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William Greenlee
William Greenlee
Medchem Discovery Consulting
Vahvistettu sähköpostiosoite verkkotunnuksessa william-greenlee.com
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A new class of angiotensin-converting enzyme inhibitors
AA Patchett, E Harris, EW Tristram, MJ Wyvratt, MT Wu, D Taub, ...
Nature 288 (5788), 280-283, 1980
9781980
SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo
JM Strizki, S Xu, NE Wagner, L Wojcik, J Liu, Y Hou, M Endres, A Palani, ...
Proceedings of the National Academy of Sciences 98 (22), 12718-12723, 2001
4472001
Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy
RR Wexler, WJ Greenlee, JD Irvin, MR Goldberg, K Prendergast, ...
Journal of Medicinal Chemistry 39 (3), 625-656, 1996
4121996
Renin inhibitors.
WJ Greenlee
Medicinal research reviews 10 (2), 173-236, 1990
3651990
Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activity
S Chackalamannil, Y Wang, WJ Greenlee, Z Hu, Y Xia, HS Ahn, ...
Journal of medicinal chemistry 51 (11), 3061-3064, 2008
3362008
5-Chloro-3-(phenylsulfonyl) indole-2-carboxamide: a novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase
TM Williams, TM Ciccarone, SC MacTough, CS Rooney, SK Balani, ...
Journal of medicinal chemistry 36 (9), 1291-1294, 1993
3111993
Identification of peptide binding residues in the extracellular domains of the AT1 receptor.
SA Hjorth, HT Schambye, WJ Greenlee, TW Schwartz
Journal of Biological Chemistry 269 (49), 30953-30959, 1994
2271994
Discovery of the 3-imino-1, 2, 4-thiadiazinane 1, 1-dioxide derivative verubecestat (MK-8931)–a β-site amyloid precursor protein cleaving enzyme 1 inhibitor for the treatment …
JD Scott, SW Li, APJ Brunskill, X Chen, K Cox, JN Cumming, M Forman, ...
Journal of medicinal chemistry 59 (23), 10435-10450, 2016
1752016
Discovery of cyclic acylguanidines as highly potent and selective β-site amyloid cleaving enzyme (BACE) inhibitors: Part I Inhibitor design and validation
Z Zhu, ZY Sun, Y Ye, J Voigt, C Strickland, EM Smith, J Cumming, L Wang, ...
Journal of medicinal chemistry 53 (3), 951-965, 2010
1732010
Potent, selective, and orally active adenosine A2A receptor antagonists: arylpiperazine derivatives of pyrazolo [4, 3-e]-1, 2, 4-triazolo [1, 5-c] pyrimidines
BR Neustadt, J Hao, N Lindo, WJ Greenlee, AW Stamford, D Tulshian, ...
Bioorganic & Medicinal Chemistry Letters 17 (5), 1376-1380, 2007
1702007
Substituted imidazo-fused 6-membered heterocycles as angiotensin II antagonists
PK Chakravarty, WJ Greenlee, NB Mantlo, AA Patchett, TF Walsh
US Patent 5,332,744, 1994
1671994
Application of fragment-based NMR screening, X-ray crystallography, structure-based design, and focused chemical library design to identify novel μM leads for the development …
YS Wang, C Strickland, JH Voigt, ME Kennedy, BM Beyer, MM Senior, ...
Journal of medicinal chemistry 53 (3), 942-950, 2010
1622010
Total synthesis of cytochalasin B
G Stork, Y Nakahara, Y Nakahara, WJ Greenlee
Journal of the American Chemical Society 100 (24), 7775-7777, 1978
1611978
Discovery of potent orally active thrombin receptor (protease activated receptor 1) antagonists as novel antithrombotic agents
S Chackalamannil, Y Xia, WJ Greenlee, M Clasby, D Doller, H Tsai, ...
Journal of medicinal chemistry 48 (19), 5884-5887, 2005
1572005
Structure based design of iminohydantoin BACE1 inhibitors: identification of an orally available, centrally active BACE1 inhibitor
JN Cumming, EM Smith, L Wang, J Misiaszek, J Durkin, J Pan, U Iserloh, ...
Bioorganic & medicinal chemistry letters 22 (7), 2444-2449, 2012
1562012
Discovery of 4-[(Z)-(4-Bromophenyl)- (ethoxyimino)methyl]-1‘-[(2,4-dimethyl-3- pyridinyl)carbonyl]-4‘-methyl-1,4‘- bipiperidine N-Oxide (SCH 351125):  An Orally …
A Palani, S Shapiro, JW Clader, WJ Greenlee, K Cox, J Strizki, M Endres, ...
Journal of medicinal chemistry 44 (21), 3339-3342, 2001
1522001
In vitro pharmacology of L-158,809, a new highly potent and selective angiotensin II receptor antagonist.
RS Chang, PK Siegl, BV Clineschmidt, NB Mantlo, PK Chakravarty, ...
The Journal of pharmacology and experimental therapeutics 262 (1), 133-138, 1992
1411992
A potent, orally active, balanced affinity angiotensin II AT1 antagonist and AT2 binding inhibitor
SE de Laszlo, CS Quagliato, WJ Greenlee, AA Patchett, RSL Chang, ...
Journal of medicinal chemistry 36 (21), 3207-3210, 1993
1391993
Heterocyclic aspartyl protease inhibitors
Z Zhu, BA McKittrick, ZY Sun, CY Yuanzan, JH Voigt, C Strickland, ...
US Patent 7,700,603, 2010
1352010
Design of a selective insulin receptor tyrosine kinase inhibitor and its effect on glucose uptake and metabolism in intact cells
R Saperstein, PP Vicario, HV Strout, E Brady, EE Slater, WJ Greenlee, ...
Biochemistry 28 (13), 5694-5701, 1989
1331989
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Artikkelit 1–20