The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20 JL Teeling, WJM Mackus, LJJM Wiegman, JHN van den Brakel, SA Beers, ... The Journal of Immunology 177 (1), 362-371, 2006 | 853 | 2006 |
Fc-optimized anti-CD25 depletes tumor-infiltrating regulatory T cells and synergizes with PD-1 blockade to eradicate established tumors FA Vargas, AJS Furness, I Solomon, K Joshi, L Mekkaoui, MH Lesko, ... Immunity 46 (4), 577-586, 2017 | 456 | 2017 |
Antigenic modulation limits the efficacy of anti-CD20 antibodies: implications for antibody selection SA Beers, RR French, HTC Chan, SH Lim, TC Jarrett, RM Vidal, ... Blood, The Journal of the American Society of Hematology 115 (25), 5191-5201, 2010 | 419 | 2010 |
Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignancies W Alduaij, A Ivanov, J Honeychurch, EJ Cheadle, S Potluri, SH Lim, ... Blood, The Journal of the American Society of Hematology 117 (17), 4519-4529, 2011 | 358 | 2011 |
Anti-CD20 monoclonal antibodies: historical and future perspectives SH Lim, SA Beers, RR French, PWM Johnson, MJ Glennie, MS Cragg haematologica 95 (1), 135, 2009 | 344 | 2009 |
Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy SH Lim, AT Vaughan, M Ashton-Key, EL Williams, SV Dixon, HTC Chan, ... Blood, The Journal of the American Society of Hematology 118 (9), 2530-2540, 2011 | 315 | 2011 |
CD20 as a target for therapeutic type I and II monoclonal antibodies SA Beers, CHT Chan, RR French, MS Cragg, MJ Glennie Seminars in hematology 47 (2), 107-114, 2010 | 293 | 2010 |
Interaction with FcγRIIB is critical for the agonistic activity of anti-CD40 monoclonal antibody AL White, HT Chan, A Roghanian, RR French, CI Mockridge, AL Tutt, ... The Journal of Immunology 187 (4), 1754-1763, 2011 | 290 | 2011 |
Type II (tositumomab) anti-CD20 monoclonal antibody out performs type I (rituximab-like) reagents in B-cell depletion regardless of complement activation SA Beers, CHT Chan, S James, RR French, KE Attfield, CM Brennan, ... Blood, The Journal of the American Society of Hematology 112 (10), 4170-4177, 2008 | 253 | 2008 |
Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells A Ivanov, SA Beers, CA Walshe, J Honeychurch, W Alduaij, KL Cox, ... The Journal of clinical investigation 119 (8), 2143-2159, 2009 | 239 | 2009 |
Conformation of the human immunoglobulin G2 hinge imparts superagonistic properties to immunostimulatory anticancer antibodies AL White, HTC Chan, RR French, J Willoughby, CI Mockridge, ... Cancer cell 27 (1), 138-148, 2015 | 235 | 2015 |
Induction of cytosolic calcium flux by CD20 is dependent upon B Cell antigen receptor signaling CA Walshe, SA Beers, RR French, CHT Chan, PW Johnson, GK Packham, ... Journal of Biological Chemistry 283 (25), 16971-16984, 2008 | 215 | 2008 |
Fc-engineering for modulated effector functions—improving antibodies for cancer treatment R Liu, RJ Oldham, E Teal, SA Beers, MS Cragg Antibodies 9 (4), 64, 2020 | 189 | 2020 |
The antibacterial properties of secreted phospholipases A2: a major physiological role for the group IIA enzyme that depends on the very high pI of the enzyme to allow … SA Beers, AG Buckland, RS Koduri, W Cho, MH Gelb, DC Wilton Journal of Biological Chemistry 277 (3), 1788-1793, 2002 | 165 | 2002 |
Antagonistic human FcγRIIB (CD32B) antibodies have anti-tumor activity and overcome resistance to antibody therapy in vivo A Roghanian, I Teige, L Mårtensson, KL Cox, M Kovacek, A Ljungars, ... Cancer cell 27 (4), 473-488, 2015 | 157 | 2015 |
Antibodies to costimulatory receptor 4-1BB enhance anti-tumor immunity via T regulatory cell depletion and promotion of CD8 T cell effector function SL Buchan, L Dou, M Remer, SG Booth, SN Dunn, C Lai, M Semmrich, ... Immunity 49 (5), 958-970. e7, 2018 | 142 | 2018 |
Influence of immunoglobulin isotype on therapeutic antibody function SA Beers, MJ Glennie, AL White Blood, The Journal of the American Society of Hematology 127 (9), 1097-1101, 2016 | 140 | 2016 |
Antigenic modulation limits the effector cell mechanisms employed by type I anti-CD20 monoclonal antibodies TRW Tipton, A Roghanian, RJ Oldham, MJ Carter, KL Cox, CI Mockridge, ... Blood, The Journal of the American Society of Hematology 125 (12), 1901-1909, 2015 | 92 | 2015 |
Inhibitory FcγRIIb (CD32b) becomes activated by therapeutic mAb in both cis and trans and drives internalization according to antibody specificity AT Vaughan, C Iriyama, SA Beers, CHT Chan, SH Lim, EL Williams, ... Blood, The Journal of the American Society of Hematology 123 (5), 669-677, 2014 | 87 | 2014 |
STING activation reverses lymphoma-mediated resistance to antibody immunotherapy LN Dahal, L Dou, K Hussain, R Liu, A Earley, KL Cox, S Murinello, I Tracy, ... Cancer research 77 (13), 3619-3631, 2017 | 83 | 2017 |