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Vedagopuram Sreekanth
Vedagopuram Sreekanth
Research Scientist: Broad Institute of MIT and Harvard
Dirección de correo verificada de mit.edu - Página principal
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Injectable small molecule hydrogel as a potential nanocarrier for localized and sustained in vivo delivery of doxorubicin
M Singh, S Kundu, V Sreekanth, RK Motiani, S Sengupta, A Srivastava, ...
Nanoscale 6, 12849-12855, 2014
882014
Transcription regulation of CDKN1A (p21/CIP1/WAF1) by TRF2 is epigenetically controlled through the REST repressor complex
T Hussain, D Saha, G Purohit, A Kar, AK Mukherjee, S Sharma, ...
Scientific reports 7 (1), 1-13, 2017
632017
Design, Synthesis, and Mechanistic Investigations of Bile acid-Tamoxifen Conjugates for Breast Cancer Therapy
V Sreekanth, S Bansal, RK Motiani, S Kundu, SK Muppu, TD Majumdar, ...
Bioconjugate chemistry 24 (9), 1468–1484, 2013
592013
CRISPR-based therapeutics: current challenges and future applications
AEM Modell, D Lim, T Nguyen, V Sreekanth, A Choudhary
Trends in Pharmacological Sciences 43 (2), 151-161, 2022
582022
Engineering designer beta cells with a CRISPR-Cas9 conjugation platform
D Lim, V Sreekanth, KJ Cox, BK Law, BK Wagner, JM Karp, A Choudhary
Nature Communications 11, 4043, 2020
492020
Proteolysis-targeting chimeras with reduced off-targets
TM Nguyen, V Sreekanth, A Deb, P Kokkonda, PK Tiwari, KA Donovan, ...
Nature Chemistry 16 (2), 218-228, 2024
372024
Design, regioselective synthesis and cytotoxic evaluation of 2-aminoimidazole–quinoline hybrids against cancer and primary endothelial cells
K Singh, V Verma, K Yadav, V Sreekanth, D Kumar, A Bajaj, V Kumar
European journal of medicinal chemistry 87, 150-158, 2014
362014
Synthesis, structure–activity relationship, and mechanistic investigation of lithocholic acid amphiphiles for colon cancer therapy
M Singh, S Bansal, S Kundu, P Bhargava, A Singh, RK Motiani, R Shyam, ...
MedChemComm 6, 192-201, 2015
312015
Bile acid amphiphiles with tunable head groups as highly selective antitubercular agents
S Bansal, M Singh, S Kidwai, P Bhargava, A Singh, V Sreekanth, R Singh, ...
MedChemComm 5, 1761-1768, 2014
312014
Recent Advances in Engineering of Lipid-Drug Conjugates for Cancer Therapy
V Sreekanth, A Bajaj
ACS Biomater. Sci. Eng. 5 (9), 4148-4166, 2019
282019
A 3D culture platform enables development of zinc-binding prodrugs for targeted proliferation of β cells
ACJMK Kisuk Yang, Miseon Lee, Peter Anthony Jones, Sophie S. Liu, Angela ...
Science Advances 6, eabc3207, 2020
252020
Tethering of Chemotherapeutic Drug/Imaging Agent to Bile Acid-Phospholipid Increases the Efficacy and Bioavailability with Reduced Hepatotoxicity
AB V. Sreekanth, N. Medatwal, S. Kumar, S. Pal, V. Malyla, A. Kar, P ...
Bioconjugate Chem. 28 (12), 2942-2953, 2017
212017
FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity
N Wieder, JM Coraor Fried, C Kim, EH Sidhom, MR Brown, JL Marshall, ...
Cell Metabolism 35 (5), 887-905.e11, 2023
202023
Continuous evolution of compact protein degradation tags regulated by selective molecular glues
DRL JAM Mercer, SJ DeCarlo, SSR Burman, V Sreekanth, AT Nelson, M Hunkeler ...
Science 383 (6688), eadk4422, 2024
192024
Chemogenetic System Demonstrates That Cas9 Longevity Impacts Genome Editing Outcomes
AC Vedagopuram Sreekanth, Qingxuan Zhou, Praveen Kokkonda, Heysol C ...
ACS Central Science 6 (12), 2228–2237, 2020
192020
Nature of the Charged Head Group Determines the Fusogenic Potential and Membrane Properties of Lithocholic Acid Phospholipids
P Bhargava, M Singh, V Sreekanth, A Bajaj
The Journal of Physical Chemistry B 118 (31), 9341-9348, 2014
192014
Fluorescence (fluidity/hydration) and calorimetric studies of interactions of bile acid–drug conjugates with model membranes
V Sreekanth, A Bajaj
The Journal of Physical Chemistry B 117 (7), 2123-2133, 2013
192013
Number of Free Hydroxyl Groups on Bile Acid Phospholipids Determines the Fluidity and Hydration of Model Membranes
V Sreekanth, A Bajaj
The Journal of Physical Chemistry B 117 (40), 12135–12144, 2013
182013
Bile Acid Tethered Docetaxel‐based Nanomicelles Mitigate Tumor Progression through Epigenetic Changes.
V Sreekanth, A Kar, S Kumar, S Pal, P Yadav, Y Sharma, V Komalla, ...
Angewandte Chemie International Edition 60 (10), 5394-5399, 2021
162021
Nature of the Charged Head Group Dictates the Anticancer Potential of Lithocholic Acid-Tamoxifen Conjugates For Breast Cancer Therapy
K Yadav, P Bhargava, S Bansal, M Singh, S Gupta, G Sandhu, S Kumar, ...
MedChemComm. 6, 778-787, 2015
152015
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