| The challenge of new drug discovery for tuberculosis A Koul, E Arnoult, N Lounis, J Guillemont, K Andries Nature 469 (7331), 483-490, 2011 | 1347 | 2011 |
| Protein kinase G from pathogenic mycobacteria promotes survival within macrophages A Walburger, A Koul, G Ferrari, L Nguyen, C Prescianotto-Baschong, ... Science 304 (5678), 1800-1804, 2004 | 725 | 2004 |
| Diarylquinolines target subunit c of mycobacterial ATP synthase A Koul, N Dendouga, K Vergauwen, B Molenberghs, L Vranckx, ... Nature chemical biology 3 (6), 323-324, 2007 | 670 | 2007 |
| Acquired Resistance of Mycobacterium tuberculosis to Bedaquiline K Andries, C Villellas, N Coeck, K Thys, T Gevers, L Vranckx, N Lounis, ... PLOS one 9 (7), e102135, 2014 | 484 | 2014 |
| Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis A Koul, L Vranckx, N Dendouga, W Balemans, I Van den Wyngaert, ... Journal of Biological Chemistry 283 (37), 25273-25280, 2008 | 465 | 2008 |
| Interplay between mycobacteria and host signalling pathways A Koul, T Herget, B Klebl, A Ullrich Nature Reviews Microbiology 2 (3), 189-202, 2004 | 460 | 2004 |
| Early bactericidal activity and pharmacokinetics of the diarylquinoline TMC207 in treatment of pulmonary tuberculosis R Rustomjee, AH Diacon, J Allen, A Venter, C Reddy, RF Patientia, ... Antimicrobial agents and chemotherapy 52 (8), 2831-2835, 2008 | 393 | 2008 |
| Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism A Koul, L Vranckx, N Dhar, HWH Göhlmann, E Özdemir, JM Neefs, ... Nature communications 5 (1), 3369, 2014 | 305 | 2014 |
| Structure of the mycobacterial ATP synthase Fo rotor ring in complex with the anti-TB drug bedaquiline L Preiss, JD Langer, Ö Yildiz, L Eckhardt-Strelau, JEG Guillemont, A Koul, ... Science advances 1 (4), e1500106, 2015 | 300 | 2015 |
| Selectivity of TMC207 towards mycobacterial ATP synthase compared with that towards the eukaryotic homologue AC Haagsma, R Abdillahi-Ibrahim, MJ Wagner, K Krab, K Vergauwen, ... Antimicrobial agents and chemotherapy 53 (3), 1290-1292, 2009 | 285 | 2009 |
| Rates and Mechanisms of Resistance Development in Mycobacterium tuberculosis to a Novel Diarylquinoline ATP Synthase Inhibitor E Huitric, P Verhasselt, A Koul, K Andries, S Hoffner, DI Andersson Antimicrobial agents and chemotherapy 54 (3), 1022-1028, 2010 | 271 | 2010 |
| Bactericidal mode of action of bedaquiline K Hards, JR Robson, M Berney, L Shaw, D Bald, A Koul, K Andries, ... Journal of Antimicrobial Chemotherapy 70 (7), 2028-2037, 2015 | 240 | 2015 |
| Cloning and Characterization of Secretory Tyrosine Phosphatases of Mycobacterium tuberculosis A Koul, A Choidas, M Treder, AK Tyagi, K Drlica, Y Singh, A Ullrich Journal of Bacteriology 182 (19), 5425-5432, 2000 | 215 | 2000 |
| Disruption of mptpB impairs the ability of Mycobacterium tuberculosis to survive in guinea pigs R Singh, V Rao, H Shakila, R Gupta, A Khera, N Dhar, A Singh, A Koul, ... Molecular microbiology 50 (3), 751-762, 2003 | 198 | 2003 |
| Targeting Energy Metabolism in Mycobacterium tuberculosis, a New Paradigm in Antimycobacterial Drug Discovery D Bald, C Villellas, P Lu, A Koul MBio 8 (2), 10.1128/mbio. 00272-17, 2017 | 195 | 2017 |
| Probing the interaction of the diarylquinoline TMC207 with its target mycobacterial ATP synthase AC Haagsma, I Podasca, A Koul, K Andries, J Guillemont, H Lill, D Bald PloS one 6 (8), e23575, 2011 | 184 | 2011 |
| A computational model of the inhibition of Mycobacterium tuberculosis ATPase by a new drug candidate R207910 MR de Jonge, LHM Koymans, JEG Guillemont, A Koul, K Andries Proteins: Structure, Function, and Bioinformatics 67 (4), 971-980, 2007 | 177 | 2007 |
| Essentiality of FASII pathway for Staphylococcus aureus W Balemans, N Lounis, R Gilissen, J Guillemont, K Simmen, K Andries, ... Nature 463 (7279), E3-E3, 2010 | 176 | 2010 |
| Molecular mechanism of respiratory syncytial virus fusion inhibitors MB Battles, JP Langedijk, P Furmanova-Hollenstein, ... Nature chemical biology 12 (2), 87-93, 2016 | 172 | 2016 |
| The cytochrome bd-type quinol oxidase is important for survival of Mycobacterium smegmatis under peroxide and antibiotic-induced stress P Lu, MH Heineke, A Koul, K Andries, GM Cook, H Lill, R Van Spanning, ... Scientific reports 5 (1), 10333, 2015 | 141 | 2015 |