| Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system B Zetsche, JS Gootenberg, OO Abudayyeh, IM Slaymaker, KS Makarova, ... cell 163 (3), 759-771, 2015 | 5145 | 2015 |
| Rationally engineered Cas9 nucleases with improved specificity IM Slaymaker, L Gao, B Zetsche, DA Scott, WX Yan, F Zhang Science 351 (6268), 84-88, 2016 | 2787 | 2016 |
| C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector OO Abudayyeh, JS Gootenberg, S Konermann, J Joung, IM Slaymaker, ... Science 353 (6299), aaf5573, 2016 | 2401 | 2016 |
| Crystal structure of Cpf1 in complex with guide RNA and target DNA T Yamano, H Nishimasu, B Zetsche, H Hirano, IM Slaymaker, Y Li, ... Cell 165 (4), 949-962, 2016 | 795 | 2016 |
| Cas13b is a type VI-B CRISPR-associated RNA-guided RNase differentially regulated by accessory proteins Csx27 and Csx28 AA Smargon, DBT Cox, NK Pyzocha, K Zheng, IM Slaymaker, ... Molecular cell 65 (4), 618-630. e7, 2017 | 644 | 2017 |
| Directed evolution of adenine base editors with increased activity and therapeutic application NM Gaudelli, DK Lam, HA Rees, NM Solá-Esteves, LA Barrera, DA Born, ... Nature biotechnology 38 (7), 892-900, 2020 | 525 | 2020 |
| CRISPR enzymes and systems F Zhang, B Zetsche, I Slaymaker, J Gootenberg, OO Abudayyeh US Patent 9,790,490, 2017 | 506 | 2017 |
| Base editing: advances and therapeutic opportunities EM Porto, AC Komor, IM Slaymaker, GW Yeo Nature Reviews Drug Discovery 19 (12), 839-859, 2020 | 384 | 2020 |
| Chd8 mutation leads to autistic-like behaviors and impaired striatal circuits RJ Platt, Y Zhou, IM Slaymaker, AS Shetty, NR Weisbach, JA Kim, ... Cell reports 19 (2), 335-350, 2017 | 220 | 2017 |
| High-resolution structure of Cas13b and biochemical characterization of RNA targeting and cleavage IM Slaymaker, P Mesa, MJ Kellner, S Kannan, E Brignole, J Koob, ... Cell reports 26 (13), 3741-3751. e5, 2019 | 125 | 2019 |
| Rationally designed base editors for precise editing of the sickle cell disease mutation SH Chu, M Packer, H Rees, D Lam, Y Yu, J Marshall, LI Cheng, D Lam, ... The CRISPR Journal 4 (2), 169-177, 2021 | 80 | 2021 |
| CRISPR enzymes and systems F Zhang, B Zetsche, I Slaymaker, J Gootenberg, OO Abudayyeh US Patent 10,669,540, 2020 | 65 | 2020 |
| C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector. Science 353: aaf5573 OO Abudayyeh, JS Gootenberg, S Konermann, J Joung, IM Slaymaker, ... | 61 | 2016 |
| Crispr enzymes and systems F Zhang, B Zetsche, JS Gootenberg, OO Abudayyeh, I Slaymaker US Patent 11,781,172, 2023 | 60 | 2023 |
| CRISPR enzyme mutations reducing off-target effects F Zhang, L Gao, B Zetsche, I Slaymaker US Patent 10,876,100, 2020 | 43 | 2020 |
| Mini-chromosome maintenance complexes form a filament to remodel DNA structure and topology IM Slaymaker, Y Fu, DB Toso, N Ranatunga, A Brewster, SL Forsburg, ... Nucleic acids research 41 (5), 3446-3456, 2013 | 34 | 2013 |
| MCM structure and mechanics: what we have learned from archaeal MCM IM Slaymaker, XS Chen The Eukaryotic Replisome: a Guide to Protein Structure and Function, 89-111, 2012 | 34 | 2012 |
| Engineering Cas9 for human genome editing IM Slaymaker, NM Gaudelli Current Opinion in Structural Biology 69, 86-98, 2021 | 28 | 2021 |
| CRISPR–Cas9 mediated DNA unwinding detected using site-directed spin labeling NS Tangprasertchai, R Di Felice, X Zhang, IM Slaymaker, ... ACS chemical biology 12 (6), 1489-1493, 2017 | 27 | 2017 |
| CRISPR enzymes and systems F Zhang, B Zetsche, JS Gootenberg, OO Abudayyeh, I Slaymaker US Patent 10,648,020, 2020 | 26 | 2020 |
