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Benjamin Nacev
Benjamin Nacev
University of Pittsburgh School of Medicine
Dirección de correo verificada de upmc.edu - Página principal
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The expanding landscape of ‘oncohistone’mutations in human cancers
BA Nacev, L Feng, JD Bagert, AE Lemiesz, JJ Gao, AA Soshnev, ...
Nature 567 (7749), 473-478, 2019
3602019
Protein N-Terminal Processing: Substrate Specificity of Escherichia coli and Human Methionine Aminopeptidases
Q Xiao, F Zhang, BA Nacev, JO Liu, D Pei
Biochemistry 49 (26), 5588-5599, 2010
2172010
The epigenomics of sarcoma
BA Nacev, KB Jones, AM Intlekofer, JSE Yu, CD Allis, WD Tap, M Ladanyi, ...
Nature Reviews Cancer 20 (10), 608-623, 2020
1912020
The antifungal drug itraconazole inhibits vascular endothelial growth factor receptor 2 (VEGFR2) glycosylation, trafficking, and signaling in endothelial cells
BA Nacev, P Grassi, A Dell, SM Haslam, JO Liu
Journal of Biological Chemistry 286 (51), 44045-44056, 2011
1492011
Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets
BA Nacev, F Sanchez-Vega, SA Smith, CR Antonescu, E Rosenbaum, ...
Nature Communications 13 (1), 3405, 2022
1352022
Effect of nitroxoline on angiogenesis and growth of human bladder cancer
JS Shim, Y Matsui, S Bhat, BA Nacev, J Xu, HC Bhang, S Dhara, KC Han, ...
Journal of the National Cancer Institute 102 (24), 1855-1873, 2010
1302010
Mechanisms of aneuploidy in thyroid cancer cell lines and tissues: evidence for mitotic checkpoint dysfunction without mutations in BUB1 and BUBR1
B Ouyang, JA Knauf, K Ain, B Nacev, JA Fagin
Clinical endocrinology 56 (3), 341-350, 2002
802002
Simultaneous targeting of NPC1 and VDAC1 by itraconazole leads to synergistic inhibition of mTOR signaling and angiogenesis
SA Head, WQ Shi, EJ Yang, BA Nacev, SY Hong, KK Pasunooti, RJ Li, ...
ACS chemical biology 12 (1), 174-182, 2017
772017
Itraconazole side chain analogues: structure–activity relationship studies for inhibition of endothelial cell proliferation, vascular endothelial growth factor receptor 2 …
W Shi, BA Nacev, BT Aftab, S Head, CM Rudin, JO Liu
Journal of medicinal chemistry 54 (20), 7363-7374, 2011
752011
Oncohistone mutations enhance chromatin remodeling and alter cell fates
JD Bagert, MM Mitchener, AL Patriotis, BE Dul, F Wojcik, BA Nacev, ...
Nature chemical biology 17 (4), 403-411, 2021
742021
High-throughput screen identifies novel inhibitors of cancer biomarker α-methylacyl coenzyme A racemase (AMACR/P504S)
BAP Wilson, H Wang, BA Nacev, RC Mease, JO Liu, MG Pomper, ...
Molecular cancer therapeutics 10 (5), 825-838, 2011
642011
Impact of absolute stereochemistry on the antiangiogenic and antifungal activities of itraconazole
W Shi, BA Nacev, S Bhat, JO Liu
ACS medicinal chemistry letters 1 (4), 155-159, 2010
552010
Synergistic inhibition of endothelial cell proliferation, tube formation, and sprouting by cyclosporin A and itraconazole
BA Nacev, JO Liu
PloS one 6 (9), e24793, 2011
412011
Pilot study of bempegaldesleukin in combination with nivolumab in patients with metastatic sarcoma
SP D’Angelo, AL Richards, AP Conley, HJ Woo, MA Dickson, M Gounder, ...
Nature communications 13 (1), 3477, 2022
372022
A phase II study of epacadostat and pembrolizumab in patients with advanced sarcoma
CM Kelly, LX Qin, KA Whiting, AL Richards, V Avutu, JE Chan, P Chi, ...
Clinical Cancer Research 29 (11), 2043-2051, 2023
36*2023
Clinical, genomic, and transcriptomic correlates of response to immune checkpoint blockade-based therapy in a cohort of patients with angiosarcoma treated at a single center
E Rosenbaum, CR Antonescu, S Smith, M Bradic, D Kashani, ...
Journal for immunotherapy of cancer 10 (4), 2022
362022
Clinical Outcome of Leiomyosarcomas With Somatic Alteration in Homologous Recombination Pathway Genes
E Rosenbaum, P Jonsson, K Seier, LX Qin, P Chi, M Dickson, M Gounder, ...
JCO precision oncology 4, 1350-1360, 2020
322020
A calcineurin-independent mechanism of angiogenesis inhibition by a nonimmunosuppressive cyclosporin A analog
BA Nacev, WK Low, Z Huang, TT Su, Z Su, H Alkuraya, D Kasuga, W Sun, ...
Journal of Pharmacology and Experimental Therapeutics 338 (2), 466-475, 2011
262011
Phase II trial of imatinib plus binimetinib in patients with treatment-naive advanced gastrointestinal stromal tumor
P Chi, LX Qin, B Nguyen, CM Kelly, SP D'Angelo, MA Dickson, ...
Journal of Clinical Oncology 40 (9), 997-1008, 2022
212022
Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells
F Zhang, S Bhat, SB Gabelli, X Chen, MS Miller, BA Nacev, YL Cheng, ...
Journal of medicinal chemistry 56 (10), 3996-4016, 2013
212013
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Artículos 1–20