018
Simultaneous UPLC–MS/MS analysis of two stable isotope labeled versions of sucrose in mouse plasma and brain samples as markers of blood-brain barrier permeability and brain …
EA Chowdhury, F Alqahtani, R Bhattacharya, R Mehvar, U Bickel
Journal of Chromatography B 1073, 19-26, 2018
152018
Enrichment of the erythrocyte miR-451a in brain extracellular vesicles following impairment of the blood-brain barrier
NN Koopaei, EA Chowdhury, J Jiang, B Noorani, L da Silva, G Bulut, ...
Neuroscience Letters 751, 135829, 2021
132021
Effects of volatile anesthetics versus ketamine on blood-brain barrier permeability via lipid-mediated alterations of endothelial cell membranes
B Noorani, EA Chowdhury, F Alqahtani, Y Ahn, E Nozohouri, S Zoubi, ...
The Journal of Pharmacology and Experimental Therapeutics 385 (2), 135-145, 2023
112023
Assessment of AAV9 distribution and transduction in rats after administration through Intrastriatal, Intracisterna magna and Lumbar Intrathecal routes
J Chandran, EA Chowdhury, M Perkinton, T Jamier, D Sutton, S Wu, ...
Gene Therapy 30 (1), 132-141, 2023
112023
Towards a translational physiologically-based pharmacokinetic (PBPK) model for receptor-mediated transcytosis of anti-transferrin receptor monoclonal antibodies in the central …
HY Chang, S Wu, EA Chowdhury, DK Shah
Journal of Pharmacokinetics and Pharmacodynamics 49 (3), 337-362, 2022
92022
LC-MS/MS-based in vitro and in vivo investigation of blood-brain barrier integrity by simultaneous quantitation of mannitol and sucrose. Fluids Barriers CNS 2020; 17 (1): 1-15
B Noorani, EA Chowdhury, F Alqahtani, Y Ahn, D Patel, A Al-Ahmad, ...
8
Advanced microfluidic vascularized tissues as platform for the study of human diseases and drug development
B Noorani, L Cucullo, Y Ahn, H Kadry, A Bhalerao, S Raut, E Nozohouri, ...
Current Neuropharmacology 21 (3), 599-620, 2023
52023
Pharmacokinetics of AAV9 mediated trastuzumab expression in rat brain following systemic and local administration
EA Chowdhury, M Ahuja, S Wu, S Liu, HW Huang, M Kumar, KS Sunkara, ...
Journal of Pharmaceutical Sciences 113 (1), 131-140, 2024
42024
Whole-body disposition and physiologically based pharmacokinetic modeling of adeno-associated viruses and the transgene product
S Liu, EA Chowdhury, V Xu, A Jerez, L Mahmood, BQ Ly, HK Le, ...
Journal of Pharmaceutical Sciences 113 (1), 141-157, 2024
32024
Role of Glucosamine Sulphate, Chrondoitin Sulphate and Vitamin C in the management of pain in Osteoarthritis
RK Saha, EA Chowdhury, S Tanzin, P Chakrabartey, RK Saha, P Roy, ...
Bull. Env. Pharmacol. Life Sci 4 (6), 40-48, 2015
22015
A Semi-Physiological Three-Compartment Model Describes Brain Uptake Clearance and Efflux of Sucrose and Mannitol after IV Injection in Awake Mice
B Noorani, EA Chowdhury, F Alqahtani, MS Sajib, Y Ahn, E Nozohouri, ...
Pharmaceutical research 39 (2), 251-261, 2022
12022
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