| Discovery of highly potent, selective, and orally efficacious p300/CBP histone acetyltransferases inhibitors Y Yang, R Zhang, Z Li, L Mei, S Wan, H Ding, Z Chen, J Xing, H Feng, ... Journal of medicinal chemistry 63 (3), 1337-1360, 2020 | 111 | 2020 |
| Computer-aided drug design in epigenetics W Lu, R Zhang, H Jiang, H Zhang, C Luo Frontiers in chemistry 6, 57, 2018 | 80 | 2018 |
| Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity H Fan, S Xia, J Xiang, Y Li, MO Ross, SA Lim, F Yang, J Tu, L Xie, ... Nature 623 (7989), 1034-1043, 2023 | 54 | 2023 |
| Biochemical studies and molecular dynamic simulations reveal the molecular basis of conformational changes in DNA methyltransferase-1 F Ye, X Kong, H Zhang, Y Liu, Z Shao, J Jin, Y Cai, R Zhang, L Li, ... ACS chemical biology 13 (3), 772-781, 2018 | 34 | 2018 |
| Discovery of novel DNA methyltransferase 3A inhibitors via structure-based virtual screening and biological assays Z Shao, P Xu, W Xu, L Li, S Liu, R Zhang, YC Liu, C Zhang, S Chen, ... Bioorganic & Medicinal Chemistry Letters 27 (2), 342-346, 2017 | 28 | 2017 |
| Covalent inhibitors allosterically block the activation of Rho family proteins and suppress cancer cell invasion Z Sun, H Zhang, Y Zhang, L Liao, W Zhou, F Zhang, F Lian, J Huang, P Xu, ... Advanced Science 7 (14), 2000098, 2020 | 21 | 2020 |
| Rational design of 5-((1H-imidazol-1-yl) methyl) quinolin-8-ol derivatives as novel bromodomain-containing protein 4 inhibitors J Xing, R Zhang, X Jiang, T Hu, X Wang, G Qiao, J Wang, F Yang, X Luo, ... European Journal of Medicinal Chemistry 163, 281-294, 2019 | 21 | 2019 |
| Identification of novel inhibitors of histone acetyltransferase hMOF through high throughput screening R Zhang, J Wang, L Zhao, S Liu, D Du, H Ding, S Chen, L Yue, YC Liu, ... European Journal of Medicinal Chemistry 157, 867-876, 2018 | 18 | 2018 |
| Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells D Chen, S Xia, R Zhang, Y Li, CA Famulare, H Fan, R Wu, M Wang, ... Molecular cell 81 (18), 3833-3847. e11, 2021 | 17 | 2021 |
| Lead discovery, chemical optimization, and biological evaluation studies of novel histone methyltransferase SET7 small-molecule inhibitors Z Hou, W Min, R Zhang, A Niu, Y Li, L Cao, J Han, C Luo, P Yang, H Ding Bioorganic & Medicinal Chemistry Letters 30 (9), 127061, 2020 | 15 | 2020 |
| The identification of novel small-molecule inhibitors targeting WDR5-MLL1 interaction through fluorescence polarization based high-throughput screening X Ye, R Zhang, F Lian, W Zhang, W Lu, J Han, N Zhang, J Jin, C Luo, ... Bioorganic & Medicinal Chemistry Letters 29 (4), 638-645, 2019 | 11 | 2019 |
| Discovery of trisubstituted nicotinonitrile derivatives as novel human GCN5 inhibitors through AlphaScreen-based high throughput screening H Tao, J Wang, W Lu, R Zhang, Y Xie, YC Liu, R Liu, L Yue, K Chen, ... RSC advances 9 (9), 4917-4924, 2019 | 10 | 2019 |
| Lyso-PAF, a biologically inactive phospholipid, contributes to RAF1 activation X Gao, Y Liu, Y Li, H Fan, R Wu, R Zhang, B Faubert, YY He, ... Molecular cell 82 (11), 1992-2005. e9, 2022 | 9 | 2022 |
| NRAS Mutant Dictates AHCYL1-Governed ER Calcium Homeostasis for Melanoma Tumor Growth C Cai, J Tu, J Najarro, R Zhang, H Fan, FQ Zhang, J Li, Z Xie, R Su, ... Molecular Cancer Research 22 (4), 386-401, 2024 | 6 | 2024 |
| Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells R Zhang, D Chen, H Fan, R Wu, J Tu, FQ Zhang, M Wang, H Zheng, ... Cell chemical biology 29 (7), 1200-1208. e6, 2022 | 4 | 2022 |
| Small molecule inhibitors targeting new targets of protein-protein interactions L Yue, W Wan, P Xu, L Li, C Wang, Y Zhang, H Xu, R Zhang, J Hu, W Lu, ... Targeting Protein-Protein Interactions by Small Molecules, 179-211, 2018 | 1 | 2018 |
| Histone acetyltransferase (HAT) inhibitor and use thereof B Zhou, C Luo, H Jiang, Y Yaxi, L Mei, W Lu, X Senhao, S Chen, S Wan, ... US Patent 12,172,989, 2024 | | 2024 |
| AHCYL1 is crucial for NRAS mutant-expressing melanoma tumor growth by governing ER calcium homeostasis C Cai, J Tu, J Najarro, R Zhang, X Gao, H Fan, F Zhang, J Li, M Ciboddo, ... Cancer Research 83 (7_Supplement), 283-283, 2023 | | 2023 |
| The canonical Wnt pathway leads to regulation of gene transcription. Menu R Zhang, J Wang, L Zhao, S Liu, D Du, H Ding, S Chen, L Yue, YC Liu, ... | | |