| The influence of drug-like concepts on decision-making in medicinal chemistry PD Leeson, B Springthorpe Nature reviews Drug discovery 6 (11), 881-890, 2007 | 2645 | 2007 |
| An analysis of the attrition of drug candidates from four major pharmaceutical companies MJ Waring, J Arrowsmith, AR Leach, PD Leeson, S Mandrell, RM Owen, ... Nature reviews Drug discovery 14 (7), 475-486, 2015 | 1509 | 2015 |
| The role of ligand efficiency metrics in drug discovery AL Hopkins, GM Keserü, PD Leeson, DC Rees, CH Reynolds Nature reviews Drug discovery 13 (2), 105-121, 2014 | 1181 | 2014 |
| The design of leadlike combinatorial libraries SJ Teague, AM Davis, PD Leeson, T Oprea Angewandte Chemie International Edition 38 (24), 3743-3748, 1999 | 1097 | 1999 |
| Is there a difference between leads and drugs? A historical perspective TI Oprea, AM Davis, SJ Teague, PD Leeson Journal of chemical information and computer sciences 41 (5), 1308-1315, 2001 | 1058 | 2001 |
| 7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex. JA Kemp, AC Foster, PD Leeson, T Priestley, R Tridgett, LL Iversen, ... Proceedings of the National Academy of Sciences 85 (17), 6547-6550, 1988 | 701 | 1988 |
| A comparison of physiochemical property profiles of development and marketed oral drugs MC Wenlock, RP Austin, P Barton, AM Davis, PD Leeson Journal of medicinal chemistry 46 (7), 1250-1256, 2003 | 662 | 2003 |
| The glycine site of the NMDA receptor—five years on JA Kemp, PD Leeson Trends in Pharmacological Sciences 14 (1), 20-25, 1993 | 572 | 1993 |
| The glycine site on the NMDA receptor: structure-activity relationships and therapeutic potential PD Leeson, LL Iversen Journal of medicinal chemistry 37 (24), 4053-4067, 1994 | 427 | 1994 |
| Chemical beauty contest P Leeson Nature 481 (7382), 455-456, 2012 | 379 | 2012 |
| Time-related differences in the physical property profiles of oral drugs PD Leeson, AM Davis Journal of medicinal chemistry 47 (25), 6338-6348, 2004 | 370 | 2004 |
| 3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine: An Antagonist with High Affinity and Selectivity for the Human Dopamine D4 Receptor JJ Kulagowski, HB Broughton, NR Curtis, IM Mawer, MP Ridgill, R Baker, ... Journal of medicinal chemistry 39 (10), 1941-1942, 1996 | 327 | 1996 |
| From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis B Springthorpe, A Bailey, P Barton, TN Birkinshaw, RV Bonnert, ... Bioorganic & medicinal chemistry letters 17 (21), 6013-6018, 2007 | 302 | 2007 |
| 4-Amido-2-carboxytetrahydroquinolines. Structure-activity relationships for antagonism at the glycine site of the NMDA receptor PD Leeson, RW Carling, KW Moore, AM Moseley, JD Smith, G Stevenson, ... Journal of medicinal chemistry 35 (11), 1954-1968, 2002 | 256 | 2002 |
| [3H] L-655,708, a novel ligand selective for the benzodiazepine site of GABAA receptors which contain the α5 subunit K Quirk, P Blurton, S Fletcher, P Leeson, F Tang, D Mellilo, CI Ragan, ... Neuropharmacology 35 (9-10), 1331-1335, 1996 | 218 | 1996 |
| Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor S Patel, S Freedman, KL Chapman, F Emms, AE Fletcher, M Knowles, ... Journal of Pharmacology and Experimental Therapeutics 283 (2), 636-647, 1997 | 206 | 1997 |
| Kynurenic acid derivatives. Structure-activity relationships for excitatory amino acid antagonism and identification of potent and selective antagonists at the glycine site on … PD Leeson, R Baker, RW Carling, NR Curtis, KW Moore, BJ Williams, ... Journal of medicinal chemistry 34 (4), 1243-1252, 1991 | 206 | 1991 |
| 3-Phenyl-6-(2-pyridyl)methyloxy-1,2,4-triazolo[3,4-a]phthalazines and Analogues: High-Affinity γ-Aminobutyric Acid-A Benzodiazepine Receptor Ligands with α2 … RW Carling, KW Moore, LJ Street, D Wild, C Isted, PD Leeson, S Thomas, ... Journal of Medicinal Chemistry 47 (7), 1807-1822, 2004 | 187 | 2004 |
| Molecular inflation, attrition and the rule of five PD Leeson Advanced Drug Delivery Reviews 101, 22-33, 2016 | 186 | 2016 |
| The influence of the'organizational factor'on compound quality in drug discovery PD Leeson, SA St-Gallay Nature Reviews Drug Discovery 10 (10), 749-765, 2011 | 184 | 2011 |
Michael RowleyMedicinal Chemistry Consultant, Xelaro LtdDirección de correo verificada de mrowley.com
