دنبال کردن
David Matthew Wilson
David Matthew Wilson
VP & Head, Discovery Chemistry Europe, Janssen Pharmaceuticals
ایمیل تأیید شده در astrazeneca.com
عنوان
نقل شده توسط
نقل شده توسط
سال
Bedmap2: improved ice bed, surface and thickness datasets for Antarctica
P Fretwell, HD Pritchard, DG Vaughan, JL Bamber, NE Barrand, R Bell, ...
The cryosphere 7 (1), 375-393, 2013
22552013
Organic synthesis provides opportunities to transform drug discovery
DC Blakemore, L Castro, I Churcher, DC Rees, AW Thomas, DM Wilson, ...
Nature chemistry 10 (4), 383-394, 2018
13032018
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response
L Kruidenier, C Chung, Z Cheng, J Liddle, KH Che, G Joberty, ...
Nature 488 (7411), 404-408, 2012
9952012
Hallmarks of neurodegenerative diseases
DM Wilson, MR Cookson, L Van Den Bosch, H Zetterberg, DM Holtzman, ...
Cell 186 (4), 693-714, 2023
7802023
Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation
HD Lewis, J Liddle, JE Coote, SJ Atkinson, MD Barker, BD Bax, KL Bicker, ...
Nature chemical biology 11 (3), 189-191, 2015
7282015
Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia
AE Tron, MA Belmonte, A Adam, BM Aquila, LH Boise, E Chiarparin, ...
Nature communications 9 (1), 5341, 2018
5022018
Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score
RS Desikan, CC Fan, Y Wang, AJ Schork, HJ Cabral, LA Cupples, ...
PLoS medicine 14 (3), e1002258, 2017
4212017
GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer’s disease brain and improves cognitive performance in preclinical models
AD Medhurst, AR Atkins, IJ Beresford, K Brackenborough, MA Briggs, ...
The Journal of pharmacology and experimental therapeutics 321 (3), 1032-1045, 2007
3512007
Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885
AJ King, DR Patrick, RS Batorsky, ML Ho, HT Do, SY Zhang, R Kumar, ...
Cancer research 66 (23), 11100-11105, 2006
3082006
The identification of potent and selective imidazole-based inhibitors of B-Raf kinase
AK Takle, MJB Brown, S Davies, DK Dean, G Francis, A Gaiba, AW Hird, ...
Bioorganic & medicinal chemistry letters 16 (2), 378-381, 2006
2622006
Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A)
J Seal, Y Lamotte, F Donche, A Bouillot, O Mirguet, F Gellibert, ...
Bioorganic & medicinal chemistry letters 22 (8), 2968-2972, 2012
2582012
DNA damage and associated DNA repair defects in disease and premature aging
V Tiwari, DM Wilson
The American Journal of Human Genetics 105 (2), 237-257, 2019
2482019
iPTF16geu: A multiply imaged, gravitationally lensed type Ia supernova
A Goobar, R Amanullah, SR Kulkarni, PE Nugent, J Johansson, C Steidel, ...
Science 356 (6335), 291-295, 2017
2442017
Fragment-based discovery of bromodomain inhibitors part 2: optimization of phenylisoxazole sulfonamides
P Bamborough, H Diallo, JD Goodacre, L Gordon, A Lewis, JT Seal, ...
Journal of medicinal chemistry 55 (2), 587-596, 2012
2142012
EED-targeted PROTACs degrade EED, EZH2, and SUZ12 in the PRC2 complex
JHR Hsu, T Rasmusson, J Robinson, F Pachl, J Read, S Kawatkar, ...
Cell chemical biology 27 (1), 41-46. e17, 2020
1902020
Repair mechanisms for oxidative DNA damage
DM Wilson, TM Sofinowski, DR McNeill
Front Biosci 8 (1-3), d963-81, 2003
1702003
Palladium catalysed tandem cyclisation-anion capture processes. Part 3. Organoboron anion transfer agents
R Grigg, JM Sansano, V Santhakumar, V Sridharan, R Thangavelanthum, ...
Tetrahedron 53 (34), 11803-11826, 1997
1681997
Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions
RW Maul, H Saribasak, SA Martomo, RL McClure, W Yang, A Vaisman, ...
Nature immunology 12 (1), 70-76, 2011
1552011
Oxidative stress and impaired oligodendrocyte precursor cell differentiation in neurological disorders
J Spaas, L Van Veggel, M Schepers, A Tiane, J Van Horssen, ...
Cellular and Molecular Life Sciences 78 (10), 4615-4637, 2021
1522021
Potent and selective bivalent inhibitors of BET bromodomains
MJ Waring, H Chen, AA Rabow, G Walker, R Bobby, S Boiko, ...
Nature chemical biology 12 (12), 1097-1104, 2016
1472016
سیستم در حال حاضر قادر به انجام عملکرد نیست. بعداً دوباره امتحان کنید.
مقاله‌ها 1–20