| Dynamic regulation of pro-and anti-inflammatory cytokines by MAPK phosphatase 1 (MKP-1) in innate immune responses H Chi, SP Barry, RJ Roth, JJ Wu, EA Jones, AM Bennett, RA Flavell Proceedings of the National Academy of Sciences 103 (7), 2274-2279, 2006 | 704 | 2006 |
| Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity JJ Wu, RJ Roth, EJ Anderson, EG Hong, MK Lee, CS Choi, PD Neufer, ... Cell metabolism 4 (1), 61-73, 2006 | 265 | 2006 |
| IL-1 signaling in obesity-induced hepatic lipogenesis and steatosis KA Negrin, RJ Roth Flach, MT DiStefano, A Matevossian, RH Friedline, ... PloS one 9 (9), e107265, 2014 | 193 | 2014 |
| The conserved misshapen-warts-Yorkie pathway acts in enteroblasts to regulate intestinal stem cells in Drosophila Q Li, S Li, S Mana-Capelli, RJR Flach, LV Danai, A Amcheslavsky, Y Nie, ... Developmental cell 31 (3), 291-304, 2014 | 153 | 2014 |
| Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis RJ Roth Flach, A Skoura, A Matevossian, LV Danai, W Zheng, C Cortes, ... Nature communications 6 (1), 8995, 2015 | 108 | 2015 |
| Hepatic mitogen-activated protein kinase phosphatase 1 selectively regulates glucose metabolism and energy homeostasis A Lawan, L Zhang, F Gatzke, K Min, MJ Jurczak, M Al-Mutairi, P Richter, ... Molecular and cellular biology 35 (1), 26-40, 2015 | 98 | 2015 |
| MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in mice RJ Roth, AM Le, L Zhang, M Kahn, VT Samuel, GI Shulman, AM Bennett The Journal of clinical investigation 119 (12), 3817-3829, 2009 | 86 | 2009 |
| Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion O Senol-Cosar, RJR Flach, M DiStefano, A Chawla, S Nicoloro, ... Nature communications 7 (1), 10686, 2016 | 69 | 2016 |
| The lipid droplet protein hypoxia-inducible gene 2 promotes hepatic triglyceride deposition by inhibiting lipolysis MT DiStefano, LV Danai, RJR Flach, A Chawla, DJ Pedersen, ... Journal of Biological Chemistry 290 (24), 15175-15184, 2015 | 68 | 2015 |
| β3-Adrenergic receptor stimulation induces E-selectin-mediated adipose tissue inflammation RJR Flach, A Matevossian, TE Akie, KA Negrin, MT Paul, MP Czech Journal of Biological Chemistry 288 (4), 2882-2892, 2013 | 64 | 2013 |
| Loss of mitogen-activated protein kinase phosphatase-1 protects from hepatic steatosis by repression of cell death-inducing DNA fragmentation factor A (DFFA)-like effector C … RJR Flach, H Qin, L Zhang, AM Bennett Journal of Biological Chemistry 286 (25), 22195-22202, 2011 | 63 | 2011 |
| MAP kinase phosphatase-1 deficiency impairs skeletal muscle regeneration and exacerbates muscular dystrophy H Shi, E Boadu, F Mercan, AM Le, RJR Flach, L Zhang, KJ Tyner, ... The FASEB Journal 24 (8), 2985, 2010 | 61 | 2010 |
| Identification of Map4k4 as a novel suppressor of skeletal muscle differentiation M Wang, SU Amano, RJR Flach, A Chawla, M Aouadi, MP Czech Molecular and cellular biology, 2013 | 45 | 2013 |
| Myeloperoxidase inhibition in mice alters atherosclerotic lesion composition RJ Roth Flach, C Su, E Bollinger, C Cortes, AW Robertson, AC Opsahl, ... PLoS One 14 (3), e0214150, 2019 | 44 | 2019 |
| Adipocyte-specific Hypoxia-inducible gene 2 promotes fat deposition and diet-induced insulin resistance MT DiStefano, RJR Flach, O Senol-Cosar, LV Danai, JV Virbasius, ... Molecular metabolism 5 (12), 1149-1161, 2016 | 42 | 2016 |
| Lymphangiogenic therapy prevents cardiac dysfunction by ameliorating inflammation and hypertension LJ Song, X Chen, TA Swanson, B LaViolette, J Pang, T Cunio, MW Nagle, ... Elife 9, e58376, 2020 | 41 | 2020 |
| NETs and traps delay wound healing in diabetes RJR Flach, MP Czech Trends in Endocrinology & Metabolism 26 (9), 451-452, 2015 | 37 | 2015 |
| Inducible deletion of protein kinase Map4k4 in obese mice improves insulin sensitivity in liver and adipose tissues LV Danai, RJ Roth Flach, JV Virbasius, L Garcia Menendez, DY Jung, ... Molecular and cellular biology 35 (13), 2356-2365, 2015 | 35 | 2015 |
| Mitogen-activated protein kinase phosphatase-1–a potential therapeutic target in metabolic disease RJ Roth Flach, AM Bennett Expert opinion on therapeutic targets 14 (12), 1323-1332, 2010 | 30 | 2010 |
| BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice E Bollinger, M Peloquin, J Libera, B Albuquerque, E Pashos, A Shipstone, ... Molecular Metabolism 66, 101611, 2022 | 29 | 2022 |
