| The DNA sequence of the human X chromosome MT Ross, DV Grafham, AJ Coffey, S Scherer, K McLay, D Muzny, ... Nature 434 (7031), 325-337, 2005 | 1433 | 2005 |
| Drug screening in human PSC-cardiac organoids identifies pro-proliferative compounds acting via the mevalonate pathway RJ Mills, BL Parker, GA Quaife-Ryan, HK Voges, EJ Needham, A Bornot, ... Cell stem cell 24 (6), 895-907. e6, 2019 | 285 | 2019 |
| The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models ST Durant, L Zheng, Y Wang, K Chen, L Zhang, T Zhang, Z Yang, ... Science advances 4 (6), eaat1719, 2018 | 282 | 2018 |
| A review of biomedical datasets relating to drug discovery: a knowledge graph perspective S Bonner, IP Barrett, C Ye, R Swiers, O Engkvist, A Bender, CT Hoyt, ... Briefings in Bioinformatics 23 (6), bbac404, 2022 | 110 | 2022 |
| Understanding the performance of knowledge graph embeddings in drug discovery S Bonner, IP Barrett, C Ye, R Swiers, O Engkvist, CT Hoyt, WL Hamilton Artificial Intelligence in the Life Sciences 2, 100036, 2022 | 68 | 2022 |
| Orally bioavailable and blood–brain barrier-penetrating ATM inhibitor (AZ32) radiosensitizes intracranial gliomas in mice J Karlin, J Allen, SF Ahmad, G Hughes, V Sheridan, R Odedra, ... Molecular cancer therapeutics 17 (8), 1637-1647, 2018 | 67 | 2018 |
| Understanding cytotoxicity and cytostaticity in a high-throughput screening collection LH Mervin, Q Cao, IP Barrett, MA Firth, D Murray, L McWilliams, ... ACS chemical biology 11 (11), 3007-3023, 2016 | 66 | 2016 |
| Orthologue chemical space and its influence on target prediction LH Mervin, KC Bulusu, L Kalash, AM Afzal, F Svensson, MA Firth, I Barrett, ... Bioinformatics 34 (1), 72-79, 2018 | 45 | 2018 |
| Cell morphological profiling enables high-throughput screening for PROteolysis TArgeting Chimera (PROTAC) phenotypic signature MA Trapotsi, E Mouchet, G Williams, T Monteverde, K Juhani, R Turkki, ... ACS Chemical Biology 17 (7), 1733-1744, 2022 | 44 | 2022 |
| Comparison of chemical structure and cell morphology information for multitask bioactivity predictions MA Trapotsi, LH Mervin, AM Afzal, N Sturm, O Engkvist, IP Barrett, ... Journal of chemical information and modeling 61 (3), 1444-1456, 2021 | 41 | 2021 |
| Implications of topological imbalance for representation learning on biomedical knowledge graphs S Bonner, U Kirik, O Engkvist, J Tang, IP Barrett Briefings in bioinformatics 23 (5), bbac279, 2022 | 31 | 2022 |
| A mathematical model of antibody-dependent cellular cytotoxicity (ADCC) F Hoffman, D Gavaghan, J Osborne, IP Barrett, T You, H Ghadially, ... Journal of Theoretical Biology 436, 39-50, 2018 | 31 | 2018 |
| High-content phenotypic assay for proliferation of human iPSC-derived cardiomyocytes identifies L-type calcium channels as targets LA Woo, S Tkachenko, M Ding, AT Plowright, O Engkvist, H Andersson, ... Journal of molecular and cellular cardiology 127, 204-214, 2019 | 28 | 2019 |
| Discovery of retinoic acid receptor agonists as proliferators of cardiac progenitor cells through a phenotypic screening approach L Drowley, J McPheat, A Nordqvist, S Peel, U Karlsson, S Martinsson, ... Stem cells translational medicine 9 (1), 47-60, 2020 | 23 | 2020 |
| Signaling dynamics regulating crosstalks between T-cell activation and immune checkpoints M Kreileder, I Barrett, C Bendtsen, D Brennan, W Kolch Trends in cell biology 31 (3), 224-235, 2021 | 22 | 2021 |
| Automatic extraction of angiogenesis bioprocess from text X Wang, I McKendrick, I Barrett, I Dix, T French, J Tsujii, S Ananiadou Bioinformatics 27 (19), 2730-2737, 2011 | 20 | 2011 |
| Probabilistic Random Forest improves bioactivity predictions close to the classification threshold by taking into account experimental uncertainty LH Mervin, MA Trapotsi, AM Afzal, IP Barrett, A Bender, O Engkvist Journal of Cheminformatics 13, 1-17, 2021 | 19 | 2021 |
| The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models. Sci Adv. 2018; 4 (6): eaat1719 ST Durant, L Zheng, Y Wang, K Chen, L Zhang, T Zhang, Z Yang, ... Article PubMed PubMed Central CAS, 2022 | 13 | 2022 |
| A knowledge graph-enhanced tensor factorisation model for discovering drug targets C Ye, R Swiers, S Bonner, I Barrett IEEE/ACM Transactions on Computational Biology and Bioinformatics 19 (6 …, 2022 | 12 | 2022 |
| New associations between drug-induced adverse events in animal models and humans reveal novel candidate safety targets KA Giblin, D Basili, AM Afzal, L Rosenbrier-Ribeiro, N Greene, I Barrett, ... Chemical Research in Toxicology 34 (2), 438-451, 2020 | 12 | 2020 |
