دنبال کردن
Brendan D. Manning
Brendan D. Manning
Harvard University
ایمیل تأیید شده در hsph.harvard.edu - صفحهٔ اصلی
عنوان
نقل شده توسط
نقل شده توسط
سال
AKT/PKB signaling: navigating downstream‏
BD Manning, LC Cantley‏
Cell 129 (7), 1261-1274, 2007‏
75612007
AKT/PKB signaling: navigating the network‏
BD Manning, A Toker‏
Cell 169 (3), 381-405, 2017‏
35532017
Activation of a metabolic gene regulatory network downstream of mTOR complex 1‏
K Düvel, JL Yecies, S Menon, P Raman, AI Lipovsky, AL Souza, ...‏
Molecular cell 39 (2), 171-183, 2010‏
23562010
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway‏
BD Manning, AR Tee, MN Logsdon, J Blenis, LC Cantley‏
Molecular cell 10 (1), 151-162, 2002‏
19692002
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex‏
J Brugarolas, K Lei, RL Hurley, BD Manning, JH Reiling, E Hafen, ...‏
Genes & development 18 (23), 2893-2904, 2004‏
17272004
Targeting the PI3K-Akt pathway in human cancer: rationale and promise‏
J Luo, BD Manning, LC Cantley‏
Cancer cell 4 (4), 257-262, 2003‏
17142003
The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism‏
G Hoxhaj, BD Manning‏
Nature Reviews Cancer 20 (2), 74-88, 2020‏
16232020
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb‏
AR Tee, BD Manning, PP Roux, LC Cantley, J Blenis‏
Current biology 13 (15), 1259-1268, 2003‏
15472003
The TSC1–TSC2 complex: a molecular switchboard controlling cell growth‏
J Huang, BD Manning‏
Biochemical Journal 412 (2), 179-190, 2008‏
15182008
The LKB1 tumor suppressor negatively regulates mTOR signaling‏
RJ Shaw, N Bardeesy, BD Manning, L Lopez, M Kosmatka, RA DePinho, ...‏
Cancer cell 6 (1), 91-99, 2004‏
12912004
Tuberous sclerosis complex-1 and-2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling‏
AR Tee, DC Fingar, BD Manning, DJ Kwiatkowski, LC Cantley, J Blenis‏
Proceedings of the National Academy of Sciences 99 (21), 13571-13576, 2002‏
10462002
A complex interplay between Akt, TSC2 and the two mTOR complexes‏
J Huang, BD Manning‏
Biochemical Society Transactions 37 (1), 217-222, 2009‏
9212009
Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome‏
S Menon, CC Dibble, G Talbott, G Hoxhaj, AJ Valvezan, H Takahashi, ...‏
Cell 156 (4), 771-785, 2014‏
8892014
Stimulation of de novo pyrimidine synthesis by growth signaling through mTOR and S6K1‏
I Ben-Sahra, JJ Howell, JM Asara, BD Manning‏
Science 339 (6125), 1323-1328, 2013‏
8462013
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle‏
I Ben-Sahra, G Hoxhaj, SJH Ricoult, JM Asara, BD Manning‏
Science 351 (6274), 728-733, 2016‏
8212016
Signal integration by mTORC1 coordinates nutrient input with biosynthetic output‏
CC Dibble, BD Manning‏
Nature cell biology 15 (6), 555-564, 2013‏
8182013
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo‏
WE Dowdle, B Nyfeler, J Nagel, RA Elling, S Liu, E Triantafellow, ...‏
Nature cell biology 16 (11), 1069-1079, 2014‏
7192014
Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways‏
JL Yecies, HH Zhang, S Menon, S Liu, D Yecies, AI Lipovsky, C Gorgun, ...‏
Cell metabolism 14 (1), 21-32, 2011‏
7082011
TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1‏
CC Dibble, W Elis, S Menon, W Qin, J Klekota, JM Asara, PM Finan, ...‏
Molecular cell 47 (4), 535-546, 2012‏
7052012
The TSC1-TSC2 complex is required for proper activation of mTOR complex 2‏
J Huang, CC Dibble, M Matsuzaki, BD Manning‏
Molecular and cellular biology 28 (12), 4104-4115, 2008‏
6722008
سیستم در حال حاضر قادر به انجام عملکرد نیست. بعداً دوباره امتحان کنید.
مقاله‌ها 1–20