| APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer’s disease patient iPSC-derived cerebral organoids J Zhao, Y Fu, Y Yamazaki, Y Ren, MD Davis, CC Liu, W Lu, X Wang, ... Nature communications 11 (1), 5540, 2020 | 278 | 2020 |
| Alzheimer’s risk factors age, APOE genotype, and sex drive distinct molecular pathways N Zhao, Y Ren, Y Yamazaki, W Qiao, F Li, LM Felton, ... Neuron 106 (5), 727-742. e6, 2020 | 208 | 2020 |
| Lipocalin-2 protects the brain during inflammatory conditions SS Kang, Y Ren, CC Liu, A Kurti, KE Baker, G Bu, Y Asmann, JD Fryer Molecular psychiatry 23 (2), 344-350, 2018 | 153 | 2018 |
| APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid N Zhao, ON Attrebi, Y Ren, W Qiao, B Sonustun, YA Martens, ... Science translational medicine 12 (529), eaay1809, 2020 | 132 | 2020 |
| Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study C Pottier, X Zhou, RB Perkerson, M Baker, GD Jenkins, DJ Serie, ... The Lancet Neurology 17 (6), 548-558, 2018 | 129 | 2018 |
| Peripheral apoE4 enhances Alzheimer’s pathology and impairs cognition by compromising cerebrovascular function CC Liu, J Zhao, Y Fu, Y Inoue, Y Ren, Y Chen, SV Doss, F Shue, ... Nature neuroscience 25 (8), 1020-1033, 2022 | 113 | 2022 |
| Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in … C Pottier, Y Ren, RB Perkerson, M Baker, GD Jenkins, M van Blitterswijk, ... Acta neuropathologica 137, 879-899, 2019 | 108 | 2019 |
| TYROBP genetic variants in early-onset Alzheimer's disease C Pottier, TA Ravenscroft, PH Brown, NCA Finch, M Baker, M Parsons, ... Neurobiology of aging 48, 222. e9-222. e15, 2016 | 99 | 2016 |
| ApoE (Apolipoprotein E) in brain pericytes regulates endothelial function in an isoform-dependent manner by modulating basement membrane components Y Yamazaki, M Shinohara, A Yamazaki, Y Ren, YW Asmann, T Kanekiyo, ... Arteriosclerosis, thrombosis, and vascular biology 40 (1), 128-144, 2020 | 77 | 2020 |
| APOE3-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia CC Liu, ME Murray, X Li, N Zhao, N Wang, MG Heckman, F Shue, ... Science translational medicine 13 (613), eabc9375, 2021 | 74 | 2021 |
| ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain T Aikawa, Y Ren, Y Yamazaki, M Tachibana, MR Johnson, CT Anderson, ... Proceedings of the National Academy of Sciences 116 (47), 23790-23796, 2019 | 69 | 2019 |
| Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease CC Liu, N Wang, Y Chen, Y Inoue, F Shue, Y Ren, M Wang, W Qiao, ... Nature immunology 24 (11), 1854-1866, 2023 | 60 | 2023 |
| Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia N Zhao, W Qiao, F Li, Y Ren, J Zheng, YA Martens, X Wang, L Li, CC Liu, ... Journal of Experimental Medicine 219 (12), e20212479, 2022 | 58 | 2022 |
| Loss of TMEM106B leads to myelination deficits: implications for frontotemporal dementia treatment strategies X Zhou, AM Nicholson, Y Ren, M Brooks, P Jiang, A Zuberi, HN Phuoc, ... Brain 143 (6), 1905-1919, 2020 | 58 | 2020 |
| Vascular ApoE4 impairs behavior by modulating gliovascular function Y Yamazaki, CC Liu, A Yamazaki, F Shue, YA Martens, Y Chen, W Qiao, ... Neuron 109 (3), 438-447. e6, 2021 | 55 | 2021 |
| Extensive transcriptomic study emphasizes importance of vesicular transport in C9orf72 expansion carriers DW Dickson, MC Baker, JL Jackson, M DeJesus-Hernandez, NCA Finch, ... Acta neuropathologica communications 7, 1-21, 2019 | 53 | 2019 |
| HLA class-I and class-II restricted neoantigen loads predict overall survival in breast cancer Y Ren, Y Cherukuri, DP Wickland, V Sarangi, S Tian, JM Carter, ... Oncoimmunology 9 (1), 1744947, 2020 | 41 | 2020 |
| TMEM106B haplotypes have distinct gene expression patterns in aged brain Y Ren, M Van Blitterswijk, M Allen, MM Carrasquillo, JS Reddy, X Wang, ... Molecular neurodegeneration 13, 1-11, 2018 | 36 | 2018 |
| Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids J Zhao, W Lu, Y Ren, Y Fu, YA Martens, F Shue, MD Davis, X Wang, ... Acta neuropathologica 142 (5), 807-825, 2021 | 35 | 2021 |
| GBA variation and susceptibility to multiple system atrophy AI Wernick, RL Walton, S Koga, AI Soto-Beasley, MG Heckman, Z Gan-Or, ... Parkinsonism & related disorders 77, 64-69, 2020 | 22 | 2020 |
Owen A. RossMayo Clinicایمیل تأیید شده در mayo.edu