| Baicalein alleviates hyperuricemia by promoting uric acid excretion and inhibiting xanthine oxidase Y Chen, Z Zhao, Y Li, Y Yang, L Li, Y Jiang, C Lin, Y Cao, P Zhou, Y Tian, ... Phytomedicine 80, 153374, 2021 | 91 | 2021 |
| Dynamic PIP2 interactions with voltage sensor elements contribute to KCNQ2 channel gating Q Zhang, P Zhou, Z Chen, M Li, H Jiang, Z Gao, H Yang Proceedings of the National Academy of Sciences 110 (50), 20093-20098, 2013 | 83 | 2013 |
| Distinct molecular mechanisms underlying potassium efflux for NLRP3 inflammasome activation Z Xu, Z Chen, X Wu, L Zhang, Y Cao, P Zhou Frontiers in immunology 11, 609441, 2020 | 81 | 2020 |
| Activation of human ether-a-go-go related gene (hERG) potassium channels by small molecules P Zhou, J Babcock, L Liu, M Li, Z Gao Acta Pharmacologica Sinica 32 (6), 781-788, 2011 | 74 | 2011 |
| Apigenin ameliorates hyperuricemic nephropathy by inhibiting URAT1 and GLUT9 and relieving renal fibrosis via the Wnt/β-catenin pathway Y Li, Z Zhao, J Luo, Y Jiang, L Li, Y Chen, L Zhang, Q Huang, Y Cao, ... Phytomedicine 87, 153585, 2021 | 67 | 2021 |
| Phosphatidylinositol 4, 5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels P Zhou, H Yu, M Gu, F Nan, Z Gao, M Li Proceedings of the National Academy of Sciences 110 (21), 8726-8731, 2013 | 51 | 2013 |
| Discovery of novel small molecule TLR4 inhibitors as potent anti-inflammatory agents Y Xu, S Chen, Y Cao, P Zhou, Z Chen, K Cheng European Journal of Medicinal Chemistry 154, 253-266, 2018 | 43 | 2018 |
| DCPIB, an inhibitor of volume-regulated anion channels, distinctly modulates K2P channels J Lv, Y Liang, S Zhang, Q Lan, Z Xu, X Wu, L Kang, J Ren, Y Cao, T Wu, ... ACS chemical neuroscience 10 (6), 2786-2793, 2019 | 35 | 2019 |
| CDER167, a dual inhibitor of URAT1 and GLUT9, is a novel and potent uricosuric candidate for the treatment of hyperuricemia Z Zhao, Y Jiang, Y Chen, T Wu, Q Lan, Y Li, L Li, Y Yang, C Lin, Y Cao, ... Acta Pharmacologica Sinica 43 (1), 121-132, 2022 | 34 | 2022 |
| LRRC8 N termini influence pore properties and gating of volume-regulated anion channels (VRACs) P Zhou, MM Polovitskaya, TJ Jentsch Journal of Biological Chemistry 293 (35), 13440-13451, 2018 | 32 | 2018 |
| Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator which rescues LQTs mutants Y Zheng, X Zhu, P Zhou, X Lan, H Xu, M Li, Z Gao PloS one 7 (12), e51820, 2012 | 31 | 2012 |
| Discovery of novel verinurad analogs as dual inhibitors of URAT1 and GLUT9 with improved Druggability for the treatment of hyperuricemia Z Zhao, J Liu, P Kuang, J Luo, G Surineni, X Cen, T Wu, Y Cao, P Zhou, ... European journal of medicinal chemistry 229, 114092, 2022 | 25 | 2022 |
| HCN channel as therapeutic targets for heart failure and pain Y Cao, J Pang, P Zhou Current Topics in Medicinal Chemistry 16 (16), 1855-1861, 2016 | 25 | 2016 |
| Discovery of a retigabine derivative that inhibits KCNQ2 potassium channels H Hu, P Zhou, F Chen, M Li, F Nan, Z Gao Acta Pharmacologica Sinica 34 (10), 1359-1366, 2013 | 24 | 2013 |
| Structural insights into the atomistic mechanisms of uric acid recognition and translocation of human urate anion transporter 1 Z Zhao, Y Jiang, L Li, Y Chen, Y Li, Q Lan, T Wu, C Lin, Y Cao, ... ACS omega 5 (51), 33421-33432, 2020 | 21 | 2020 |
| Apigenin, a novel candidate involving herb-drug interaction (HDI), interacts with organic anion transporter 1 (OAT1) T Wu, H Li, J Chen, Y Cao, W Fu, P Zhou, J Pang Pharmacological Reports 69 (6), 1254-1262, 2017 | 21 | 2017 |
| Inhibition of hyperpolarization‐activated cyclic nucleotide‐gated channels by β‐blocker carvedilol Y Cao, S Chen, Y Liang, T Wu, J Pang, S Liu, P Zhou British Journal of Pharmacology 175 (20), 3963-3975, 2018 | 20 | 2018 |
| ML365 inhibits TWIK2 channel to block ATP-induced NLRP3 inflammasome X Wu, J Lv, S Zhang, X Yi, Z Xu, Y Zhi, B Zhao, J Pang, KKL Yung, S Liu, ... Acta Pharmacologica Sinica 43 (4), 992-1000, 2022 | 18 | 2022 |
| Characterizations of the urate transporter, GLUT9, and its potent inhibitors by patch-clamp technique Y Chen, Z Zhao, Y Li, L Li, Y Jiang, Y Cao, P Zhou, T Wu, J Pang SLAS DISCOVERY: Advancing the Science of Drug Discovery 26 (3), 450-459, 2021 | 18 | 2021 |
| P-retigabine: an N-propargyled retigabine with improved brain distribution and enhanced antiepileptic activity P Zhou, Y Zhang, H Xu, F Chen, X Chen, X Li, X Pi, L Wang, L Zhan, ... Molecular pharmacology 87 (1), 31-38, 2015 | 18 | 2015 |