| Genetic screens in human cells using the CRISPR-Cas9 system T Wang, JJ Wei, DM Sabatini, ES Lander Science 343 (6166), 80-84, 2014 | 3451 | 2014 |
| Cellpose: a generalist algorithm for cellular segmentation C Stringer, T Wang, M Michaelos, M Pachitariu Nature methods 18 (1), 100-106, 2021 | 2677 | 2021 |
| Identification and characterization of essential genes in the human genome T Wang, K Birsoy, NW Hughes, KM Krupczak, Y Post, JJ Wei, ES Lander, ... Science 350 (6264), 1096-1101, 2015 | 1776 | 2015 |
| A unifying model for mTORC1-mediated regulation of mRNA translation CC Thoreen, L Chantranupong, HR Keys, T Wang, NS Gray, DM Sabatini Nature 485 (7396), 109-113, 2012 | 1660 | 2012 |
| An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis K Birsoy, T Wang, WW Chen, E Freinkman, M Abu-Remaileh, DM Sabatini Cell 162 (3), 540-551, 2015 | 1369 | 2015 |
| Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5′ sites S Schwartz, MR Mumbach, M Jovanovic, T Wang, K Maciag, GG Bushkin, ... Cell reports 8 (1), 284-296, 2014 | 1242 | 2014 |
| Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1 S Wang, ZY Tsun, RL Wolfson, K Shen, GA Wyant, ME Plovanich, ... Science 347 (6218), 188-194, 2015 | 862 | 2015 |
| The CASTOR proteins are arginine sensors for the mTORC1 pathway L Chantranupong, SM Scaria, RA Saxton, MP Gygi, K Shen, GA Wyant, ... Cell 165 (1), 153-164, 2016 | 829 | 2016 |
| A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes SM Sidik, D Huet, SM Ganesan, MH Huynh, T Wang, AS Nasamu, P Thiru, ... Cell 166 (6), 1423-1435. e12, 2016 | 816 | 2016 |
| Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides K Birsoy, R Possemato, FK Lorbeer, EC Bayraktar, P Thiru, B Yucel, ... Nature 508 (7494), 108-112, 2014 | 803 | 2014 |
| Gene essentiality profiling reveals gene networks and synthetic lethal interactions with oncogenic Ras T Wang, H Yu, NW Hughes, B Liu, A Kendirli, K Klein, WW Chen, ... Cell 168 (5), 890-903. e15, 2017 | 713 | 2017 |
| The folliculin tumor suppressor is a GAP for the RagC/D GTPases that signal amino acid levels to mTORC1 ZY Tsun, L Bar-Peled, L Chantranupong, R Zoncu, T Wang, C Kim, ... Molecular cell 52 (4), 495-505, 2013 | 605 | 2013 |
| Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway RA Saxton, KE Knockenhauer, RL Wolfson, L Chantranupong, ME Pacold, ... Science 351 (6268), 53-58, 2016 | 492 | 2016 |
| Absolute quantification of matrix metabolites reveals the dynamics of mitochondrial metabolism WW Chen, E Freinkman, T Wang, K Birsoy, DM Sabatini Cell 166 (5), 1324-1337. e11, 2016 | 468 | 2016 |
| A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors RJ Park, T Wang, D Koundakjian, JF Hultquist, P Lamothe-Molina, ... Nature genetics 49 (2), 193-203, 2017 | 381 | 2017 |
| MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors K Birsoy, T Wang, R Possemato, OH Yilmaz, CE Koch, WW Chen, ... Nature genetics 45 (1), 104-108, 2013 | 278 | 2013 |
| Genome-wide methylation analysis and epigenetic unmasking identify tumor suppressor genes in hepatocellular carcinoma K Revill, T Wang, A Lachenmayer, K Kojima, A Harrington, J Li, Y Hoshida, ... Gastroenterology 145 (6), 1424-1435. e25, 2013 | 262 | 2013 |
| Systematic identification of signaling pathways with potential to confer anticancer drug resistance CA Martz, KA Ottina, KR Singleton, JS Jasper, SE Wardell, ... Science signaling 7 (357), ra121-ra121, 2014 | 233 | 2014 |
| SFXN1 is a mitochondrial serine transporter required for one-carbon metabolism N Kory, GA Wyant, G Prakash, J uit de Bos, F Bottanelli, ME Pacold, ... Science 362 (6416), eaat9528, 2018 | 186 | 2018 |
| A CRISPR screen identifies a pathway required for paraquat-induced cell death CR Reczek, K Birsoy, H Kong, I Martínez-Reyes, T Wang, P Gao, ... Nature chemical biology 13 (12), 1274-1279, 2017 | 181 | 2017 |
David M. SabatiniInstitute of Organic Chemistry and Biochemistry of the CASVahvistettu sähköpostiosoite verkkotunnuksessa uochb.cas.cz