| Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia AP Weng, AA Ferrando, W Lee, JP Morris IV, LB Silverman, ... Science 306 (5694), 269-271, 2004 | 3450 | 2004 |
| c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma AP Weng, JM Millholland, Y Yashiro-Ohtani, ML Arcangeli, A Lau, C Wai, ... Genes & development 20 (15), 2096-2109, 2006 | 1103 | 2006 |
| A trimeric structural domain of the HIV-1 transmembrane glycoprotein M Lu, SC Blacklow, PS Kim Nature structural biology 2 (12), 1075-1082, 1995 | 1013 | 1995 |
| Direct inhibition of the NOTCH transcription factor complex RE Moellering, M Cornejo, TN Davis, CD Bianco, JC Aster, SC Blacklow, ... Nature 462 (7270), 182-188, 2009 | 936 | 2009 |
| MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors L Wu, JC Aster, SC Blacklow, R Lake, S Artavanis-Tsakonas, JD Griffin Nature genetics 26 (4), 484-489, 2000 | 745 | 2000 |
| The varied roles of notch in cancer JC Aster, WS Pear, SC Blacklow Annual Review of Pathology: Mechanisms of Disease 12 (1), 245-275, 2017 | 726 | 2017 |
| Calcium depletion dissociates and activates heterodimeric notch receptors MD Rand, LM Grimm, S Artavanis-Tsakonas, V Patriub, SC Blacklow, ... Molecular and cellular biology 20 (5), 1825-1835, 2000 | 550 | 2000 |
| Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes Y Nam, P Sliz, L Song, JC Aster, SC Blacklow Cell 124 (5), 973-983, 2006 | 539 | 2006 |
| Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling AP Weng, Y Nam, MS Wolfe, WS Pear, JD Griffin, SC Blacklow, JC Aster Molecular and cellular biology 23 (2), 655-664, 2003 | 516 | 2003 |
| Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma NJ Wang, Z Sanborn, KL Arnett, LJ Bayston, W Liao, CM Proby, IM Leigh, ... Proceedings of the National Academy of Sciences 108 (43), 17761-17766, 2011 | 513 | 2011 |
| Notch directly regulates Gata3 expression during T helper 2 cell differentiation TC Fang, Y Yashiro-Ohtani, C Del Bianco, DM Knoblock, SC Blacklow, ... Immunity 27 (1), 100-110, 2007 | 485 | 2007 |
| Structural basis for autoinhibition of Notch WR Gordon, D Vardar-Ulu, G Histen, C Sanchez-Irizarry, JC Aster, ... Nature structural & molecular biology 14 (4), 295-300, 2007 | 478 | 2007 |
| Structure and physiologic function of the low-density lipoprotein receptor H Jeon, SC Blacklow Annu. Rev. Biochem. 74 (1), 535-562, 2005 | 476 | 2005 |
| Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module D Fass, S Blacklow, PS Kim, JM Berger Nature 388 (6643), 691-693, 1997 | 445 | 1997 |
| Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation N Beglova, SC Blacklow, J Takagi, TA Springer Nature structural biology 9 (4), 282-287, 2002 | 438 | 2002 |
| Mechanical allostery: evidence for a force requirement in the proteolytic activation of Notch WR Gordon, B Zimmerman, L He, LJ Miles, J Huang, K Tiyanont, ... Developmental cell 33 (6), 729-736, 2015 | 433 | 2015 |
| The molecular logic of Notch signaling–a structural and biochemical perspective WR Gordon, KL Arnett, SC Blacklow Journal of cell science 121 (19), 3109-3119, 2008 | 396 | 2008 |
| Programming peptidomimetic syntheses by translating genetic codes designed de novo AC Forster, Z Tan, MNL Nalam, H Lin, H Qu, VW Cornish, SC Blacklow Proceedings of the National Academy of Sciences 100 (11), 6353-6357, 2003 | 367 | 2003 |
| Notch signaling in leukemia JC Aster, WS Pear, SC Blacklow Annu. Rev. Pathol. Mech. Dis. 3 (1), 587-613, 2008 | 352 | 2008 |
| Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes MJ Malecki, C Sanchez-Irizarry, JL Mitchell, G Histen, ML Xu, JC Aster, ... Molecular and cellular biology 26 (12), 4642-4651, 2006 | 335 | 2006 |
Jon AsterProfessor of PathologyDirección de correo verificada de rics.bwh.harvard.edu