Death signal-induced localization of p53 protein to mitochondria: a potential role in apoptotic signaling ND Marchenko, A Zaika, UM Moll Journal of Biological Chemistry 275 (21), 16202-16212, 2000 | 1238 | 2000 |
A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking JM Stommel, ND Marchenko, GS Jimenez, UM Moll, TJ Hope, GM Wahl The EMBO journal 18 (6), 1660-1672, 1999 | 999 | 1999 |
p53 opens the mitochondrial permeability transition pore to trigger necrosis AV Vaseva, ND Marchenko, K Ji, SE Tsirka, S Holzmann, UM Moll Cell 149 (7), 1536-1548, 2012 | 840 | 2012 |
SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis D Li, ND Marchenko, UM Moll Cell Death & Differentiation 18 (12), 1904-1913, 2011 | 382 | 2011 |
Monoubiquitylation promotes mitochondrial p53 translocation ND Marchenko, S Wolff, S Erster, K Becker, UM Moll The EMBO journal 26 (4), 923-934, 2007 | 375 | 2007 |
Functional inactivation of endogenous MDM2 and CHIP by HSP90 causes aberrant stabilization of mutant p53 in human cancer cells D Li, ND Marchenko, R Schulz, V Fischer, T Velasco-Hernandez, F Talos, ... Molecular Cancer Research 9 (5), 577-588, 2011 | 339 | 2011 |
p53 and Nur77/TR3–transcription factors that directly target mitochondria for cell death induction UM Moll, N Marchenko, XK Zhang Oncogene 25 (34), 4725-4743, 2006 | 325 | 2006 |
WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization Y Tomita, N Marchenko, S Erster, A Nemajerova, A Dehner, C Klein, ... Journal of Biological Chemistry 281 (13), 8600-8606, 2006 | 309 | 2006 |
Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis W Hanel, N Marchenko, S Xu, S Xiaofeng Yu, W Weng, U Moll Cell Death & Differentiation 20 (7), 898-909, 2013 | 299 | 2013 |
Overexpression of the wild type p73 gene in breast cancer tissues and cell lines AI Zaika, S Kovalev, ND Marchenko, UM Moll Cancer Research 59 (13), 3257-3263, 1999 | 289 | 1999 |
Hypoxia death stimulus induces translocation of p53 protein to mitochondria: detection by immunofluorescence on whole cells C Sansome, A Zaika, ND Marchenko, UM Moll FEBS letters 488 (3), 110-115, 2001 | 257 | 2001 |
A quantitative analysis of rate-limiting steps in the metastatic cascade using human-specific real-time polymerase chain reaction A Zijlstra, R Mellor, G Panzarella, RT Aimes, JD Hooper, ND Marchenko, ... Cancer research 62 (23), 7083-7092, 2002 | 251 | 2002 |
Expression level, allelic origin, and mutation analysis of the p73 gene in neuroblastoma tumors and cell lines S Kovalev, N Marchenko, S Swendeman, M LaQuaglia, UM Moll Cell Growth and Differentiation-Publication American Association for Cancer …, 1998 | 198 | 1998 |
Promoter characterization of the novel human matrix metalloproteinase-26 gene: regulation by the T-cell factor-4 implies specific expression of the gene in cancer cells of … GN Marchenko, ND Marchenko, J Leng, AY Strongin Biochemical Journal 363 (2), 253-262, 2002 | 136 | 2002 |
Stress-mediated nuclear stabilization of p53 is regulated by ubiquitination and importin-α3 binding ND Marchenko, W Hanel, D Li, K Becker, N Reich, UM Moll Cell Death & Differentiation 17 (2), 255-267, 2010 | 135 | 2010 |
Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression R Schulz, ND Marchenko, L Holembowski, G Fingerle-Rowson, M Pesic, ... Journal of Experimental Medicine 209 (2), 275-289, 2012 | 127 | 2012 |
β-Catenin regulates the gene of MMP-26, a novel matrix metalloproteinase expressed both in carcinomas and normal epithelial cells ND Marchenko, GN Marchenko, RN Weinreb, JD Lindsey, ... The international journal of biochemistry & cell biology 36 (5), 942-956, 2004 | 126 | 2004 |
p53 loss-of-heterozygosity is a necessary prerequisite for mutant p53 stabilization and gain-of-function in vivo EM Alexandrova, SA Mirza, S Xu, R Schulz-Heddergott, ND Marchenko, ... Cell death & disease 8 (3), e2661-e2661, 2017 | 123 | 2017 |
HER2/ErbB2 activates HSF1 and thereby controls HSP90 clients including MIF in HER2-overexpressing breast cancer R Schulz, F Streller, AH Scheel, J Rueschoff, MC Reinert, M Dobbelstein, ... Cell death & disease 5 (1), e980-e980, 2014 | 105 | 2014 |
Mitochondrial death functions of p53 ND Marchenko, UM Moll Molecular & cellular oncology 1 (2), e955995, 2014 | 103 | 2014 |