Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease PK Luukkonen, Y Zhou, S Sädevirta, M Leivonen, J Arola, M Orešič, ... Journal of hepatology 64 (5), 1167-1175, 2016 | 484 | 2016 |
Saturated fat is more metabolically harmful for the human liver than unsaturated fat or simple sugars PK Luukkonen, S Sädevirta, Y Zhou, B Kayser, A Ali, L Ahonen, ... Diabetes care 41 (8), 1732-1739, 2018 | 439 | 2018 |
Genome-wide association study of non-alcoholic fatty liver and steatohepatitis in a histologically characterised cohort☆ QM Anstee, R Darlay, S Cockell, M Meroni, O Govaere, D Tiniakos, ... Journal of hepatology 73 (3), 505-515, 2020 | 434 | 2020 |
Quantitative PCR provides a simple and accessible method for quantitative microbiota profiling C Jian, P Luukkonen, H Yki-Järvinen, A Salonen, K Korpela PloS one 15 (1), e0227285, 2020 | 366 | 2020 |
Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: A systematic review and meta-analysis EA Selvaraj, FE Mózes, ANA Jayaswal, MH Zafarmand, Y Vali, JA Lee, ... Journal of hepatology 75 (4), 770-785, 2021 | 298 | 2021 |
Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease PK Luukkonen, S Dufour, K Lyu, XM Zhang, A Hakkarainen, TE Lehtimäki, ... Proceedings of the National Academy of Sciences 117 (13), 7347-7354, 2020 | 225 | 2020 |
Dietary carbohydrates and fats in nonalcoholic fatty liver disease H Yki-Järvinen, PK Luukkonen, L Hodson, JB Moore Nature reviews Gastroenterology & hepatology 18 (11), 770-786, 2021 | 210 | 2021 |
Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease P Sen, S Qadri, PK Luukkonen, O Ragnarsdottir, A McGlinchey, S Jäntti, ... Journal of hepatology 76 (2), 283-293, 2022 | 200 | 2022 |
The MBOAT7 variant rs641738 alters hepatic phosphatidylinositols and increases severity of non-alcoholic fatty liver disease in humans PK Luukkonen, Y Zhou, T Hyotylainen, M Leivonen, J Arola, ... Journal of hepatology 65 (6), 1263-1265, 2016 | 192 | 2016 |
Human PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acids PK Luukkonen, A Nick, M Hölttä-Vuori, C Thiele, E Isokuortti, ... JCI insight 4 (16), e127902, 2019 | 152 | 2019 |
Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD PK Luukkonen, Y Zhou, PAN Haridas, OP Dwivedi, T Hyötyläinen, A Ali, ... Journal of hepatology 67 (1), 128-136, 2017 | 151 | 2017 |
Distinct contributions of metabolic dysfunction and genetic risk factors in the pathogenesis of non-alcoholic fatty liver disease PK Luukkonen, S Qadri, N Ahlholm, K Porthan, V Männistö, ... Journal of hepatology 76 (3), 526-535, 2022 | 147 | 2022 |
Exome-wide association study on alanine aminotransferase identifies sequence variants in the GPAM and APOE associated with fatty liver disease O Jamialahmadi, RM Mancina, E Ciociola, F Tavaglione, PK Luukkonen, ... Gastroenterology 160 (5), 1634-1646. e7, 2021 | 123 | 2021 |
rs641738C> T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis K Teo, KWM Abeysekera, L Adams, E Aigner, QM Anstee, JM Banales, ... Journal of hepatology 74 (1), 20-30, 2021 | 123 | 2021 |
A membrane-bound diacylglycerol species induces PKCϵ-mediated hepatic insulin resistance K Lyu, Y Zhang, D Zhang, M Kahn, KW Ter Horst, MRS Rodrigues, ... Cell metabolism 32 (4), 654-664. e5, 2020 | 123 | 2020 |
LPIAT1/MBOAT7 depletion increases triglyceride synthesis fueled by high phosphatidylinositol turnover Y Tanaka, Y Shimanaka, A Caddeo, T Kubo, Y Mao, T Kubota, N Kubota, ... Gut 70 (1), 180-193, 2021 | 120 | 2021 |
Hydroxysteroid 17-β dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease PK Luukkonen, T Tukiainen, A Juuti, H Sammalkorpi, PAN Haridas, ... JCI insight 5 (5), e132158, 2020 | 92 | 2020 |
MARC1 variant rs2642438 increases hepatic phosphatidylcholines and decreases severity of non-alcoholic fatty liver disease in humans PK Luukkonen, A Juuti, H Sammalkorpi, AK Penttilä, M Oresic, ... Journal of Hepatology 73 (3), 725-726, 2020 | 68 | 2020 |
Impact of short-term overfeeding of saturated or unsaturated fat or sugars on the gut microbiota in relation to liver fat in obese and overweight adults C Jian, P Luukkonen, S Sädevirta, H Yki-Järvinen, A Salonen Clinical Nutrition 40 (1), 207-216, 2021 | 54 | 2021 |
Obesity modifies the performance of fibrosis biomarkers in nonalcoholic fatty liver disease S Qadri, N Ahlholm, I Lønsmann, P Pellegrini, A Poikola, PK Luukkonen, ... The Journal of Clinical Endocrinology & Metabolism 107 (5), e2008-e2020, 2022 | 50 | 2022 |