| Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria SA Charman, S Arbe-Barnes, IC Bathurst, R Brun, M Campbell, ... Proceedings of the National Academy of Sciences 108 (11), 4400-4405, 2011 | 464 | 2011 |
| Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors … JM Coteron, M Marco, J Esquivias, X Deng, KL White, J White, M Koltun, ... Journal of medicinal chemistry 54 (15), 5540-5561, 2011 | 337 | 2011 |
| Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in mice R Gujjar, A Marwaha, F El Mazouni, J White, KL White, S Creason, ... Journal of medicinal chemistry 52 (7), 1864-1872, 2009 | 299 | 2009 |
| (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium MB Jiménez-Díaz, D Ebert, Y Salinas, A Pradhan, AM Lehane, ... Proceedings of the National Academy of Sciences 111 (50), E5455-E5462, 2014 | 291 | 2014 |
| Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase T Paquet, C Le Manach, DG Cabrera, Y Younis, PP Henrich, TS Abraham, ... Science translational medicine 9 (387), eaad9735, 2017 | 273 | 2017 |
| Chronic stress accelerates pancreatic cancer growth and invasion: a critical role for beta-adrenergic signaling in the pancreatic microenvironment C Kim-Fuchs, CP Le, MA Pimentel, D Shackleford, D Ferrari, E Angst, ... Brain, behavior, and immunity 40, 40-47, 2014 | 273 | 2014 |
| Quinolone-3-diarylethers: a new class of antimalarial drug A Nilsen, AN LaCrue, KL White, IP Forquer, RM Cross, J Marfurt, ... Science translational medicine 5 (177), 177ra37-177ra37, 2013 | 256 | 2013 |
| Lead Optimization of Aryl and Aralkyl Amine-Based Triazolopyrimidine Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase with Antimalarial … R Gujjar, F El Mazouni, KL White, J White, S Creason, DM Shackleford, ... Journal of medicinal chemistry 54 (11), 3935-3949, 2011 | 196 | 2011 |
| The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson’s disease LW Hung, VL Villemagne, L Cheng, NA Sherratt, S Ayton, AR White, ... Journal of Experimental Medicine 209 (4), 837-854, 2012 | 191 | 2012 |
| Intestinal lymphatic transport of halofantrine occurs after oral administration of a unit-dose lipid-based formulation to fasted dogs SM Khoo, DM Shackleford, CJH Porter, GA Edwards, WN Charman Pharmaceutical research 20, 1460-1465, 2003 | 180 | 2003 |
| Discovery of 7-Hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a Tubulin Polymerization Inhibitor with Potent Antiproliferative … BL Flynn, GS Gill, DW Grobelny, JH Chaplin, D Paul, AF Leske, ... Journal of medicinal chemistry 54 (17), 6014-6027, 2011 | 171 | 2011 |
| 3, 5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential Y Younis, F Douelle, TS Feng, DG Cabrera, CL Manach, AT Nchinda, ... Journal of medicinal chemistry 55 (7), 3479-3487, 2012 | 163 | 2012 |
| Preoperative β-blockade with propranolol reduces biomarkers of metastasis in breast cancer: a phase II randomized trial JG Hiller, SW Cole, EM Crone, DJ Byrne, DM Shackleford, JMB Pang, ... Clinical cancer research 26 (8), 1803-1811, 2020 | 159 | 2020 |
| Contribution of lymphatically transported testosterone undecanoate to the systemic exposure of testosterone after oral administration of two andriol formulations in conscious … DM Shackleford, WAF Faassen, N Houwing, H Lass, GA Edwards, ... The Journal of pharmacology and experimental therapeutics 306 (3), 925-933, 2003 | 145 | 2003 |
| Antimalarial Pyrido[1,2-a]benzimidazoles AJ Ndakala, RK Gessner, PW Gitari, N October, KL White, A Hudson, ... Journal of medicinal chemistry 54 (13), 4581-4589, 2011 | 137 | 2011 |
| Antimalarial Activity of Pyrroloiminoquinones from the Australian Marine Sponge Zyzzya sp. RA Davis, MS Buchanan, S Duffy, VM Avery, SA Charman, WN Charman, ... Journal of medicinal chemistry 55 (12), 5851-5858, 2012 | 106 | 2012 |
| The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson’s disease DI Finkelstein, JL Billings, PA Adlard, S Ayton, A Sedjahtera, CL Masters, ... Acta neuropathologica communications 5, 1-16, 2017 | 99 | 2017 |
| A triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with improved drug-like properties for treatment and prevention of malaria MA Phillips, KL White, S Kokkonda, X Deng, J White, F El Mazouni, ... ACS infectious diseases 2 (12), 945-957, 2016 | 91 | 2016 |
| Antitrypanosomal activity of fexinidazole metabolites, potential new drug candidates for Chagas disease MT Bahia, AFS Nascimento, AL Mazzeti, LF Marques, KR Gonçalves, ... Antimicrobial agents and chemotherapy 58 (8), 4362-4370, 2014 | 90 | 2014 |
| Synthesis and biological evaluation of polysulfated oligosaccharide glycosides as inhibitors of angiogenesis and tumor growth KD Johnstone, T Karoli, L Liu, K Dredge, E Copeman, CP Li, K Davis, ... Journal of medicinal chemistry 53 (4), 1686-1699, 2010 | 90 | 2010 |
