Bedmap2: improved ice bed, surface and thickness datasets for Antarctica P Fretwell, HD Pritchard, DG Vaughan, JL Bamber, NE Barrand, R Bell, ... The cryosphere 7 (1), 375-393, 2013 | 2255 | 2013 |
Organic synthesis provides opportunities to transform drug discovery DC Blakemore, L Castro, I Churcher, DC Rees, AW Thomas, DM Wilson, ... Nature chemistry 10 (4), 383-394, 2018 | 1303 | 2018 |
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response L Kruidenier, C Chung, Z Cheng, J Liddle, KH Che, G Joberty, ... Nature 488 (7411), 404-408, 2012 | 995 | 2012 |
Hallmarks of neurodegenerative diseases DM Wilson, MR Cookson, L Van Den Bosch, H Zetterberg, DM Holtzman, ... Cell 186 (4), 693-714, 2023 | 780 | 2023 |
Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation HD Lewis, J Liddle, JE Coote, SJ Atkinson, MD Barker, BD Bax, KL Bicker, ... Nature chemical biology 11 (3), 189-191, 2015 | 728 | 2015 |
Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia AE Tron, MA Belmonte, A Adam, BM Aquila, LH Boise, E Chiarparin, ... Nature communications 9 (1), 5341, 2018 | 502 | 2018 |
Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score RS Desikan, CC Fan, Y Wang, AJ Schork, HJ Cabral, LA Cupples, ... PLoS medicine 14 (3), e1002258, 2017 | 421 | 2017 |
GSK189254, a novel H3 receptor antagonist that binds to histamine H3 receptors in Alzheimer’s disease brain and improves cognitive performance in preclinical models AD Medhurst, AR Atkins, IJ Beresford, K Brackenborough, MA Briggs, ... The Journal of pharmacology and experimental therapeutics 321 (3), 1032-1045, 2007 | 351 | 2007 |
Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885 AJ King, DR Patrick, RS Batorsky, ML Ho, HT Do, SY Zhang, R Kumar, ... Cancer research 66 (23), 11100-11105, 2006 | 308 | 2006 |
The identification of potent and selective imidazole-based inhibitors of B-Raf kinase AK Takle, MJB Brown, S Davies, DK Dean, G Francis, A Gaiba, AW Hird, ... Bioorganic & medicinal chemistry letters 16 (2), 378-381, 2006 | 262 | 2006 |
Identification of a novel series of BET family bromodomain inhibitors: binding mode and profile of I-BET151 (GSK1210151A) J Seal, Y Lamotte, F Donche, A Bouillot, O Mirguet, F Gellibert, ... Bioorganic & medicinal chemistry letters 22 (8), 2968-2972, 2012 | 258 | 2012 |
DNA damage and associated DNA repair defects in disease and premature aging V Tiwari, DM Wilson The American Journal of Human Genetics 105 (2), 237-257, 2019 | 248 | 2019 |
iPTF16geu: A multiply imaged, gravitationally lensed type Ia supernova A Goobar, R Amanullah, SR Kulkarni, PE Nugent, J Johansson, C Steidel, ... Science 356 (6335), 291-295, 2017 | 244 | 2017 |
Fragment-based discovery of bromodomain inhibitors part 2: optimization of phenylisoxazole sulfonamides P Bamborough, H Diallo, JD Goodacre, L Gordon, A Lewis, JT Seal, ... Journal of medicinal chemistry 55 (2), 587-596, 2012 | 214 | 2012 |
EED-targeted PROTACs degrade EED, EZH2, and SUZ12 in the PRC2 complex JHR Hsu, T Rasmusson, J Robinson, F Pachl, J Read, S Kawatkar, ... Cell chemical biology 27 (1), 41-46. e17, 2020 | 190 | 2020 |
Repair mechanisms for oxidative DNA damage DM Wilson, TM Sofinowski, DR McNeill Front Biosci 8 (1-3), d963-81, 2003 | 170 | 2003 |
Palladium catalysed tandem cyclisation-anion capture processes. Part 3. Organoboron anion transfer agents R Grigg, JM Sansano, V Santhakumar, V Sridharan, R Thangavelanthum, ... Tetrahedron 53 (34), 11803-11826, 1997 | 168 | 1997 |
Uracil residues dependent on the deaminase AID in immunoglobulin gene variable and switch regions RW Maul, H Saribasak, SA Martomo, RL McClure, W Yang, A Vaisman, ... Nature immunology 12 (1), 70-76, 2011 | 155 | 2011 |
Oxidative stress and impaired oligodendrocyte precursor cell differentiation in neurological disorders J Spaas, L Van Veggel, M Schepers, A Tiane, J Van Horssen, ... Cellular and Molecular Life Sciences 78 (10), 4615-4637, 2021 | 152 | 2021 |
Potent and selective bivalent inhibitors of BET bromodomains MJ Waring, H Chen, AA Rabow, G Walker, R Bobby, S Boiko, ... Nature chemical biology 12 (12), 1097-1104, 2016 | 147 | 2016 |