| Ethoxy-, pentoxy-and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450 MD Burke, S Thompson, CR Elcombe, J Halpert, T Haaparanta, RT Mayer Biochemical pharmacology 34 (18), 3337-3345, 1985 | 1617 | 1985 |
| The genetic determinants of the CYP3A5 polymorphism E Hustert, M Haberl, O Burk, R Wolbold, YQ He, K Klein, AC Nuessler, ... Pharmacogenetics and Genomics 11 (9), 773-779, 2001 | 858 | 2001 |
| An open conformation of mammalian cytochrome P450 2B4 at 1.6-Å resolution EE Scott, YA He, MR Wester, MA White, CC Chin, JR Halpert, EF Johnson, ... Proceedings of the National Academy of Sciences 100 (23), 13196-13201, 2003 | 447 | 2003 |
| Structure of mammalian cytochrome P450 2B4 complexed with 4-(4-chlorophenyl) imidazole at 1.9-Å resolution: insight into the range of P450 conformations and the coordination of … EE Scott, MA White, YA He, EF Johnson, CD Stout, JR Halpert Journal of Biological Chemistry 279 (26), 27294-27301, 2004 | 362 | 2004 |
| Identification and functional characterization of eight CYP3A4 protein variants R Eiselt, TL Domanski, A Zibat, R Mueller, E Presecan-Siedel, E Hustert, ... Pharmacogenetics and Genomics 11 (5), 447-458, 2001 | 347 | 2001 |
| cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450 TL Domanski, C Finta, JR Halpert, PG Zaphiropoulos Molecular Pharmacology 59 (2), 386-392, 2001 | 297 | 2001 |
| Analysis of human cytochrome P450 3A4 cooperativity: construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kinetics GR Harlow, JR Halpert Proceedings of the National Academy of Sciences 95 (12), 6636-6641, 1998 | 297 | 1998 |
| Selective inhibitors of cytochromes P450 JR Halpert, FP Guengerich, JR Bend, MA Correia Toxicology and applied pharmacology 125 (2), 163-175, 1994 | 288 | 1994 |
| Toxicology of thiono-sulfur compounds. RA Neal, J Halpert Annual review of pharmacology and toxicology 22, 321-339, 1982 | 227 | 1982 |
| Amino acid sequence of a presynaptic neurotoxin from the venom of Notechis scutatus scutatus (Australian tiger snake). J Halpert, D Eaker Journal of Biological Chemistry 250 (17), 6990-6997, 1975 | 223 | 1975 |
| Midazolam oxidation by cytochrome P450 3A4 and active-site mutants: an evaluation of multiple binding sites and of the metabolic pathway that leads to enzyme inactivation KK Khan, YQ He, TL Domanski, JR Halpert Molecular pharmacology 61 (3), 495-506, 2002 | 206 | 2002 |
| Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction Y Zhao, MA White, BK Muralidhara, L Sun, JR Halpert, CD Stout Journal of Biological Chemistry 281 (9), 5973-5981, 2006 | 190 | 2006 |
| Alanine-scanning mutagenesis of a putative substrate recognition site in human cytochrome P450 3A4: role of residues 210 and 211 in flavonoid activation and substrate specificity GR Harlow, JR Halpert Journal of Biological Chemistry 272 (9), 5396-5402, 1997 | 190 | 1997 |
| Analysis of mammalian cytochrome P450 structure and function by site-directed mutagenesis TL Domanski, JR Halpert Current drug metabolism 2 (2), 117-137, 2001 | 179 | 2001 |
| Molecular modeling of cytochrome P450 3A4 GD Szklarz, JR Halpert Journal of computer-aided molecular design 11, 265-272, 1997 | 174 | 1997 |
| Phenylalanine and tryptophan scanning mutagenesis of CYP3A4 substrate recognition site residues and effect on substrate oxidation and cooperativity TL Domanski, YA He, KK Khan, F Roussel, Q Wang, JR Halpert Biochemistry 40 (34), 10150-10160, 2001 | 173 | 2001 |
| Analysis of four residues within substrate recognition site 4 of human cytochrome P450 3A4: role in steroid hydroxylase activity and α-naphthoflavone stimulation TL Domanski, J Liu, GR Harlow, JR Halpert Archives of biochemistry and biophysics 350 (2), 223-232, 1998 | 165 | 1998 |
| The role of phospholipase activity in the action of a presynaptic neurotoxin from the venom of Notechis scutatus scutatus (Australian tiger snake) J Halpert, D Eaker, E Karlsson Febs Letters 61 (1), 72-76, 1976 | 162 | 1976 |
| Structural Basis of Selective Cytochrome P 450 Inhibition JR Halpert Annual Review of Pharmacology and Toxicology 35 (1), 29-53, 1995 | 159 | 1995 |
| A truncation of 2B subfamily cytochromes P450 yields increased expression levels, increased solubility, and decreased aggregation while retaining function EE Scott, M Spatzenegger, JR Halpert Archives of Biochemistry and Biophysics 395 (1), 57-68, 2001 | 157 | 2001 |
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