| Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis CJ Sinal, M Tohkin, M Miyata, JM Ward, G Lambert, FJ Gonzalez Cell 102 (6), 731-744, 2000 | 2081 | 2000 |
| HLA-B locus in Japanese patients with anti-epileptics and allopurinol-related Stevens–Johnson syndrome and toxic epidermal necrolysis N Kaniwa, Y Saito, M Aihara, K Matsunaga, M Tohkin, K Kurose, ... Pharmacogenomics 9 (11), 1617-1622, 2008 | 512 | 2008 |
| Targeted disruption of soluble epoxide hydrolase reveals a role in blood pressure regulation CJ Sinal, M Miyata, M Tohkin, K Nagata, JR Bend, FJ Gonzalez Journal of Biological Chemistry 275 (51), 40504-40510, 2000 | 432 | 2000 |
| Mechanism of antihepatotoxic activity of glycyrrhizin, I: effect on free radical generation and lipid peroxidation Y Kiso, M Tohkin, H Hikino, M Hattori, T Sakamoto, T Namba Planta medica 50 (04), 298-302, 1984 | 315 | 1984 |
| HLA‐B*1511 is a risk factor for carbamazepine‐induced Stevens‐Johnson syndrome and toxic epidermal necrolysis in Japanese patients N Kaniwa, Y Saito, M Aihara, K Matsunaga, M Tohkin, K Kurose, H Furuya, ... Epilepsia 51 (12), 2461-2465, 2010 | 276 | 2010 |
| Racial variability in haplotype frequencies of UGT1A1 and glucuronidation activity of a novel single nucleotide polymorphism 686C> T (P229L) found in an African-American N Kaniwa, K Kurose, H Jinno, T Tanaka-Kagawa, Y Saito, M Saeki, ... Drug Metabolism and Disposition 33 (3), 458-465, 2005 | 214 | 2005 |
| A whole-genome association study of major determinants for allopurinol-related Stevens–Johnson syndrome and toxic epidermal necrolysis in Japanese patients M Tohkin, N Kaniwa, Y Saito, E Sugiyama, K Kurose, J Nishikawa, ... The pharmacogenomics journal 13 (1), 60-69, 2013 | 206 | 2013 |
| Low-dose dioxins alter gene expression related to cholesterol biosynthesis, lipogenesis, and glucose metabolism through the aryl hydrocarbon receptor-mediated pathway in mouse … S Sato, H Shirakawa, S Tomita, Y Ohsaki, K Haketa, O Tooi, N Santo, ... Toxicology and Applied Pharmacology 229 (1), 10-19, 2008 | 177 | 2008 |
| Assay method for antihepatotoxic activity using carbon tetrachloride induced cytotoxicity in primary cultured hepatocytes Y Kiso, M Tohkin, H Hikino Planta Medica 49 (12), 222-225, 1983 | 150 | 1983 |
| Assay method for antihepatotoxic activity using galactosamine-induced cytotoxicity in primary-cultured hepatocytes Y Kiso, M Tohkin, H Hikino Journal of natural products 46 (6), 841-847, 1983 | 119 | 1983 |
| Effect of CYP2C9 genetic polymorphisms on the efficacy and pharmacokinetics of glimepiride in subjects with type 2 diabetes K Suzuki, T Yanagawa, T Shibasaki, N Kaniwa, R Hasegawa, M Tohkin Diabetes research and clinical practice 72 (2), 148-154, 2006 | 110 | 2006 |
| Genetic variations and haplotypes of CYP2C19 in a Japanese population H Fukushima-Uesaka, Y Saito, K Maekawa, S Ozawa, R Hasegawa, ... Drug metabolism and pharmacokinetics 20 (4), 300-307, 2005 | 107 | 2005 |
| Four novel defective alleles and comprehensive haplotype analysis of CYP2C9 in Japanese K Maekawa, H Fukushima-Uesaka, M Tohkin, R Hasegawa, H Kajio, ... Pharmacogenetics and genomics 16 (7), 497-514, 2006 | 103 | 2006 |
| Chemotactic peptide receptor-supported ADP-ribosylation of a pertussis toxin substrate GTP-binding protein by cholera toxin in neutrophil-type HL-60 cells T Iiri, M Tohkin, N Morishima, Y Ohoka, M Ui, T Katada Journal of Biological Chemistry 264 (35), 21394-21400, 1989 | 87 | 1989 |
| Antihepatotoxic principles of Atractylodes rhizomes Y Kiso, M Tohkin, H Hikino Journal of natural products 46 (5), 651-654, 1983 | 87 | 1983 |
| Mechanism of antihepatotoxic activity of wuweizisu C and gomisin A Y Kiso, M Tohkin, H Hikino, Y Ikeya, H Taguchi Planta medica 51 (04), 331-334, 1985 | 86 | 1985 |
| Identification of the functional vitamin D response elements in the human MDR1 gene M Saeki, K Kurose, M Tohkin, R Hasegawa Biochemical pharmacology 76 (4), 531-542, 2008 | 85 | 2008 |
| Pancreatic-type phospholipase A2 stimulates prostaglandin synthesis in mouse osteoblastic cells (MC3T3-E1) via a specific binding site. M Tohkin, J Kishino, J Ishizaki, H Arita Journal of Biological Chemistry 268 (4), 2865-2871, 1993 | 80 | 1993 |
| Specific HLA types are associated with antiepileptic drug-induced Stevens–Johnson syndrome and toxic epidermal necrolysis in Japanese subjects N Kaniwa, E Sugiyama, Y Saito, K Kurose, K Maekawa, R Hasegawa, ... Pharmacogenomics 14 (15), 1821-1831, 2013 | 78 | 2013 |
| Androgens directly stimulate mineralization and increase androgen receptors in human osteoblast-like osteosarcoma cells M Takeuchi, H Kakushi, M Tohkin Biochemical and biophysical research communications 204 (2), 905-911, 1994 | 78 | 1994 |
