A map of human genome variation from population scale sequencing 1000 Genomes Project Consortium Nature 467 (7319), 1061, 2010 | 8909 | 2010 |
An integrated map of genetic variation from 1,092 human genomes 1000 Genomes Project Consortium Nature 491 (7422), 56, 2012 | 8628 | 2012 |
Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease L Jostins, S Ripke, RK Weersma, RH Duerr, DP McGovern, KY Hui, ... Nature 491 (7422), 119-124, 2012 | 5599* | 2012 |
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci A Franke, DPB McGovern, JC Barrett, K Wang, GL Radford-Smith, ... Nature genetics 42 (12), 1118-1125, 2010 | 3204 | 2010 |
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations JZ Liu, S Van Sommeren, H Huang, SC Ng, R Alberts, A Takahashi, ... Nature genetics 47 (9), 979-986, 2015 | 2725 | 2015 |
A systematic survey of loss-of-function variants in human protein-coding genes DG MacArthur, S Balasubramanian, A Frankish, N Huang, J Morris, ... Science 335 (6070), 823-828, 2012 | 1426 | 2012 |
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease KM De Lange, L Moutsianas, JC Lee, CA Lamb, Y Luo, NA Kennedy, ... Nature genetics 49 (2), 256-261, 2017 | 1423 | 2017 |
Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study I Cleynen, G Boucher, L Jostins, LP Schumm, S Zeissig, T Ahmad, ... The Lancet 387 (10014), 156-167, 2016 | 888 | 2016 |
Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression BP Fairfax, P Humburg, S Makino, V Naranbhai, D Wong, E Lau, L Jostins, ... Science 343 (6175), 1246949, 2014 | 855 | 2014 |
Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci D Ellinghaus, L Jostins, SL Spain, A Cortes, J Bethune, B Han, YR Park, ... Nature genetics 48 (5), 510-518, 2016 | 795 | 2016 |
Fine-mapping inflammatory bowel disease loci to single-variant resolution H Huang, M Fang, L Jostins, M Umićević Mirkov, G Boucher, ... Nature 547 (7662), 173-178, 2017 | 668 | 2017 |
Integrating sequence and array data to create an improved 1000 Genomes Project haplotype reference panel O Delaneau, J Marchini Nature communications 5 (1), 3934, 2014 | 473 | 2014 |
Class II HLA interactions modulate genetic risk for multiple sclerosis Nature genetics 47 (10), 1107-1113, 2015 | 443 | 2015 |
Integrative annotation of variants from 1092 humans: application to cancer genomics E Khurana, Y Fu, V Colonna, XJ Mu, HM Kang, T Lappalainen, A Sboner, ... Science 342 (6154), 1235587, 2013 | 419 | 2013 |
Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease SG Ji, BD Juran, S Mucha, T Folseraas, L Jostins, E Melum, N Kumasaka, ... Nature genetics 49 (2), 269-273, 2017 | 369 | 2017 |
Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis JZ Liu, MA Almarri, DJ Gaffney, GF Mells, L Jostins, HJ Cordell, SJ Ducker, ... Nature genetics 44 (10), 1137-1141, 2012 | 320 | 2012 |
Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease JC Lee, D Biasci, R Roberts, RB Gearry, JC Mansfield, T Ahmad, ... Nature genetics 49 (2), 262-268, 2017 | 284 | 2017 |
Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity CA Dendrou, A Cortes, L Shipman, HG Evans, KE Attfield, L Jostins, ... Science translational medicine 8 (363), 363ra149-363ra149, 2016 | 262 | 2016 |
Negligible impact of rare autoimmune-locus coding-region variants on missing heritability KA Hunt, V Mistry, NA Bockett, T Ahmad, M Ban, JN Barker, JC Barrett, ... Nature 498 (7453), 232-235, 2013 | 244 | 2013 |
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity DJ Ahern, Z Ai, M Ainsworth, C Allan, A Allcock, B Angus, MA Ansari, ... Cell 185 (5), 916-938. e58, 2022 | 242 | 2022 |