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Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease KM De Lange, L Moutsianas, JC Lee, CA Lamb, Y Luo, NA Kennedy, ... Nature genetics 49 (2), 256-261, 2017 | 1423 | 2017 |
Multi-ancestry genome-wide association analyses identify novel genetic mechanisms in rheumatoid arthritis K Ishigaki, S Sakaue, C Terao, Y Luo, K Sonehara, K Yamaguchi, ... Nature genetics 54 (11), 1640-1651, 2022 | 216 | 2022 |
Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7 Y Luo, KM De Lange, L Jostins, L Moutsianas, J Randall, NA Kennedy, ... Nature genetics 49 (2), 186-192, 2017 | 212 | 2017 |
Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone YG Tong, WF Shi, D Liu, J Qian, L Liang, XC Bo, J Liu, HG Ren, H Fan, ... Nature 524 (7563), 93-96, 2015 | 212 | 2015 |
Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration J Curtis, Y Luo, HL Zenner, D Cuchet-Lourenço, C Wu, K Lo, M Maes, ... Nature genetics 47 (5), 523-527, 2015 | 203 | 2015 |
HLA class II sequence variants influence tuberculosis risk in populations of European ancestry G Sveinbjornsson, DF Gudbjartsson, BV Halldorsson, KG Kristinsson, ... Nature genetics 48 (3), 318-322, 2016 | 154 | 2016 |
Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes HJ Westra, M Martínez-Bonet, S Onengut-Gumuscu, A Lee, Y Luo, ... Nature genetics 50 (10), 1366-1374, 2018 | 145 | 2018 |
Single-cell eQTL models reveal dynamic T cell state dependence of disease loci A Nathan, S Asgari, K Ishigaki, C Valencia, T Amariuta, Y Luo, JI Beynor, ... Nature 606 (7912), 120-128, 2022 | 132 | 2022 |
A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response Y Luo, M Kanai, W Choi, X Li, S Sakaue, K Yamamoto, K Ogawa, ... Nature Genetics 53 (10), 1504-1516, 2021 | 124 | 2021 |
Population-specific causal disease effect sizes in functionally important regions impacted by selection H Shi, S Gazal, M Kanai, EM Koch, AP Schoech, KM Siewert, SS Kim, ... Nature communications 12 (1), 1098, 2021 | 122 | 2021 |
Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis Interleukin 1 Genetics Consortium The Lancet Diabetes & Endocrinology 3 (4), 243-253, 2015 | 122 | 2015 |
Allele-specific expression changes dynamically during T cell activation in HLA and other autoimmune loci M Gutierrez-Arcelus, Y Baglaenko, J Arora, S Hannes, Y Luo, T Amariuta, ... Nature genetics 52 (3), 247-253, 2020 | 109 | 2020 |
Intra-host dynamics of Ebola virus during 2014 M Ni, C Chen, J Qian, HX Xiao, WF Shi, Y Luo, HY Wang, Z Li, J Wu, ... Nature microbiology 1 (11), 1-9, 2016 | 88 | 2016 |
HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors K Ishigaki, KA Lagattuta, Y Luo, EA James, JH Buckner, S Raychaudhuri Nature genetics 54 (4), 393-402, 2022 | 77 | 2022 |
Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment and disease A Nathan, JI Beynor, Y Baglaenko, S Suliman, K Ishigaki, S Asgari, ... Nature immunology 22 (6), 781-793, 2021 | 75 | 2021 |
Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations Y Luo, X Li, X Wang, S Gazal, JM Mercader, Me Research Team, ... Human molecular genetics 30 (16), 1521-1534, 2021 | 71 | 2021 |
A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis MA Rivas, D Graham, P Sulem, C Stevens, AN Desch, P Goyette, ... Nature communications 7 (1), 12342, 2016 | 70 | 2016 |
Early progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians Y Luo, S Suliman, S Asgari, T Amariuta, Y Baglaenko, M Martínez-Bonet, ... Nature Communications 10 (1), 3765, 2019 | 66 | 2019 |
A positively selected FBN1 missense variant reduces height in Peruvian individuals S Asgari, Y Luo, A Akbari, GM Belbin, X Li, DN Harris, M Selig, E Bartell, ... Nature 582 (7811), 234-239, 2020 | 62 | 2020 |