| Induction of NF-κB by the Akt/PKB kinase LP Kane, VS Shapiro, D Stokoe, A Weiss Current Biology 9 (11), 601-604, 1999 | 1171 | 1999 |
| Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells AC Anderson, DE Anderson, L Bregoli, WD Hastings, N Kassam, C Lei, ... Science 318 (5853), 1141-1143, 2007 | 847 | 2007 |
| Signal transduction by the TCR for antigen LP Kane, J Lin, A Weiss Current opinion in immunology 12 (3), 242-249, 2000 | 686 | 2000 |
| Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines LP Kane, PG Andres, KC Howland, AK Abbas, A Weiss Nature immunology 2 (1), 37-44, 2001 | 409 | 2001 |
| The PI‐3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3 LP Kane, A Weiss Immunological reviews 192 (1), 7-20, 2003 | 334 | 2003 |
| Phosphotyrosine-dependent coupling of Tim-3 to T-cell receptor signaling pathways J Lee, EW Su, C Zhu, S Hainline, J Phuah, JA Moroco, TE Smithgall, ... Molecular and cellular biology, 2011 | 316 | 2011 |
| Adaptive resistance to anti-PD1 therapy by Tim-3 upregulation is mediated by the PI3K-Akt pathway in head and neck cancer G Shayan, R Srivastava, J Li, N Schmitt, LP Kane, RL Ferris Oncoimmunology 6 (1), e1261779, 2017 | 312 | 2017 |
| TIM-3 as a target for cancer immunotherapy and mechanisms of action W Du, M Yang, A Turner, C Xu, RL Ferris, J Huang, LP Kane, B Lu International journal of molecular sciences 18 (3), 645, 2017 | 268 | 2017 |
| PD-1/SHP-2 inhibits Tc1/Th1 phenotypic responses and the activation of T cells in the tumor microenvironment J Li, HB Jie, Y Lei, N Gildener-Leapman, S Trivedi, T Green, LP Kane, ... Cancer research 75 (3), 508-518, 2015 | 257 | 2015 |
| It's all Rel-ative: NF-κB and CD28 costimulation of T-cell activation LP Kane, J Lin, A Weiss Trends in immunology 23 (8), 413-420, 2002 | 254 | 2002 |
| Too much of a good thing? Tim-3 and TCR signaling in T cell exhaustion RL Ferris, B Lu, LP Kane The Journal of Immunology 193 (4), 1525-1530, 2014 | 221 | 2014 |
| Dominant role of antigen dose in CD4+ Foxp3+ regulatory T cell induction and expansion MS Turner, LP Kane, PA Morel The Journal of Immunology 183 (8), 4895-4903, 2009 | 209 | 2009 |
| Two signals are required for negative selection of CD4+ CD8+ thymocytes. DM Page, LP Kane, JP Allison, SM Hedrick Journal of immunology (Baltimore, Md.: 1950) 151 (4), 1868-1880, 1993 | 202 | 1993 |
| Akt-dependent phosphorylation specifically regulates Cot induction of NF-κB-dependent transcription LP Kane, MN Mollenauer, Z Xu, CW Turck, A Weiss Molecular and cellular biology 22 (16), 5962-5974, 2002 | 201 | 2002 |
| T cell Ig and mucin 1 (TIM-1) is expressed on in vivo-activated T cells and provides a costimulatory signal for T cell activation AJ de Souza, TB Oriss, KJ O'malley, A Ray, LP Kane Proceedings of the National Academy of Sciences 102 (47), 17113-17118, 2005 | 195 | 2005 |
| Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin AH Verma, JP Richardson, C Zhou, BM Coleman, DL Moyes, J Ho, ... Science immunology 2 (17), eaam8834, 2017 | 194 | 2017 |
| Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion L Avery, J Filderman, AL Szymczak-Workman, LP Kane Proceedings of the national academy of sciences 115 (10), 2455-2460, 2018 | 175 | 2018 |
| Disruption of Akt kinase activation is important for immunosuppression induced by measles virus E Avota, A Avots, S Niewiesk, LP Kane, U Bommhardt, V Ter Meulen, ... Nature medicine 7 (6), 725-731, 2001 | 159 | 2001 |
| A Nck‐Pak1 signaling module is required for T‐cell receptor‐mediated activation of NFAT, but not of JNK D Yablonski, LP Kane, D Qian, A Weiss The EMBO journal, 1998 | 156 | 1998 |
| IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail AW Ho, F Shen, HR Conti, N Patel, EE Childs, AC Peterson, ... The Journal of Immunology 185 (2), 1063-1070, 2010 | 145 | 2010 |
Stephen M HedrickUniversity of California, San Diegoایمیل تأیید شده در ucsd.edu
