| Structural basis for activity regulation of MLL family methyltransferases Y Li, J Han, Y Zhang, F Cao, Z Liu, S Li, J Wu, C Hu, Y Wang, J Shuai, ... Nature 530 (7591), 447-452, 2016 | 250 | 2016 |
| Structural and functional analyses of the mammalian TIN2-TPP1-TRF2 telomeric complex C Hu, R Rai, C Huang, C Broton, J Long, Y Xu, J Xue, M Lei, S Chang, ... Cell research 27 (12), 1485-1502, 2017 | 107 | 2017 |
| Craspase is a CRISPR RNA-guided, RNA-activated protease C Hu, SPB van Beljouw, KH Nam, G Schuler, F Ding, Y Cui, ... Science 377 (6612), 1278-1285, 2022 | 77 | 2022 |
| NBS1 phosphorylation status dictates repair choice of dysfunctional telomeres R Rai, C Hu, C Broton, Y Chen, M Lei, S Chang Molecular cell 65 (5), 801-817. e4, 2017 | 68 | 2017 |
| Structural basis for RNA-guided DNA cleavage by IscB-ωRNA and mechanistic comparison with Cas9 G Schuler, C Hu, A Ke Science 376 (6600), 1476-1481, 2022 | 63 | 2022 |
| Identification of a novel melatonin‐binding nuclear receptor: Vitamin D receptor N Fang, C Hu, W Sun, Y Xu, Y Gu, L Wu, Q Peng, RJ Reiter, L Liu Journal of pineal research 68 (1), e12618, 2020 | 52 | 2020 |
| Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools C Hu, D Ni, KH Nam, S Majumdar, J McLean, H Stahlberg, MP Terns, ... Molecular Cell 82 (82), 1–15, 2022 | 48 | 2022 |
| Mechanism for Cas4-assisted directional spacer acquisition in CRISPR–Cas C Hu, C Almendros, KH Nam, AR Costa, JNA Vink, AC Haagsma, ... Nature 598 (7881), 515-520, 2021 | 47 | 2021 |
| Real-time observation of CRISPR spacer acquisition by Cas1–Cas2 integrase AK J Budhathoki, Y Xiao, G Schuler, C Hu, A Cheng, F Ding Nature Structural & Molecular Biology, 2020 | 26 | 2020 |
| Structural insights into chromosome attachment to the nuclear envelope by an inner nuclear membrane protein Bqt4 in fission yeast C Hu, H Inoue, W Sun, Y Takeshita, Y Huang, Y Xu, J Kanoh, Y Chen Nucleic Acids Research 47 (3), 1573-1584, 2019 | 24 | 2019 |
| Microcephalin 1/BRIT1-TRF2 interaction promotes telomere replication and repair, linking telomere dysfunction to primary microcephaly A Cicconi, R Rai, X Xiong, C Broton, A Al-Hiyasat, C Hu, S Dong, W Sun, ... Nature communications 11 (1), 5861, 2020 | 23 | 2020 |
| Exploiting activation and inactivation mechanisms in type IC CRISPR-Cas3 for genome-editing applications C Hu, MT Myers, X Zhou, Z Hou, ML Lozen, KH Nam, Y Zhang, A Ke Molecular Cell 84 (3), 463-475. e5, 2024 | 14 | 2024 |
| Engineering a transposon-associated TnpB-ωRNA system for efficient gene editing and phenotypic correction of a tyrosinaemia mouse model Z Li, R Guo, X Sun, G Li, Z Shao, X Huo, R Yang, X Liu, X Cao, H Zhang, ... Nature Communications 15 (1), 831, 2024 | 13 | 2024 |
| The inner nuclear membrane protein Bqt4 in fission yeast contains a DNA-binding domain essential for telomere association with the nuclear envelope C Hu, H Inoue, W Sun, Y Takeshita, Y Huang, Y Xu, J Kanoh, Y Chen Structure 27 (2), 335-343. e3, 2019 | 13 | 2019 |
| Structure and genome editing of type IB CRISPR-Cas M Lu, C Yu, Y Zhang, W Ju, Z Ye, C Hua, J Mao, C Hu, Z Yang, Y Xiao Nature Communications 15 (1), 4126, 2024 | 7 | 2024 |
| CRISPR-repressed toxin–antitoxin provides herd immunity against anti-CRISPR elements X Shu, R Wang, Z Li, Q Xue, J Wang, J Liu, F Cheng, C Liu, H Zhao, C Hu, ... Nature Chemical Biology, 1-11, 2024 | 6 | 2024 |
| Engineering IscB to develop highly efficient miniature editing tools in mammalian cells and embryos N Xue, D Hong, D Zhang, Q Wang, S Zhang, L Yang, X Chen, Y Li, H Han, ... Molecular Cell 84 (16), 3128-3140. e4, 2024 | 2 | 2024 |
| Introducing Large Genomic Deletions in Human Pluripotent Stem Cells Using CRISPR-Cas3 YZ Zhonggang Hou,Chunyi Hu,Ailong Ke Current Protocols, 2022 | 2 | 2022 |
| Engineered IscB-ωRNA system with improved base editing efficiency for disease correction via single AAV delivery in mice R Guo, X Sun, F Wang, D Han, Q Yang, H Gao, Z Li, Z Shao, J Shi, ... Cell Reports 43 (11), 2024 | 1 | 2024 |
| Repurposing Type I-A CRISPR-Cas3 for a robust diagnosis of human papillomavirus (HPV) CXCH Tao Hu, Quanquan Ji, Xinxin Ke, Hufeng Zhou, Senfeng Zhang, Shengsheng ... Communications Biology, 2024 | 1 | 2024 |
Ailong KeRobert J. Appel Professor in Molecular Biology and Genetics, Cornell Universityایمیل تأیید شده در cornell.edu