Artículos con órdenes de acceso público - Wenchao LuMás información
No disponibles en ningún lugar: 16
Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors
W Lu, J Wang, Y Li, H Tao, H Xiong, F Lian, J Gao, H Ma, T Lu, D Zhang, ...
European Journal of Medicinal Chemistry 184, 111767, 2019
Órdenes: Chinese Academy of Sciences, National Natural Science Foundation of China
A patent review of BRD4 inhibitors (2013-2019)
T Lu, W Lu, C Luo
Expert Opinion on Therapeutic Patents, 2020
Órdenes: Chinese Academy of Sciences, National Natural Science Foundation of China
Machine-learning-assisted approach for discovering novel inhibitors targeting bromodomain-containing protein 4
J Xing, W Lu, R Liu, Y Wang, Y Xie, H Zhang, Z Shi, H Jiang, YC Liu, ...
Journal of Chemical Information and Modeling 57 (7), 1677-1690, 2017
Órdenes: Chinese Academy of Sciences, National Natural Science Foundation of China
Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins
D Chen, T Lu, Z Yan, W Lu, F Zhou, X Lyu, B Xu, H Jiang, K Chen, C Luo, ...
European Journal of Medicinal Chemistry 182, 111633, 2019
Órdenes: Chinese Academy of Sciences, National Natural Science Foundation of China
Discovery of 1, 8-acridinedione derivatives as novel GCN5 inhibitors via high throughput screening
H Xiong, J Han, J Wang, W Lu, C Wang, Y Chen, F Lian, N Zhang, YC Liu, ...
European journal of medicinal chemistry 151, 740-751, 2018
Órdenes: Chinese Academy of Sciences, National Natural Science Foundation of China
Design, synthesis, and biological evaluation of novel DNA gyrase-inhibiting spiropyrimidinetriones as potent antibiotics for treatment of infections caused by multidrug …
C Shi, Y Zhang, T Wang, W Lu, S Zhang, B Guo, Q Chen, C Luo, X Zhou, ...
Journal of medicinal chemistry 62 (6), 2950-2973, 2019
Órdenes: Chinese Academy of Sciences
Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors
W Lu, H Xiong, Y Chen, C Wang, H Zhang, P Xu, J Han, S Xiao, H Ding, ...
Bioorganic & Medicinal Chemistry 26 (20), 5397-5407, 2018
Órdenes: Chinese Academy of Sciences, National Natural Science Foundation of China
Phospholipid-mimic oxaliplatin prodrug liposome for treatment of the metastatic triple negative breast cancer
B Feng, F Zhou, W Lu, D Wang, T Wang, C Luo, H Wang, Y Li, H Yu
Biomaterials Science 5 (8), 1522-1525, 2017
Órdenes: Chinese Academy of Sciences, National Natural Science Foundation of China
Discovery of alkoxy benzamide derivatives as novel BPTF bromodomain inhibitors via structure-based virtual screening
D Zhang, J Han, W Lu, F Lian, J Wang, T Lu, H Tao, S Xiao, F Zhang, ...
Bioorganic chemistry 86, 494-500, 2019
Órdenes: Chinese Academy of Sciences, National Natural Science Foundation of China
Identification of novel EZH2 inhibitors through pharmacophore-based virtual screening and biological assays
Y Wu, J Hu, H Ding, L Chen, Y Zhang, R Liu, P Xu, D Du, W Lu, J Liu, ...
Bioorganic & Medicinal Chemistry Letters 26 (15), 3813-3817, 2016
Órdenes: Chinese Academy of Sciences, National Natural Science Foundation of China
Discovery of high-affinity inhibitors of the BPTF bromodomain
T Lu, H Lu, Z Duan, J Wang, J Han, S Xiao, HH Chen, H Jiang, Y Chen, ...
Journal of Medicinal Chemistry 64 (16), 12075-12088, 2021
Órdenes: National Natural Science Foundation of China
Design, synthesis, and biological evaluation of tetrahydroquinolin derivatives as potent inhibitors of CBP bromodomain
Y Chen, X Bi, F Zhang, Z Sun, P Xu, H Jiang, W Lu, T Lu, H Ding, N Zhang, ...
Bioorganic Chemistry 101, 103991, 2020
Órdenes: Chinese Academy of Sciences, National Natural Science Foundation of China
The identification of novel small-molecule inhibitors targeting WDR5-MLL1 interaction through fluorescence polarization based high-throughput screening
X Ye, R Zhang, F Lian, W Zhang, W Lu, J Han, N Zhang, J Jin, C Luo, ...
Bioorganic & Medicinal Chemistry Letters 29 (4), 638-645, 2019
Órdenes: Chinese Academy of Sciences, National Natural Science Foundation of China
Structure-based drug optimization and biological evaluation of tetrahydroquinolin derivatives as selective and potent CBP bromodomain inhibitors
X Bi, Y Chen, Z Sun, W Lu, P Xu, T Lu, H Ding, N Zhang, H Jiang, K Chen, ...
Bioorganic & Medicinal Chemistry Letters 30 (22), 127480, 2020
Órdenes: Chinese Academy of Sciences, National Natural Science Foundation of China
Discovery of a highly potent CECR2 bromodomain inhibitor with 7H-pyrrolo [2, 3-d] pyrimidine scaffold
H Lu, T Lu, S Zu, Z Duan, Y Guang, Q Li, J Ma, D Chen, B Li, W Lu, ...
Bioorganic Chemistry 123, 105768, 2022
Órdenes: National Natural Science Foundation of China
ZNL0325, a pyrazolopyrimidine-based covalent probe, demonstrates an alternative binding mode for kinases
Z Li, W Lu, TS Beyett, SB Ficarro, J Jiang, J Tse, AYJ Kim, JA Marto, J Che, ...
Journal of Medicinal Chemistry 67 (4), 2837-2848, 2024
Órdenes: US National Institutes of Health
Disponibles en algún lugar: 18
Discovery and resistance mechanism of a selective CDK12 degrader
B Jiang, Y Gao, J Che, W Lu, IH Kaltheuner, R Dries, M Kalocsay, ...
Nature chemical biology 17 (6), 675-683, 2021
Órdenes: US National Institutes of Health, German Research Foundation
Computer-aided drug design in epigenetics
W Lu, R Zhang, H Jiang, H Zhang, C Luo
Frontiers in chemistry 6, 57, 2018
Órdenes: National Natural Science Foundation of China
Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling
M Fan, W Lu, J Che, NP Kwiatkowski, Y Gao, HS Seo, SB Ficarro, ...
Elife 11, e78810, 2022
Órdenes: Howard Hughes Medical Institute
Genome-Wide CRISPR Screens Identify Multiple Synthetic Lethal Targets That Enhance KRASG12C Inhibitor Efficacy
S Mukhopadhyay, HY Huang, Z Lin, M Ranieri, S Li, S Sahu, Y Liu, Y Ban, ...
Cancer research 83 (24), 4095-4111, 2023
Órdenes: US National Institutes of Health
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