Seuraa
Stephen Beers
Stephen Beers
Professor of Immunology and Immunotherapy, Centre for Cancer Immunology, University of Southampton
Vahvistettu sähköpostiosoite verkkotunnuksessa soton.ac.uk - Kotisivu
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Viittaukset
Viittaukset
Vuosi
The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20
JL Teeling, WJM Mackus, LJJM Wiegman, JHN van den Brakel, SA Beers, ...
The Journal of Immunology 177 (1), 362-371, 2006
8532006
Fc-optimized anti-CD25 depletes tumor-infiltrating regulatory T cells and synergizes with PD-1 blockade to eradicate established tumors
FA Vargas, AJS Furness, I Solomon, K Joshi, L Mekkaoui, MH Lesko, ...
Immunity 46 (4), 577-586, 2017
4562017
Antigenic modulation limits the efficacy of anti-CD20 antibodies: implications for antibody selection
SA Beers, RR French, HTC Chan, SH Lim, TC Jarrett, RM Vidal, ...
Blood, The Journal of the American Society of Hematology 115 (25), 5191-5201, 2010
4192010
Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignancies
W Alduaij, A Ivanov, J Honeychurch, EJ Cheadle, S Potluri, SH Lim, ...
Blood, The Journal of the American Society of Hematology 117 (17), 4519-4529, 2011
3582011
Anti-CD20 monoclonal antibodies: historical and future perspectives
SH Lim, SA Beers, RR French, PWM Johnson, MJ Glennie, MS Cragg
haematologica 95 (1), 135, 2009
3442009
Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy
SH Lim, AT Vaughan, M Ashton-Key, EL Williams, SV Dixon, HTC Chan, ...
Blood, The Journal of the American Society of Hematology 118 (9), 2530-2540, 2011
3152011
CD20 as a target for therapeutic type I and II monoclonal antibodies
SA Beers, CHT Chan, RR French, MS Cragg, MJ Glennie
Seminars in hematology 47 (2), 107-114, 2010
2932010
Interaction with FcγRIIB is critical for the agonistic activity of anti-CD40 monoclonal antibody
AL White, HT Chan, A Roghanian, RR French, CI Mockridge, AL Tutt, ...
The Journal of Immunology 187 (4), 1754-1763, 2011
2902011
Type II (tositumomab) anti-CD20 monoclonal antibody out performs type I (rituximab-like) reagents in B-cell depletion regardless of complement activation
SA Beers, CHT Chan, S James, RR French, KE Attfield, CM Brennan, ...
Blood, The Journal of the American Society of Hematology 112 (10), 4170-4177, 2008
2532008
Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells
A Ivanov, SA Beers, CA Walshe, J Honeychurch, W Alduaij, KL Cox, ...
The Journal of clinical investigation 119 (8), 2143-2159, 2009
2392009
Conformation of the human immunoglobulin G2 hinge imparts superagonistic properties to immunostimulatory anticancer antibodies
AL White, HTC Chan, RR French, J Willoughby, CI Mockridge, ...
Cancer cell 27 (1), 138-148, 2015
2352015
Induction of cytosolic calcium flux by CD20 is dependent upon B Cell antigen receptor signaling
CA Walshe, SA Beers, RR French, CHT Chan, PW Johnson, GK Packham, ...
Journal of Biological Chemistry 283 (25), 16971-16984, 2008
2152008
Fc-engineering for modulated effector functions—improving antibodies for cancer treatment
R Liu, RJ Oldham, E Teal, SA Beers, MS Cragg
Antibodies 9 (4), 64, 2020
1892020
The antibacterial properties of secreted phospholipases A2: a major physiological role for the group IIA enzyme that depends on the very high pI of the enzyme to allow …
SA Beers, AG Buckland, RS Koduri, W Cho, MH Gelb, DC Wilton
Journal of Biological Chemistry 277 (3), 1788-1793, 2002
1652002
Antagonistic human FcγRIIB (CD32B) antibodies have anti-tumor activity and overcome resistance to antibody therapy in vivo
A Roghanian, I Teige, L Mårtensson, KL Cox, M Kovacek, A Ljungars, ...
Cancer cell 27 (4), 473-488, 2015
1572015
Antibodies to costimulatory receptor 4-1BB enhance anti-tumor immunity via T regulatory cell depletion and promotion of CD8 T cell effector function
SL Buchan, L Dou, M Remer, SG Booth, SN Dunn, C Lai, M Semmrich, ...
Immunity 49 (5), 958-970. e7, 2018
1422018
Influence of immunoglobulin isotype on therapeutic antibody function
SA Beers, MJ Glennie, AL White
Blood, The Journal of the American Society of Hematology 127 (9), 1097-1101, 2016
1402016
Antigenic modulation limits the effector cell mechanisms employed by type I anti-CD20 monoclonal antibodies
TRW Tipton, A Roghanian, RJ Oldham, MJ Carter, KL Cox, CI Mockridge, ...
Blood, The Journal of the American Society of Hematology 125 (12), 1901-1909, 2015
922015
Inhibitory FcγRIIb (CD32b) becomes activated by therapeutic mAb in both cis and trans and drives internalization according to antibody specificity
AT Vaughan, C Iriyama, SA Beers, CHT Chan, SH Lim, EL Williams, ...
Blood, The Journal of the American Society of Hematology 123 (5), 669-677, 2014
872014
STING activation reverses lymphoma-mediated resistance to antibody immunotherapy
LN Dahal, L Dou, K Hussain, R Liu, A Earley, KL Cox, S Murinello, I Tracy, ...
Cancer research 77 (13), 3619-3631, 2017
832017
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