Seuraa
Luke W. Koblan
Luke W. Koblan
WIBR
Vahvistettu sähköpostiosoite verkkotunnuksessa wi.mit.edu
Nimike
Viittaukset
Viittaukset
Vuosi
Search-and-replace genome editing without double-strand breaks or donor DNA
AV Anzalone, PB Randolph, JR Davis, AA Sousa, LW Koblan, JM Levy, ...
Nature 576 (7785), 149-157, 2019
41602019
Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors
AV Anzalone, LW Koblan, DR Liu
Nature biotechnology 38 (7), 824-844, 2020
19312020
Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction
LW Koblan, JL Doman, C Wilson, JM Levy, T Tay, GA Newby, JP Maianti, ...
Nature biotechnology 36 (9), 843-846, 2018
9272018
Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C: G-to-T: A base editors with higher efficiency and product purity
AC Komor, KT Zhao, MS Packer, NM Gaudelli, AL Waterbury, LW Koblan, ...
Science advances 3 (8), eaao4774, 2017
8742017
Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity
MF Richter, KT Zhao, E Eton, A Lapinaite, GA Newby, BW Thuronyi, ...
Nature biotechnology 38 (7), 883-891, 2020
8142020
Cytosine and adenine base editing of the brain, liver, retina, heart and skeletal muscle of mice via adeno-associated viruses
JM Levy, WH Yeh, N Pendse, JR Davis, E Hennessey, R Butcher, ...
Nature biomedical engineering 4 (1), 97-110, 2020
4202020
Continuous evolution of base editors with expanded target compatibility and improved activity
BW Thuronyi, LW Koblan, JM Levy, WH Yeh, C Zheng, GA Newby, ...
Nature biotechnology 37 (9), 1070-1079, 2019
4152019
Programmable deletion, replacement, integration and inversion of large DNA sequences with twin prime editing
AV Anzalone, XD Gao, CJ Podracky, AT Nelson, LW Koblan, A Raguram, ...
Nature biotechnology 40 (5), 731-740, 2022
4122022
In vivo base editing rescues Hutchinson–Gilford progeria syndrome in mice
LW Koblan, MR Erdos, C Wilson, WA Cabral, JM Levy, ZM Xiong, ...
Nature 589 (7843), 608-614, 2021
4052021
Base editing of haematopoietic stem cells rescues sickle cell disease in mice
GA Newby, JS Yen, KJ Woodard, T Mayuranathan, CR Lazzarotto, Y Li, ...
Nature 595 (7866), 295-302, 2021
3172021
Massively parallel assessment of human variants with base editor screens
RE Hanna, M Hegde, CR Fagre, PC DeWeirdt, AK Sangree, Z Szegletes, ...
Cell 184 (4), 1064-1080. e20, 2021
2632021
Efficient C• G-to-G• C base editors developed using CRISPRi screens, target-library analysis, and machine learning
LW Koblan, M Arbab, MW Shen, JA Hussmann, AV Anzalone, JL Doman, ...
Nature biotechnology 39 (11), 1414-1425, 2021
1882021
Adenine base editing in an adult mouse model of tyrosinaemia
CQ Song, T Jiang, M Richter, LH Rhym, LW Koblan, MP Zafra, ...
Nature biomedical engineering 4 (1), 125-130, 2020
1872020
A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity
DA Bachovchin, LW Koblan, W Wu, Y Liu, Y Li, P Zhao, I Woznica, Y Shu, ...
Nature chemical biology 10 (8), 656-663, 2014
892014
CRISPR technologies for genome, epigenome and transcriptome editing
L Villiger, J Joung, L Koblan, J Weissman, OO Abudayyeh, ...
Nature Reviews Molecular Cell Biology 25 (6), 464-487, 2024
642024
Deciphering cell states and genealogies of human haematopoiesis
C Weng, F Yu, D Yang, M Poeschla, LA Liggett, MG Jones, X Qiu, ...
Nature 627 (8003), 389-398, 2024
582024
High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases
JL Bessen, LK Afeyan, V Dančík, LW Koblan, DB Thompson, C Leichner, ...
Nature Communications 10 (1), 1937, 2019
422019
Incorporation of unnatural amino acids into proteins using base editing
JP Maianti, DR Liu, LW Koblan
US Patent 11,542,509, 2023
362023
Base editors and uses thereof
DR Liu, LW Koblan, CG Wilson, JL Doman
US Patent 12,157,760, 2024
272024
Cytosine to guanine base editor
DR Liu, LW Koblan
US Patent 11,542,496, 2023
252023
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Artikkelit 1–20