| Efficient genome editing in zebrafish using a CRISPR-Cas system WY Hwang, Y Fu, D Reyon, ML Maeder, SQ Tsai, JD Sander, ... Nature biotechnology 31 (3), 227-229, 2013 | 3865 | 2013 |
| High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects BP Kleinstiver, V Pattanayak, MS Prew, SQ Tsai, NT Nguyen, Z Zheng, ... Nature 529 (7587), 490-495, 2016 | 3015 | 2016 |
| GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases SQ Tsai, Z Zheng, NT Nguyen, M Liebers, VV Topkar, V Thapar, ... Nature biotechnology 33 (2), 187-197, 2015 | 2448 | 2015 |
| Engineered CRISPR-Cas9 nucleases with altered PAM specificities BP Kleinstiver, MS Prew, SQ Tsai, VV Topkar, NT Nguyen, Z Zheng, ... Nature 523 (7561), 481-485, 2015 | 1984 | 2015 |
| FLASH assembly of TALENs for high-throughput genome editing D Reyon, SQ Tsai, C Khayter, JA Foden, JD Sander, JK Joung Nature biotechnology 30 (5), 460-465, 2012 | 1583 | 2012 |
| Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing SQ Tsai, N Wyvekens, C Khayter, JA Foden, V Thapar, D Reyon, ... Nature biotechnology 32 (6), 569-576, 2014 | 1314 | 2014 |
| CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR–Cas9 nuclease off-targets SQ Tsai, NT Nguyen, J Malagon-Lopez, VV Topkar, MJ Aryee, JK Joung Nature methods 14 (6), 607-614, 2017 | 806 | 2017 |
| Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition BP Kleinstiver, MS Prew, SQ Tsai, NT Nguyen, VV Topkar, Z Zheng, ... Nature biotechnology 33 (12), 1293-1298, 2015 | 755 | 2015 |
| Genome-wide specificities of CRISPR-Cas Cpf1 nucleases in human cells BP Kleinstiver, SQ Tsai, MS Prew, NT Nguyen, MM Welch, JM Lopez, ... Nature biotechnology 34 (8), 869-874, 2016 | 751 | 2016 |
| Toddler: an embryonic signal that promotes cell movement via Apelin receptors A Pauli, ML Norris, E Valen, GL Chew, JA Gagnon, S Zimmerman, ... Science 343 (6172), 1248636, 2014 | 681 | 2014 |
| Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins ML Maeder, JF Angstman, ME Richardson, SJ Linder, VM Cascio, ... Nature biotechnology 31 (12), 1137-1142, 2013 | 611 | 2013 |
| Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells J Liao, R Karnik, H Gu, MJ Ziller, K Clement, AM Tsankov, V Akopian, ... Nature genetics 47 (5), 469-478, 2015 | 567 | 2015 |
| Defining and improving the genome-wide specificities of CRISPR–Cas9 nucleases SQ Tsai, JK Joung Nature Reviews Genetics 17 (5), 300-312, 2016 | 549 | 2016 |
| Highly efficient therapeutic gene editing of human hematopoietic stem cells Y Wu, J Zeng, BP Roscoe, P Liu, Q Yao, CR Lazzarotto, K Clement, ... Nature medicine 25 (5), 776-783, 2019 | 498 | 2019 |
| Genetic inactivation of CD33 in hematopoietic stem cells to enable CAR T cell immunotherapy for acute myeloid leukemia MY Kim, KR Yu, SS Kenderian, M Ruella, S Chen, TH Shin, AA Aljanahi, ... Cell 173 (6), 1439-1453. e19, 2018 | 463 | 2018 |
| High levels of AAV vector integration into CRISPR-induced DNA breaks KS Hanlon, BP Kleinstiver, SP Garcia, MP Zaborowski, A Volak, SE Spirig, ... Nature communications 10 (1), 4439, 2019 | 390 | 2019 |
| In vivo CRISPR editing with no detectable genome-wide off-target mutations P Akcakaya, ML Bobbin, JA Guo, J Malagon-Lopez, K Clement, SP Garcia, ... Nature 561 (7723), 416-419, 2018 | 352 | 2018 |
| Highly efficient generation of heritable zebrafish gene mutations using homo-and heterodimeric TALENs L Cade, D Reyon, WY Hwang, SQ Tsai, S Patel, C Khayter, JK Joung, ... Nucleic acids research 40 (16), 8001-8010, 2012 | 320 | 2012 |
| Base editing of haematopoietic stem cells rescues sickle cell disease in mice GA Newby, JS Yen, KJ Woodard, T Mayuranathan, CR Lazzarotto, Y Li, ... Nature 595 (7866), 295-302, 2021 | 316 | 2021 |
| Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity JP Guilinger, V Pattanayak, D Reyon, SQ Tsai, JD Sander, JK Joung, ... Nature methods 11 (4), 429-435, 2014 | 303 | 2014 |
Martin J. AryeeAssociate Professor, Dept of Data Science, Dana Farber Cancer Institute & Dept of Pathology, Harvardایمیل تأیید شده در ds.dfci.harvard.edu
