| Proteasome dysfunction in Drosophila signals to an Nrf2‐dependent regulatory circuit aiming to restore proteostasis and prevent premature aging EN Tsakiri, GP Sykiotis, IS Papassideri, E Terpos, MA Dimopoulos, ... Aging cell 12 (5), 802-813, 2013 | 113 | 2013 |
| Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress EN Tsakiri, GP Sykiotis, IS Papassideri, VG Gorgoulis, D Bohmann, ... The FASEB Journal 27 (6), 2407, 2013 | 92 | 2013 |
| The amazing ubiquitin-proteasome system: structural components and implication in aging EN Tsakiri, IP Trougakos International review of cell and molecular biology 314, 171-237, 2015 | 78 | 2015 |
| Diet-derived advanced glycation end products or lipofuscin disrupts proteostasis and reduces life span in Drosophila melanogaster EN Tsakiri, KK Iliaki, A Höhn, S Grimm, IS Papassideri, T Grune, ... Free Radical Biology and Medicine 65, 1155-1163, 2013 | 72 | 2013 |
| Non-enzymatic post-translational protein modifications and proteostasis network deregulation in carcinogenesis IP Trougakos, F Sesti, E Tsakiri, VG Gorgoulis Journal of Proteomics 92, 274-298, 2013 | 59 | 2013 |
| Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation EN Tsakiri, S Gumeni, KK Iliaki, D Benaki, K Vougas, GP Sykiotis, ... Aging cell 18 (1), e12845, 2019 | 58 | 2019 |
| Comparison survey of EVOO polyphenols and exploration of healthy aging-promoting properties of oleocanthal and oleacein T Nikou, V Liaki, P Stathopoulos, AD Sklirou, EN Tsakiri, T Jakschitz, ... Food and Chemical Toxicology 125, 403-412, 2019 | 54 | 2019 |
| Selective cytotoxicity of the herbal substance acteoside against tumor cells and its mechanistic insights C Cheimonidi, P Samara, P Polychronopoulos, EN Tsakiri, T Nikou, ... Redox Biology 16, 169-178, 2018 | 52 | 2018 |
| Proteasome dysfunction induces excessive proteome instability and loss of mitostasis that can be mitigated by enhancing mitochondrial fusion or autophagy EN Tsakiri, S Gumeni, K Vougas, D Pendin, I Papassideri, A Daga, ... Autophagy 15 (10), 1757-1773, 2019 | 42 | 2019 |
| Isolation of natural products with anti-ageing activity from the fruits of Platanus orientalis S Chatzigeorgiou, QD Thai, J Tchoumtchoua, K Tallas, EN Tsakiri, ... Phytomedicine 33, 53-61, 2017 | 34 | 2017 |
| Prothymosin α and a prothymosin α-derived peptide enhance TH1-type immune responses against defined HER-2/neu epitopes K Ioannou, E Derhovanessian, E Tsakiri, P Samara, H Kalbacher, ... BMC immunology 14, 1-14, 2013 | 27 | 2013 |
| The two cysteines of tau protein are functionally distinct and contribute differentially to its pathogenicity in vivo E Prifti, EN Tsakiri, E Vourkou, G Stamatakis, M Samiotaki, ... Journal of Neuroscience 41 (4), 797-810, 2021 | 24 | 2021 |
| The indirubin derivative 6-bromoindirubin-3′-oxime activates proteostatic modules, reprograms cellular bioenergetic pathways, and exerts antiaging effects EN Tsakiri, N Gaboriaud-Kolar, KK Iliaki, J Tchoumtchoua, ... Antioxidants & Redox Signaling 27 (14), 1027-1047, 2017 | 23 | 2017 |
| Milder degenerative effects of Carfilzomib vs. Bortezomib in the Drosophila model: a link to clinical adverse events EN Tsakiri, E Terpos, ED Papanagnou, E Kastritis, V Brieudes, ... Scientific reports 7 (1), 17802, 2017 | 21 | 2017 |
| Functional wiring of proteostatic and mitostatic modules ensures transient organismal survival during imbalanced mitochondrial dynamics S Gumeni, Z Evangelakou, EN Tsakiri, L Scorrano, IP Trougakos Redox Biology 24, 101219, 2019 | 19 | 2019 |
| Mical modulates Tau toxicity via cysteine oxidation in vivo E Prifti, EN Tsakiri, E Vourkou, G Stamatakis, M Samiotaki, EMC Skoulakis, ... Acta neuropathologica communications 10 (1), 44, 2022 | 14 | 2022 |
| Amyloid toxicity in a Drosophila Alzheimer's model is ameliorated by autophagy activation EN Tsakiri, S Gumeni, MS Manola, IP Trougakos Neurobiology of Aging 105, 137-147, 2021 | 7 | 2021 |
| Alterations in Organismal Physiology, Impaired Stress Resistance, and Accelerated Aging in Drosophila Flies Adapted to Multigenerational Proteome Instability MS Manola, EN Tsakiri, IP Trougakos Oxidative Medicine and Cellular Longevity 2019 (1), 7823285, 2019 | 6 | 2019 |
| The novel proteasome inhibitors carfilzomib and oprozomib induce milder degenerative effects compared to bortezomib when administered via oral feeding in an in vivo drosophila … E Terpos, EN Tsakiri, E Kastritis, T Bagratuni, VG Gorgoulis, IP Trougakos, ... Blood 122 (21), 1930, 2013 | 3 | 2013 |
| IQGAP1 mediates the communication between the nucleus and the mitochondria via NDUFS4 alternative splicing V Papadaki, Z Erpapazoglou, M Kokkori, ME Rogalska, M Potiri, ... NAR cancer 5 (3), zcad046, 2023 | 1 | 2023 |